Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$175K - $210K *

Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$85K - $97K *

Join a dedicated nursing team to deliver exceptional care, supervise staff, and enhance resident well-being through effective communication and collaboration. Embrace a rewarding role with flexible sh...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$79K - $150K *

Elevate billing processes by overseeing design and governance within Oracle, ensuring efficiency and accuracy in invoicing. Collaborate with cross-functional teams to drive improvements and mentor jun...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Innovate data-driven product strategies by leading informatics initiatives, ensuring rigorous testing and quality assessments while collaborating across teams to enhance client services and streamline...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $150K *

Lead the charge in transforming healthcare systems through data-driven insights and collaborative engagement. Drive performance improvement by managing analytics projects, delivering client solutions...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$86K - $138K *

Champion financial analysis and reporting by conducting in-depth research, preparing forecasts, and collaborating across departments to enhance decision-making and drive business success...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$81K - $100K *

Transform cybersecurity governance by designing and maintaining compliance frameworks. Collaborate with stakeholders to enhance security controls, reduce audit findings, and drive continuous improveme...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $170K *

Optimize financial strategies and drive growth initiatives as a trusted advisor to leadership. Engage in M&A analysis, pricing strategy, and market insights to enhance decision-making in a dynamic Saa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by analyzing healthcare reimbursement systems and translating complex requirements into actionable insights. Collaborate with stakeholders to ensure accurate implementation and suppor...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Transform customer data integration strategies by leveraging your expertise to guide clients in optimizing data flow into the Fusion platform, ensuring reliability and value across complex environment...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Engage in budget management and project support for public health initiatives. Collaborate with program leadership to ensure accurate financial tracking and reporting, while adapting to evolving prior...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Drive program operations support by managing logistics, personnel processes, and documentation for a dynamic public health initiative. Collaborate with leadership to enhance efficiency and ensure comp...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$74K - $102K *

Explore and enhance HR systems by supporting configuration, maintenance, and improvements. Collaborate with stakeholders to resolve issues and drive system enhancements in a dynamic environment focuse...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$92K - $110K *

Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$73K - $110K *

Lead impactful projects to enhance Apptio TBM solutions, driving cost transparency, benchmarking, and strategic planning through collaboration with IT and business partners in a fully remote environme...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $189K *

Elevate your career as a ServiceNow Business Analyst, bridging data analysis and IT modernization. Collaborate with stakeholders to optimize workflows and enhance performance outcomes through actionab...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $90K *

Transform financial insights into strategic initiatives, supporting planning and analysis as the organization scales. Collaborate across teams to enhance budget management, reporting, and performance...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$94K - $129K *

Transform healthcare analytics by leveraging your expertise in data analysis, database management, and visualization tools. Collaborate with teams to optimize workflows and deliver impactful solutions...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Drive impactful medical economics analysis by extracting and synthesizing data to identify trends, enhance financial performance, and support executive decision-making across healthcare operations and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Grow your career with a pivotal role in client relationship management, enhancing membership retention and expanding strategic partnerships through exceptional service and sales expertise in a dynamic...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$66K - $106K *

Join a team that's dedicated to conducting thorough medical reviews and applying clinical judgment to ensure compliance and prevent fraud in healthcare claims. Collaborate with professionals to suppor...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Partner with us to optimize business processes and drive application development. As a Business Analyst, you'll engage with IT and stakeholders to translate requirements into actionable work items, en...

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$52K - $132K *

Champion the future of healthcare integration by resolving complex technical issues, analyzing architectures, and collaborating with teams to enhance interoperability in mission-critical environments...

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Transform the ScriptMed Cloud Platform by designing and deploying scalable solutions. Collaborate with teams to automate workflows and enhance customer onboarding while ensuring compliance with data s...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.