Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$140K - $270K *

Unlock your potential as a Research Scientist, driving AI innovations in healthcare. Collaborate with cross-functional teams to develop and implement cutting-edge machine learning models that enhance...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$149K - $248K *

Drive your career with technical leadership in Palantir Foundry. Lead design, deployment, and enhancement projects for federal health initiatives, ensuring secure and scalable data architecture and op...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$72K - $116K *

Engage in financial analysis and reporting, developing forecasts and insights. Collaborate across departments to enhance business outcomes and present findings to management, driving strategic decisio...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $130K *

Champion change in healthcare IT consulting by leading enterprise software projects and enhancing organizational workflows. Collaborate with leadership, drive client success, and deliver impactful res...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $150K *

Lead the charge in advancing healthcare through innovative HEOR and RWE projects. Collaborate with external partners to deliver actionable insights, utilizing advanced methodologies to tackle complex...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $100K *

Optimize AI service operations by ensuring reliable, secure, and effective support for faculty and staff. Collaborate across teams to implement and maintain cutting-edge technology solutions that enha...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$93K - $141K *

Innovate data solutions by building and maintaining robust pipelines that enhance healthcare data products. Collaborate with cross-functional teams to ensure quality and reliability in data delivery...

Framingham, MARemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$109K - $130K *

Grow your career with a collaborative team focused on innovative healthcare architecture, driving project design and delivery while mentoring talent and ensuring design excellence from concept to cons...

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Optimize GxP IT operations by ensuring effective computer system validation, front-line support, and documentation. Provide expert application support for lab instruments while adhering to regulatory...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$75K - $90K *

Accelerate client success by managing projects and building relationships in a dynamic environment. Collaborate with experts and stakeholders to deliver tailored insights, enhancing client outcomes an...

5 days ago

  •   Less than 5 years exp.  •   Business Services

$113K - $188K *

Shape the future of healthcare reimbursement by developing and implementing payment policies that enhance accuracy, compliance, and provider experience in a dynamic payer environment. Collaborate with...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Analyze financial performance and operational metrics to support strategic growth initiatives. Collaborate with cross-functional teams to enhance reporting accuracy and drive insights for decision-mak...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$119K - $179K *

Lead the charge in architecting FHIR-compliant data models to enhance clinical data integration and usability, supporting patient care and research initiatives across the organization...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Unlock your potential by driving business application solutions and leading requirements elicitation. Collaborate across teams to enhance processes and systems, ensuring alignment with business object...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$131K - $303K *

Join a team that's at the forefront of healthcare analytics, driving innovation and strategy. You will support financial stewardship, operational excellence, and executive communications in a high-vis...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the cybersecurity validation and risk management processes to ensure IT systems comply with requirements, fostering a secure environment while guiding junior team members in their operational tas...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Engage in cutting-edge AI development by designing and scaling intelligent applications. Leverage Generative AI and modern tools to enhance productivity and integrate workflows within healthcare platf...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$73K - $132K *

Join a team that's dedicated to optimizing Epic Professional Billing workflows. Leverage your expertise to analyze, design, and implement solutions while collaborating with stakeholders to enhance ope...

Worcester, MARemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$73K - $132K *

Unlock your potential by leading Epic Professional Billing workflows. Collaborate with stakeholders, optimize systems, and mentor team members while driving impactful solutions in a dynamic healthcare...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $88K *

Lead the design and optimization of Payroll Accounting systems, collaborating with cross-functional teams to enhance Workday Payroll and integrations, ensuring efficient payroll processing, compliance...

Boston, MARemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $88K *

Unlock potential by optimizing payroll systems and processes. Collaborate with cross-functional teams to enhance Workday Payroll capabilities, ensuring compliance and efficiency in payroll accounting...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $93K *

Join a dedicated team as you assess and enhance the nutritional care of residents, developing tailored plans and collaborating with healthcare professionals to improve overall health and well-being in...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$92K - $138K *

Champion complex investigations into fraud, waste, and abuse, leading strategic initiatives to mitigate risks and enhance compliance. Collaborate with teams to develop effective solutions and educate...

4 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.