Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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Healthcare Analyst Jobs in Missouri

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$95K - $115K *

Transform enterprise processes by leading cross-functional improvement initiatives, mentoring analysts, and aligning strategies with organizational goals. Leverage Lean and Six Sigma expertise to driv...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Engage in comprehensive pharmaceutical services, promoting safe medication therapy. Oversee the medication use system and collaborate with medical staff to ensure effective treatment and enhance patie...

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K - $125K *

Unlock your potential as a Revenue Compensation Analyst, where you'll design and manage compensation plans, analyze trends, and collaborate with teams to enhance sales efficiency. Bring your analytica...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$97K - $145K *

Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$64K - $96K *

Join a team that's dedicated to providing exceptional home health care. As a Registered Nurse, you'll coordinate patient care, collaborate with healthcare professionals, and ensure quality service whi...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$71K - $99K *

Join a team that's dedicated to enhancing clinical practices through effective IT solutions. This role involves training, system maintenance, and collaboration with healthcare professionals to optimiz...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $130K *

Join a dynamic team as a Senior Consultant, leading municipal financial analyses and strategies. Drive impactful projects for local governments, enhancing service delivery and sustainability while dev...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$122K - $171K *

Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Empower your career by joining a dynamic team focused on enhancing IT operations. Leverage your expertise in Momentum Financials to drive impactful solutions and collaborate with stakeholders in a hig...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Engage with our Critical Care team to enhance patient outcomes through expert care, rounding in the ICU, performing procedures, and responding to rapid calls. Collaborate with physicians and support s...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $125K *

Contribute to acquiring and managing data partnerships, collaborating with product teams to prioritize and improve dataset quality, while leveraging AI to enhance data processes and achieve business o...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $115K *

Build strong client partnerships and drive growth by managing a portfolio of mid-sized employers. Collaborate cross-functionally to enhance engagement, retention, and revenue while delivering data-dri...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$54K - $145K *

Unlock potential by collaborating with cross-functional teams to deliver impactful analysis and requirements for Medicare and Medicaid enrollment solutions within an Agile framework, ensuring seamless...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$74K - $124K *

Lead audit remediation initiatives by coordinating with stakeholders, analyzing findings, and developing strategies to enhance internal controls and audit readiness, ensuring successful outcomes for f...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$63K - $104K *

Join a team that's dedicated to enhancing patient care through expert nutrition assessments and interventions. Collaborate with healthcare professionals to provide individualized nutrition education a...

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by driving technical integration and validation for Ambient AI Scribe initiatives. Collaborate with clinical teams to enhance workflows, troubleshoot issues, and ensure operational re...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Optimize market intelligence within global diagnostics by leading analytical work, synthesizing data, and translating complex insights into actionable recommendations. Collaborate with diverse stakeho...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Transform project outcomes by analyzing performance data, forecasting costs, and ensuring compliance. Collaborate with contractors to identify risks and present actionable insights to leadership, driv...

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$95K - $115K *

Unlock the potential of seamless data exchange by analyzing EDI requirements, developing maps, and supporting integrations. Collaborate with partners to ensure efficient transactions and enhance elect...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $104K *

Transform financial management for Foreign Military Sales by providing essential support and analysis. Collaborate with stakeholders to ensure compliance and accuracy in financial reporting and case m...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$170K - $200K *

Champion operational excellence by leading business unit strategies, enhancing performance management, and driving cross-functional collaboration to achieve enterprise goals and scalable solutions...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$53K - $132K *

Optimize the configuration and implementation of Oracle Health Drug File systems for client projects. Collaborate with cross-functional teams to ensure successful execution and provide technical exper...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $160K *

Accelerate progress at a dynamic tech firm by owning the full sales cycle for mid-market practices. Collaborate with leadership to shape strategy and drive impactful relationships, ensuring success in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Transform global operations by supporting Power Automate workflows, enhancing collaboration with regional teams, and driving continuous improvement in automation processes to optimize efficiency and e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.