Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Manager - Registered Nurse - Critical Care
$80K - $95K *
Transform patient care by managing nursing resources, ensuring compliance, and leading staff development. Drive efficiency and quality in healthcare delivery while monitoring budgets and resolving car...
4 weeks ago
$96K - $144K *
Lead the charge in delivering exceptional customer service and technical support at assigned medical equipment sites, ensuring compliance with contracts and fostering strong client relationships throu...
3 weeks ago
Senior Analyst- Asset Allocation, Wealth Management Advice & Solutions
$110K - $130K *
Contribute to the development of investment strategies and portfolio frameworks by leveraging quantitative analysis, capital market insights, and risk-aware planning across diverse investment programs...
Reposted 6 days ago
Director, Strategy and Operations
$150K - $180K *
Drive strategic planning and operational excellence for a dynamic Marketing & Communications team. Own budgeting, resource management, and cross-functional partnerships while leading initiatives that...
6 days ago
$80K - $95K *
Engineer innovative IT solutions by managing system configurations, evaluating current technologies, and planning upgrades to enhance performance and scalability. Collaborate with teams to ensure syst...
4 weeks ago
Sr. Government Healthcare Actuarial Consultant
$93K - $187K *
Contribute to impactful client engagements by managing service delivery, conducting complex analyses, and guiding junior staff in a dynamic healthcare consulting environment that embraces technology a...
2 weeks ago
Sr. Government Healthcare Actuarial Consultant
$93K - $187K *
Unlock potential by leading client engagements in Government Healthcare Consulting, managing strategy and financial evaluations while leveraging technology. Collaborate with teams to deliver impactful...
3 weeks ago
Director, CAHPS and HOS Strategy and Execution
$130K - $195K *
Innovate member experience strategies by translating enterprise goals into actionable plans. Drive performance improvements in CAHPS and HOS programs through provider engagement and data analysis, ens...
2 weeks ago
$80K - $95K *
Join a team that's dedicated to optimizing hospital technology systems, ensuring reliable operations and support for clinical and business functions while leading troubleshooting efforts and driving c...
4 days ago
Clinical Delivery Leader, CMU Outcomes
$111K - $167K *
Transform your career by leading clinical strategies and implementations, ensuring successful adoption of digital solutions while collaborating with diverse stakeholders to enhance patient safety and...
4 days ago
Dental Policy & Quality Manager
$93K - $132K *
Lead the charge in developing and maintaining dental coverage policies, ensuring clinical integrity and compliance. Collaborate across teams to enhance program infrastructure and support regulatory au...
4 weeks ago
$80K - $95K *
Join a team that's dedicated to matching healthcare providers with facilities, utilizing creative sourcing strategies and consultative skills to meet client needs while achieving personal productivity...
1 week ago
$136K - $187K *
Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...
1 week ago
$80K - $95K *
Shape the future of neurodiverse care by leading clinical services and programming for youth with developmental differences, ensuring high standards and collaborative practices across inpatient and re...
6 days ago
$68K - $105K *
Unlock potential by configuring and supporting Epic Orders applications. Engage in business analysis, system design, and user support to enhance workflows and resolve issues, while managing projects a...
4 weeks ago
Business and Data Analyst [U.S. Citizenship Required, Public Trust Suitability]
$90K *
Shape the future of business analysis by connecting program needs with technical solutions. Leverage your Salesforce expertise to enhance workflows, gather requirements, and collaborate with stakehold...
Reposted 2 days ago
Nurse Practitioner, Advanced Practice Provider
$129K - $148K *
Drive exceptional primary care by providing value-based services to Medicare adults. Collaborate with a dedicated care team to enhance patient relationships, ensure holistic health assessments, and le...
3 weeks ago
Business Analyst, Service Logistics
$95K - $115K *
Drive logistics optimization and cost reduction initiatives across global service operations, enhancing efficiency and performance in transportation and network design while collaborating with cross-f...
Yesterday
Customer Success Partner- Healthcare Vertical
$75K - $90K *
Engage with strategic accounts to drive revenue growth through consultative sales and account management. Develop and maintain account plans, coordinate resources, and ensure customer satisfaction whi...
Reposted 5 days ago
$150K - $180K *
Lead the design and implementation of scalable ML systems, bridging business strategy with technical execution. Drive impactful data solutions, mentor teams, and ensure robust model performance to enh...
Today
$145K - $160K *
Pioneer data-driven insights by collaborating with cross-functional teams to enhance business strategies. Leverage advanced analytics and visualization skills to drive operational improvements and sup...
3 weeks ago
$72K - $116K *
Drive quality assurance initiatives by leading data testing strategies, overseeing validation processes, and guiding technical teams in the healthcare domain. Translate complex data risks into actiona...
3 weeks ago
Senior Technical Analyst Technology Solutions
$88K - $105K *
Transform business needs into technical solutions by defining requirements, enhancing quality through testing, and supporting development pipelines. Collaborate with cross-functional teams to drive ef...
1 week ago
Customer Success Manager (Healthcare SAAS)
$90K - $110K *
Engage with healthcare clients to maximize value from innovative software solutions. Collaborate on onboarding, account health, and usage strategies to enhance customer satisfaction, adoption, and ret...
3 weeks ago
$83K - $117K *
Empower business growth by leading experimentation strategies and analytical initiatives. Utilize advanced statistical techniques to analyze complex datasets, influence decision-making, and drive impa...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.