Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$68K - $105K *

Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $188K *

Champion adolescent health initiatives by providing strategic guidance and support to federal agencies, enhancing youth engagement, and implementing evidence-based programs to improve outcomes for ado...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$134K - $209K *

Join a team that's redefining data architecture and analytics. Leverage your expertise to drive cloud adoption, modernize data platforms, and influence strategic initiatives that empower data-driven d...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $165K *

Transform client relationships by driving revenue growth and satisfaction in healthcare accounts. Collaborate with stakeholders to develop tailored strategies, ensuring long-term partnerships and meas...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$120K - $145K *

Drive the transformation of AI solutions by developing, deploying, and optimizing machine learning models. Collaborate with stakeholders to create innovative applications that enhance patient care whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$78K - $156K *

Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Grow your career with a dynamic role that drives actionable insights across e-commerce and service delivery. Collaborate with stakeholders to analyze data, build impactful reports, and enhance busines...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$102K - $133K *

Unlock potential by optimizing clinical systems and driving informatics initiatives. This role combines strategy with hands-on support across EHR applications, fostering collaboration to enhance workf...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$148K - $256K *

Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$66K - $106K *

Lead the charge in conducting medical record reviews and applying clinical judgment to ensure accurate claim payment decisions while supporting fraud investigations and compliance efforts...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$66K - $106K *

Elevate your career by conducting medical reviews and applying clinical judgment to detect fraud and ensure compliance. Collaborate with agencies to develop cases and support investigations while util...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$92K - $110K *

Empower a dedicated nursing team by leading clinical excellence and fostering a resident-centered culture. Collaborate with facility leadership to enhance care quality and ensure efficient service del...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$124K - $145K *

Join our Client Insights team to transform data into actionable insights that drive sales and merchant retention. Collaborate across analytics, product, and strategy to enhance AI-driven solutions for...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $117K *

Join a team that's building robust data infrastructure to transform raw data into actionable insights. This role is vital for developing scalable data models and pipelines, enhancing decision-making a...

1 week ago

  •   Less than 5 years exp.  •   Transportation

$106K - $120K *

Transform enrollment operations by leading a dynamic team, optimizing processes, and driving performance improvements across multiple companies to enhance efficiency and compliance in a remote environ...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Optimize reimbursement strategies and regulatory compliance by leading analysis, developing policies, and mentoring teams. Drive operational excellence and foster relationships with stakeholders to en...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Unlock potential by driving commercial growth strategies for a product family. Collaborate across teams to translate market insights into actionable plans that enhance revenue, profitability, and cust...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$80K - $95K *

Drive healthcare excellence by overseeing performance improvement initiatives, utilizing Lean and Six Sigma methodologies. Collaborate with leadership to enhance patient care delivery and lead transfo...

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $131K *

Transform IT business processes through analysis and automation, enhancing efficiency and compliance. Leverage tools like Microsoft Power Platform and ServiceNow to align technology with strategic goa...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $142K *

Unlock potential by driving Workday system design and support for Talent Management. Collaborate with teams to analyze needs, implement solutions, and mentor others while managing multiple priorities...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$105K - $142K *

Pioneer innovative solutions by analyzing and enhancing Workday functionality. Collaborate with teams to drive system design, support Talent Management, and mentor peers while managing multiple projec...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Lead feasibility strategy and execution for clinical studies, driving operational excellence and data-driven insights to optimize trial planning and enrollment across rare disease programs. Collaborat...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $125K *

Empower your career by driving the integration and migration of data for a vital financial management system. Collaborate with experts to enhance system reliability and operational efficiency in a ful...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $150K *

Unlock potential by leading the full sales cycle in healthcare, engaging C-suite executives and driving strategic decisions. Leverage your experience to meet quotas, build account strategies, and enha...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Healthcare

$64K - $96K *

Engage in comprehensive risk adjustment audits and compliance reviews, ensuring accurate data submission to CMS. Collaborate with coding teams and management to uphold regulatory standards and improve...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.