Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$110K - $130K *
Lead the design and governance of enterprise security programs, enhancing vulnerability management and attack surface security. Drive risk reduction initiatives across complex environments while commu...
Yesterday
$90K - $115K *
Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...
1 week ago
Adult Psychiatric Nurse Practitioner
$95K - $115K *
Join a dedicated team providing psychiatric care to adult patients, collaborating closely with psychiatrists to enhance mental health outcomes and support patient well-being in a dynamic behavioral he...
Today
$110K - $130K *
Innovate healthcare delivery by developing AI solutions that enhance operations and resident experiences. Collaborate with teams to automate processes and improve clinical decision-making in senior ca...
4 weeks ago
$78K - $110K *
Optimize your career by analyzing investment data and ensuring accurate financial reporting. Collaborate across teams to enhance accounting practices while managing month-end and annual reports in com...
2 weeks ago
Vice President, Reporting and Data Analytics
$202K - $250K *
Champion data-driven decision-making by leading the development of integrated analytics and reporting strategies. Drive operational efficiency and financial performance through innovative data solutio...
1 week ago
$94K - $164K *
Elevate project outcomes by managing medium to high complexity initiatives, ensuring timely delivery, stakeholder engagement, and adherence to best practices throughout the project lifecycle...
4 days ago
Principal Architect, Healthcare
$165K - $243K *
Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...
2 weeks ago
Sr. Associate, Information Security & AI Governance Analyst
$95K - $115K *
Help us shape the future of information security and AI governance by supporting strategic initiatives, managing cybersecurity policies, and conducting digital forensics to ensure compliance and risk...
4 days ago
Director of Clinical Operations, Strategy, and Innovation
$182K - $247K *
Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...
5 days ago
$78K - $95K *
Join our team as a Data QA Analyst, where you'll ensure data migration quality across client onboarding. You'll standardize processes, validate data integrity, and collaborate with cross-functional te...
1 week ago
$105K - $115K *
Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...
3 weeks ago
Senior / Principal Due Diligence Growth Lead
$125K - $150K *
Lead strategies to drive environmental due diligence growth, manage key client relationships, oversee project execution, and ensure delivery of high-quality results through effective team leadership a...
Reposted 2 weeks ago
Director, AI-Enabled Fraud Prevention & Investigations
$150K - $240K *
Transform fraud detection in healthcare by leading end-to-end investigations, coordinating legal support, and leveraging innovative technology to enhance operational integrity and compliance in our Me...
Reposted today
Research Computing Services Manager
$110K - $130K *
Unlock potential by managing research computing infrastructure, guiding teams, and ensuring efficient operations. Collaborate with a dedicated team to drive innovations in patient care while enjoying...
2 weeks ago
$94K - $129K *
Elevate payroll solutions by collaborating with cross-functional teams to translate business needs into technical requirements, ensuring effective delivery and continuous improvement in payroll proces...
2 weeks ago
$94K - $129K *
Transform payroll processes by collaborating with teams to deliver effective solutions, ensuring alignment with business needs and driving continuous improvement in system functionality and performanc...
2 weeks ago
Senior Compliance Oversight Specialist (RN)
$92K - $110K *
Champion compliance excellence by overseeing audits and monitoring activities. Collaborate with teams to ensure adherence to regulatory standards and drive remediation efforts, enhancing integrity acr...
Yesterday
$75K - $90K *
Elevate financial insights as a Senior Financial Analyst, partnering with leaders to drive strategic planning, budgeting, and reporting. Leverage your analytical skills to enhance operational performa...
1 week ago
Senior Director, Commercial Analytics & Decision Science
$219K - $285K *
Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...
1 week ago
$129K - $177K *
Lead the charge in designing and delivering AI capabilities for a platform, integrating advanced workflows and intelligent analysis while actively contributing to production code and managing a small...
3 weeks ago
Engineer, Software Engineering
$112K - $140K *
Contribute to the development of innovative healthcare solutions by designing and maintaining backend services using Java and Spring Boot, while collaborating with a global team to enhance a scalable...
Yesterday
$215K - $408K *
Transform healthcare delivery by leading medical management and quality initiatives. Collaborate with clinical teams to enhance patient outcomes and drive cost-effective care while ensuring compliance...
Reposted 1 week ago
Sales Account Executive (Healthcare)
$280K - $300K *
Drive new business growth by leveraging innovative automation solutions. Build lasting client relationships and serve as a trusted advisor in the Agentic Process Automation space, while exceeding sale...
2 weeks ago
VP, Sales - Global Client Services
$120K - $140K *
Transform global client relationships by driving revenue growth and strategic account management. Collaborate with C-suite executives to connect workplace culture and employee experience to measurable...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.