Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$80K - $95K *
Empower clinical excellence across multiple skilled nursing facilities by providing leadership, mentorship, and operational support. Drive quality outcomes and regulatory compliance while fostering a...
2 weeks ago
Senior Director, Regulatory Business Operations
$148K - $274K *
Partner with us to navigate complex regulatory environments, ensuring compliance and facilitating business expansions. Leverage your expertise to advise leadership and manage licensure processes effec...
Reposted 4 days ago
$110K - $120K *
Elevate pricing strategies by analyzing data, guiding deals, and enhancing profitability. Collaborate across teams to drive smarter pricing decisions and improve seller experiences, ensuring competiti...
1 week ago
$95K - $115K *
Transform healthcare delivery by leveraging your Epic Cadence expertise to design, build, and optimize scheduling workflows. Collaborate with teams to ensure successful project outcomes and enhance pa...
6 days ago
Senior Strategy & Decision Analyst
$120K - $145K *
Help us ensure high-quality decision-making by collaborating with leaders to frame strategies and analyze options, driving impactful decisions that align with organizational goals and values while fos...
6 days ago
Principal Software Security Architect
$150K - $180K *
Join a team that's redefining the future by leveraging cutting-edge AI to develop innovative machine learning solutions that solve complex business challenges, and actively collaborating across multid...
Reposted today
Strategic Account Executive - Healthcare
$133K - $177K *
Join a team that's transforming healthcare by driving strategic account growth and solving complex identity challenges. Collaborate with cross-functional teams to deliver measurable outcomes and enhan...
1 week ago
$101K - $126K *
Drive the development and execution of clinical programs, ensuring effective support, education, and coordination across departments while managing health outcomes and utilization data for continuous...
Reposted 6 days ago
$63K - $129K *
Contribute to system quality by executing test cases, analyzing requirements, and validating functionality to ensure compliance and stability in a fast-paced environment. Collaborate with teams to enh...
Reposted 2 weeks ago
Healthcare Coding Expert (certified professional coder)
$77K - $105K *
Join a dynamic team to analyze healthcare claims data, identify fraud trends, and support the Healthcare Fraud Prevention Partnership. Leverage your expertise to drive strategic outcomes and enhance c...
3 weeks ago
$80K - $95K *
Join a team that's dedicated to innovation in analytical science, leading projects and guiding technical staff while ensuring compliance and driving continuous improvement in a collaborative environme...
2 weeks ago
Clinical Research Site Director
$90K - $110K *
Shape the future of clinical research by leading site operations, ensuring compliance, and fostering patient relationships. Collaborate with teams to drive successful trial outcomes and contribute to...
3 weeks ago
Clinical Applications Specialist, Contrast Media Delivery Solutions
$100K - $150K *
Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...
2 weeks ago
$74K - $85K *
Lead the planning and execution of diverse research projects, ensuring alignment with organizational goals. Collaborate with stakeholders to manage timelines, deliverables, and budgets while fostering...
2 weeks ago
Senior Budget Administrator - Clinical Trials
$100K - $161K *
Advance your career by coordinating clinical trial budgets and coverage analyses. Collaborate with stakeholders to ensure compliance and cost efficiency while mentoring junior staff and enhancing admi...
1 week ago
Lead Technical Implementation Analyst
$120K - $150K *
Transform the delivery landscape by leading cross-functional initiatives, mentoring analysts, and driving strategic solutions across business units and external partners. Engage deeply in project exec...
5 days ago
$75K - $110K *
Unlock advanced analytics capabilities by leading data science initiatives that drive informed decision-making and operational efficiency in a regulated environment. Collaborate with stakeholders to d...
1 week ago
$130K - $160K *
Drive the development of LLM-based agents, ensuring robust production systems, effective evaluation, and seamless integration with company data while maintaining security and operational excellence ac...
4 weeks ago
$111K - $167K *
Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...
6 days ago
Lead Consultant, AI & Analytics
$120K - $145K *
Drive the future of AI & Analytics by leading client relationships, providing strategic guidance, and delivering innovative solutions. Leverage your expertise to enhance service delivery and ensure al...
1 week ago
Senior Business Insights Analyst
$110K - $131K *
Transform complex data into actionable insights, partnering with leaders to enhance strategic decision-making and drive organizational performance through advanced analytics and reporting frameworks...
6 days ago
Life Sciences MedTech Supply Chain, Management Consultant
$70K - $205K *
Shape the future of MedTech by empowering global teams to excel in project delivery, leveraging AI, and transforming supply chain strategies while building exceptional client relationships and guiding...
Reposted 6 days ago
Product Manager, Clinical Programs & Case Management
$86K - $138K *
Unlock innovative healthcare solutions by leading product strategy and lifecycle management for clinical programs. Collaborate across teams to enhance member experiences and drive business value while...
2 weeks ago
Senior Forward Deployed Engineer (FDE)
$170K - $205K *
Join a dynamic team to lead AI agent deployments in healthcare. Leverage your software engineering expertise and client-facing skills to drive technical delivery, influence product development, and en...
2 weeks ago
Manager, Coding Hospital & Physician Services
$80K - $95K *
Elevate your career by managing coding operations, ensuring accuracy and compliance across healthcare settings. Lead educational initiatives for staff, optimize workflows, and drive improvements in co...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.