Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$74K - $124K *
Elevate compensation strategies by transforming complex data into actionable insights. Collaborate with stakeholders to manage compensation programs, analyze trends, and recommend solutions that ensur...
1 week ago
Transaction Management Director - Healthcare
$175K - $220K *
Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...
1 week ago
$160K - $190K *
Transform ambiguity into action by driving strategic initiatives across functions. Collaborate with executives to architect programs that enhance operational efficiency and deliver measurable business...
Reposted yesterday
$150K - $180K *
Engage with key healthcare clients to drive strategic account management, fostering relationships and delivering tailored solutions across GE HealthCare’s diverse portfolio, while leading cross-functi...
6 days ago
Director - Statistics - Lilly Regenerative Medicines
$193K - $308K *
Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...
2 weeks ago
Senior People Operations Analyst
$85K - $95K *
Unlock potential by managing HR systems and analytics, ensuring data integrity and compliance. Collaborate with cross-functional teams to optimize HR technology and reporting, driving strategic insigh...
Yesterday
Sr Director Analyst- Analytics & AI
$172K - $202K *
Lead the charge in delivering impactful research and insights in analytics and AI. Collaborate with clients to identify needs, drive strategies, and produce high-quality content that shapes market tre...
3 weeks ago
$115K - $117K *
Join a team that's dedicated to enhancing privacy compliance and cybersecurity. Collaborate with stakeholders to assess risks, develop training, and ensure adherence to federal regulations while prote...
3 weeks ago
$101K - $197K *
Empower your career by leading global regulatory strategies for medical devices and diagnostics. Collaborate with cross-functional teams to ensure compliance and drive market access while mentoring ot...
1 month ago
$95K - $115K *
Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...
Reposted 1 week ago
$136K - $187K *
Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...
1 week ago
$125K - $150K *
Elevate client relationships as a strategic leader, driving retention and growth. Collaborate with cross-functional teams to deliver exceptional service and develop high-performing teams focused on cl...
1 month ago
Senior Director of Strategic Planning and Analysis
$185K - $315K *
Join us to shape strategic financial planning and analysis, leveraging AI to enhance forecasting and decision-making. This high-impact role collaborates with executives, driving insights that align wi...
6 days ago
Manager, Product Management - Provider Contracting, Credentialing & Network
$108K - $180K *
Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...
1 week ago
Customer Success Operations Analyst
$120K - $130K *
Drive the transformation of customer data into automated reporting and AI tools, enhancing customer health tracking and executive visibility. Collaborate across teams to streamline workflows and ensur...
3 weeks ago
Director, Strategic Initiatives
$134K - $249K *
Champion high-impact strategic initiatives that drive Provider Data Operations. Lead cross-functional teams, navigate complexities, and ensure measurable outcomes through effective execution and stake...
Today
$115K - $158K *
Join us to shape the future of member experiences in healthcare by leading innovative design projects, collaborating with cross-functional teams, and enhancing service delivery through user-centered d...
1 week ago
$62K - $104K *
Unlock potential by designing and implementing behavior intervention plans. Collaborate with IEP teams and staff to foster skill-building and independence for students with behavioral challenges acros...
Reposted 6 days ago
Territory Director / Client Services
$110K - $130K *
Lead the charge in cultivating strategic client relationships while managing a team to drive retention and growth. Oversee account management initiatives, ensuring alignment with corporate goals and d...
2 days ago
Senior Financial Analyst - Strategic Finance
$109K - $173K *
Elevate your career by partnering with us to enhance financial forecasting and reporting processes. Leverage your analytical skills to improve business intelligence systems and drive key performance i...
Reposted 1 week ago
Principal PBM Data Integration Lead
$148K - $205K *
Take ownership of complex PBM data integrations, ensuring accurate claims and eligibility processing while leading cross-functional teams and managing delivery timelines and risks...
1 week ago
General Physician (AI Evaluation)
$125K - $150K *
Join a team that's enhancing healthcare by reviewing AI-generated clinical content for accuracy and safety. Utilize your medical expertise to identify errors and improve AI systems, ensuring reliable...
4 days ago
Enterprise Account Executive - Healthcare Payors
$105K - $127K *
Champion growth by driving enterprise sales in healthcare payors, leveraging SaaS solutions to enhance client experiences. Build relationships, negotiate contracts, and exceed quotas while collaborati...
2 weeks ago
$95K - $115K *
Join a team that's driving innovation in healthcare solutions by collaborating with sales to design and communicate technical solutions that meet customer needs, ensuring alignment with company capabi...
Yesterday
Senior Manager, Evidence & Insights (RWE & HEOR)
$90K - $110K *
Join a team that's shaping evidence strategies and insights in health economics and outcomes research. Lead client engagements, oversee analytics, and drive impactful decision-making in biopharma and...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.