Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$175K - $210K *

Shape the future of drug development by leading Clinical Pharmacology initiatives, collaborating with cross-functional teams, and driving strategic planning to achieve departmental goals and objective...

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$91K - $163K *

Lead the charge in clinical management, overseeing operations across multiple sites. Foster teamwork and innovation while ensuring patient satisfaction and quality care. Collaborate with leadership to...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $122K *

Unlock potential by leading a dynamic accounting team, managing full-cycle accounting processes, ensuring compliance, and driving process improvements in a fast-paced environment. Collaborate with fin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $102K *

Engage in a dynamic role driving client acquisition in the Home-Based Care sector. You'll build a robust pipeline, execute sales strategies, and collaborate cross-functionally to enhance client experi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $87K *

Deliver strategic leadership in managing resident technology programs, enhancing operational efficiency, and improving resident satisfaction. Collaborate broadly across teams to drive metrics, project...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $150K *

Join a team that's redefining industry partnerships by fostering collaboration between academia and leading organizations. Drive strategic initiatives that enhance research, innovation, and societal i...

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Lead the charge in innovative immunology research, developing novel methods for pathogenic cell depletion. Collaborate across teams to drive discovery and optimize therapeutic strategies, contributing...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$163K - $220K *

Transform vendor strategies and cost management across the organization. Drive financial performance with analytics, lead sourcing events, and collaborate with cross-functional teams to optimize value...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Shape the future of consumer lending by analyzing credit risk and performance data to drive strategic insights for financial institutions, optimizing their underwriting processes and enhancing portfol...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $135K *

Lead the charge in developing precise asset-level forecasts and models for North American power markets. Conduct in-depth research and provide critical insights while mentoring junior analysts and bri...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$90K - $152K *

Unlock data-driven insights by analyzing complex datasets and developing AI-powered solutions. Collaborate with stakeholders to enhance reporting, automate workflows, and drive strategic business deci...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$158K - $197K *

Unlock potential by leading the automation of clinical data integration and dashboard development. Collaborate across teams to enhance data usability and implement AI solutions, ensuring compliance an...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $105K *

Optimize mainframe systems as a key analyst, ensuring stability and performance of IBM z/OS environments. Collaborate with teams to troubleshoot issues and maintain critical applications, while enhanc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $112K *

Elevate your career by providing advanced governance, risk, and compliance support for federal information systems, ensuring compliance with federal laws and regulations while engaging with key stakeh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$212K - $409K *

Drive innovation as a key member of our engineering team, leveraging your expertise in software engineering and data platforms to shape solutions that enhance customer experiences and meet business go...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$132K - $165K *

Drive innovation in oncology diagnostics by leading statistical programming efforts, ensuring data integrity and compliance for clinical trials, while managing a team and collaborating cross-functiona...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive strategic oversight of enterprise-wide RAC audit activities, ensuring compliance and operational excellence. Collaborate with leadership to enhance audit processes, minimize financial risk, and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $106K *

Optimize IT service delivery by managing configuration items, analyzing operational data, and ensuring effective incident resolution. Collaborate with cross-functional teams to enhance service perform...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$90K - $135K *

Shape the future of clinical data solutions by partnering with R&D teams to deliver scalable technology and process improvements, ensuring compliance and operational excellence in biostatistics and cl...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $175K *

Join a team that's transforming software delivery by embedding AI practices across Engineering. Collaborate with cross-functional teams to enhance productivity, automate processes, and drive measurabl...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$133K - $180K *

Help us transform healthcare solutions as you engage with clients, translate complex AI capabilities into actionable plans, and drive successful implementations within a collaborative environment focu...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $177K *

Shape the future of developer tooling by leading strategy and governance for an enterprise ecosystem. Collaborate with cross-functional teams to enhance developer experience, drive automation, and ens...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$180K - $258K *

Shape strategic growth and client relationships across territories by developing tailored sales strategies and leveraging data insights to maximize business impact and foster long-term value in the bi...

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $225K *

Pioneer innovative research strategies to enhance clinical outcomes and drive impactful insights through collaboration across teams, while establishing a robust research infrastructure and publication...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$129K - $177K *

Develop and enhance reinforcement learning policies, ensuring optimal decisioning for healthcare outcomes. Manage the full RL lifecycle from data engineering to production deployment, elevating member...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.