Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Budget and Financial Analyst (Remote)
$95K - $110K *
Lead financial management and analysis efforts to support strategic planning and budget execution for DHS initiatives, ensuring alignment with mission priorities and stakeholder requirements while dri...
6 days ago
Senior Analyst Treasury Cash Forecasting & Analysis
$79K - $112K *
Transform cash forecasting processes by leveraging technology and analytics. Collaborate with Treasury leadership to enhance cash flow insights and automate reporting, ensuring accuracy and efficiency...
1 week ago
$140K - $190K *
Join a team that's transforming clinical trials through advanced data science. Drive the development of predictive models and machine learning algorithms to enhance patient enrollment and trial manage...
3 weeks ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
1 week ago
Director, Application Development Engineering
$146K - $269K *
Shape the future of enterprise software by leading multiple engineering teams, driving application development, and implementing best practices. Collaborate cross-functionally to enhance quality and s...
5 days ago
$180K - $235K *
Drive growth by leveraging your consultative sales expertise to engage higher education leaders, aligning their needs with innovative research solutions while managing client relationships and achievi...
2 weeks ago
Manager, Compliance Risk Adjustment
$87K - $157K *
Join a team that's dedicated to managing external audits for Risk Adjustment processes. Oversee audit deliverables, collaborate with stakeholders, and ensure compliance while driving continuous improv...
4 weeks ago
$100K - $120K *
Unlock potential by shaping innovative medical communication strategies for pharmaceutical clients. Collaborate with cross-functional teams to deliver evidence-based solutions, focusing on metabolic a...
4 days ago
$80K - $95K *
Join a dynamic team as you oversee laboratory operations, ensuring quality control and efficient management of departments while supporting patient care through diagnostic services and staff guidance...
1 week ago
$124K - $155K *
Lead the charge in driving brand growth for pharmaceutical clients by providing strategic counsel, fostering strong relationships, and developing innovative multichannel marketing strategies that adap...
4 days ago
$140K - $170K *
Shape the future of healthcare market strategies by analyzing trends, defining growth initiatives, and collaborating cross-functionally to drive innovation in life science and medical services. Lead m...
1 week ago
Regulatory Strategy Consultant
$125K - $150K *
Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...
2 weeks ago
Actuary - Valuation & Reserving
$107K - $199K *
Analyze financial outcomes and oversee actuarial valuations. Collaborate with teams to enhance processes and communicate results effectively. Leverage advanced analytical skills to support healthcare...
Today
$95K - $115K *
Unlock potential by designing and conducting clinical studies that enhance understanding of new therapies, ensuring quality and efficiency in research deliverables while collaborating with cross-funct...
2 days ago
$140K - $155K *
Champion product innovation by managing software initiatives that enhance internal communication and streamline operations. Collaborate with cross-functional teams to deliver impactful solutions and d...
3 weeks ago
Operations Business Analyst IV - Claims adjudication and/or Facets claims adjudication (preferred)
$94K - $164K *
Champion operational excellence by leading business analysis initiatives, driving process improvements, and aligning solutions with strategic goals to enhance efficiency and effectiveness across the o...
2 weeks ago
$71K - $107K *
Transform patient care by guiding families through the continuum, assessing needs, coordinating care, and managing outpatient services. Collaborate with a dedicated team to ensure optimal health outco...
4 days ago
$89K - $109K *
Drive project accounting excellence by leading a team, ensuring accurate billing, and collaborating with project managers. Oversee financial reporting and client relations while mentoring junior staff...
Today
$110K - $130K *
Drive analytics initiatives that connect Paid Media performance to full-funnel outcomes. Collaborate with cross-functional teams to design measurement frameworks, optimize data models, and provide act...
Reposted 2 weeks ago
Business Analyst - AI Response Evaluation Specialist
$80K - $95K *
Analyze and evaluate AI-generated chatbot responses to enhance accuracy and relevance. Collaborate with stakeholders to document requirements and deliver structured assessments that drive improvements...
Reposted 6 days ago
Business Analyst - AI Response Evaluation Specialist
$80K - $95K *
Transform the evaluation of AI systems by analyzing chatbot responses, documenting requirements, and delivering structured assessments to enhance accuracy and effectiveness in business processes...
1 week ago
$96K *
Join a dynamic Finance team as a Financial Analyst, focusing on sales commissions and SaaS metrics. Collaborate across departments to ensure accurate financial reporting and drive insights that suppor...
2 weeks ago
Epic Professional Billing Analyst 2
$70K - $100K *
Join a team that's dedicated to optimizing Epic Resolute Professional Billing. Support daily operations, troubleshoot issues, and enhance workflows while collaborating with analysts and users to ensur...
3 weeks ago
Senior Full-Stack Engineer - Case Strategy
$120K - $145K *
Shape the future of healthcare by owning and optimizing AI systems. Design and deliver scalable ML solutions that transform operations, enhance decision-making, and create real-world impact across cri...
Reposted 3 weeks ago
Business Development Manager - Acute
$95K - $115K *
Grow your career by driving revenue growth in the acute care market through new customer acquisition and account expansion. Manage the full sales lifecycle while collaborating with internal teams to d...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.