Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Gastroenterologist Jobs in South Dakota

Sort By: Relevance

$210K - $250K *

Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$198K - $297K *

Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$156K - $235K *

Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$210K *

Join a dynamic telemedicine team to deliver high-quality, patient-centered care across South Dakota. Enjoy flexible scheduling while managing diverse clinical cases, including primary and urgent care...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Empower healthcare technology by enhancing clinical systems and integrations. Collaborate with IT and business stakeholders to optimize workflows, manage projects, and ensure system performance across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Join a team that's dedicated to transforming patient care through a Whole Health System, managing inpatient medical cases, and collaborating with healthcare professionals to enhance the well-being of...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$250K - $275K *

Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $115K *

Innovate testing strategies and enhance software quality through automated and manual verification. Collaborate across teams to ensure compliance and optimize processes while leveraging AWS and full-s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $206K *

Drive strategic risk management initiatives by leading regulatory audits, enhancing operational processes, and fostering cross-functional collaboration to minimize financial impacts and improve audit...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Serve as a clinical and technical leader, influencing decision-makers and supporting product innovation in interventional healthcare. Engage with key stakeholders and showcase advanced solutions to en...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$210K - $250K *

Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$245K *

Partner with us to redefine virtual primary care, delivering exceptional patient services through innovative telehealth solutions. Join our dedicated team to enhance health accessibility and effective...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $162K *

Join a team that's dedicated to enhancing biomedical service operations. Lead a skilled team of technicians, ensuring high-quality support and customer satisfaction across the Pacific Northwest while...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$210K - $250K *

Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $107K *

Transform data governance operations by driving process adoption, supporting data stewards, and enhancing governance tools. Collaborate with teams to ensure compliance, improve workflows, and leverage...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$189K - $256K *

Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $138K *

Help us enhance clinical education by delivering expert training and support to healthcare professionals. Drive product adoption and optimize user competencies while fostering strong relationships wit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Shape the future of oncology by leading biologics process development and manufacturing. Collaborate across teams to ensure compliance and quality in clinical-stage products, while mentoring scientist...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$241K - $337K *

Transform your career with a flexible role in primary care, serving a diverse patient population. Collaborate with a dedicated team in a supportive environment, offering both part-time and full-time o...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $220K *

Drive clinical excellence by providing medical expertise across therapeutic areas, ensuring safety and integrity in clinical trials. Collaborate with project teams and senior management to enhance cli...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $175K *

Lead community engagement initiatives to enhance patient advocacy for Becker Muscular Dystrophy. Collaborate with local organizations, educate patients, and build networks to ensure access to quality...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.