Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Regional Sales Manager, Healthcare
$80K - $95K *
Transform your career by driving sales growth in a dynamic healthcare market. Leverage your consultative selling skills to build relationships, develop new business, and enhance client engagement in a...
3 weeks ago
Financial & Budget Management Analyst, Senior
$128K - $140K *
Lead the charge in financial management for key NGA programs, analyzing budgets, justifying resource allocations, and ensuring program financial health through expert recommendations and detailed repo...
1 week ago
Business Development Manager-Healthcare & Life Science
$110K - $140K *
Elevate our healthcare growth strategy by managing pipeline generation, leveraging AI tools, and driving marketing initiatives. This role demands autonomy and innovation to shape business operations a...
3 weeks ago
$94K - $157K *
Unlock potential by joining our team as a Data Analyst, where you'll leverage your expertise in data manipulation and visualization to support key Federal clients, driving impactful solutions through...
6 days ago
$79K - $127K *
Empower your career by managing and optimizing critical DB2 databases, ensuring high availability and performance in a dynamic healthcare environment. Collaborate with teams to drive continuous improv...
Reposted today
$94K - $120K *
Empower your career as a strategic HR Operations Manager, leading teams and driving data-informed decisions. Build effective systems, enhance performance, and deliver exceptional outcomes while foster...
Reposted 2 days ago
Ambulatory Client Sales Executive
$100K - $120K *
Serve as the primary contact for clients, driving engagement and service quality while fostering relationships with key stakeholders and leveraging expertise to enhance organizational growth and clien...
Reposted 2 weeks ago
Senior Health and Safety Compliance Specialist
$110K - $130K *
Lead the charge in complex H&S compliance projects while mentoring staff, managing client relationships, and ensuring the highest standards of safety and professionalism in a remote work environment...
Reposted 2 weeks ago
Life Sciences Data Management, Senior (MDM/DGov)
$116K - $229K *
Drive innovation in Life Sciences by leveraging AI and data analytics to transform commercial operations. Collaborate with high-performing teams to deliver impactful solutions that enhance client enga...
1 week ago
$247K - $427K *
Join a dynamic team as you lead medical services, ensuring quality care for millions. Drive innovative programs, provide clinical consultation, and enhance operational strategies within a major health...
2 weeks ago
$80K - $95K *
Manage HR functions by aligning workforce strategies with company goals, enhancing employee engagement, and ensuring compliance. Oversee recruitment, onboarding, and performance management while foste...
2 weeks ago
Manager - Financial Planning & Analysis - Apptio
$66K - $145K *
Join a team that's focused on enhancing IT Financial Management through the design and development of scalable digital solutions. Collaborate with business and technical teams to optimize costs, impro...
Reposted today
Clinical Research Associate II
$90K - $110K *
Unlock potential by overseeing clinical trials, ensuring compliance with protocols and regulations. Collaborate with investigators and coordinators to protect participant rights and verify data integr...
1 week ago
Mid-Level CI Analyst - Reachback
$80K - $95K *
Transform intelligence analysis by leveraging your expertise and analytical skills. Collaborate with a dynamic team to support critical missions, utilizing advanced technology and methodologies to dri...
1 week ago
Lead Analyst – Independent Assessment
$98K - $115K *
Lead independent assessments to evaluate bank practices against regulatory standards, ensuring quality and compliance. Collaborate with stakeholders to enhance risk management frameworks and contribut...
4 days ago
Sr Enterprise HCM Consultant Virtual
$100K - $120K *
Take ownership of driving sales growth by identifying client needs and presenting tailored solutions. Collaborate with stakeholders to enhance market share and build lasting relationships through effe...
4 weeks ago
Senior Director Analyst - IAM & AI
$172K - $202K *
Lead the charge in delivering expert guidance on identity and access management technologies, focusing on architecting solutions and producing actionable research to enhance client performance and sec...
Reposted 2 weeks ago
$88K - $105K *
Unlock your potential by researching and designing innovative engineering solutions. Collaborate across teams to improve product performance while ensuring adherence to safety and quality standards, l...
Reposted 4 weeks ago
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
1 week ago
$90K - $110K *
Empower your career by driving project delivery and managing Agile teams. Utilize AI tools to enhance decision-making, anticipate risks, and ensure timely outcomes. Collaborate with stakeholders to ma...
4 weeks ago
Revenue Analytics Finance Manager
$90K - $167K *
Unlock potential by driving revenue insights and financial modeling, enhancing decision-making across finance and operations. Collaborate with stakeholders to refine processes and improve revenue reco...
5 days ago
$109K - $164K *
Drive advanced digital forensics and incident response initiatives while mentoring a skilled engineering team. Leverage deep technical knowledge to enhance operational capabilities and ensure exceptio...
Reposted 2 weeks ago
$75K - $158K *
Support the evolution of Oracle EPM solutions, enhancing business operations through requirements gathering, configuration, and collaboration to drive improvements for military and civilian agencies...
Reposted 2 weeks ago
Provider Engagement Account Executive
$87K - $157K *
Empower healthcare providers through strategic partnerships and data-driven insights to enhance value-based care initiatives, improve performance, and drive member outcomes by utilizing innovative str...
Reposted 5 days ago
$110K - $130K *
Join a team that's dedicated to creating impactful medical education content for healthcare providers and patients. Collaborate closely with scientific and account teams to deliver high-quality materi...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.