Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$121K - $155K *

Lead integrated campaigns and client relationships, driving strategy and execution across teams. Foster collaboration, optimize performance, and ensure client satisfaction while managing budgets and t...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Media

$160K - $200K *

Transform service delivery by leading high-performance teams, ensuring client satisfaction, and driving strategic initiatives. Collaborate across departments to enhance practice management and achieve...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$132K - $188K *

Elevate your career by owning product strategy and execution for AI Gateway capabilities, ensuring seamless connectivity across the AI ecosystem while collaborating with cross-functional teams to driv...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$105K - $140K *

Join us to optimize the commercial operating plan for small accounts, enhancing customer experiences and driving measurable growth through hands-on strategies and collaboration across teams...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$125K - $170K *

Lead the charge in managing complex contracts for a major program, ensuring compliance and strategic alignment. Collaborate with teams to develop proposals, negotiate terms, and maintain strong relati...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $100K *

Join a dynamic team to manage complex projects, ensuring quality control and timely deliverables while coordinating with engineers and stakeholders. Drive continuous improvement and provide analytical...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $185K *

Elevate your career by managing a dynamic data engineering team, shaping scalable data pipelines, and driving innovative data solutions to enhance enterprise data strategies and execution efficiency a...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Drive the success of Abacum implementation projects, managing end-to-end delivery while collaborating with sales and partners to ensure client satisfaction and value realization on the platform...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$157K - $212K *

Lead the charge in enhancing AI search functionality, empowering legal professionals to seamlessly find documents. Collaborate with engineering teams to optimize search relevance, performance, and use...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$148K - $256K *

Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$137K - $231K *

Empower your career by shaping design systems that enhance user experience. Collaborate with teams to build high-quality, interactive UI across platforms, ensuring accessibility and performance while...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$82K - $182K *

Lead strategic initiatives by connecting technology investments to business goals, ensuring effective governance and measurable outcomes. Collaborate cross-functionally to enhance operational efficien...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$181K - $263K *

Manage and develop a high-performing engineering team while overseeing deployment, scaling, and operational health of cloud infrastructure. Drive architectural design of APIs and ensure platform relia...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Transportation

$65K - $100K *

Transform construction projects by managing all phases from planning to completion. Collaborate with diverse teams to ensure quality, safety, and client satisfaction while preparing accurate estimates...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$117K - $152K *

Shape the future of data delivery by managing cross-functional initiatives, ensuring timely execution and governance of data and model projects while collaborating with diverse teams to enhance operat...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$152K - $259K *

Shape the future of global People Operations by leading a dynamic team to innovate and streamline processes, enhancing the employee experience through technology and strategic partnerships across func...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Elevate customer solutions from pre-sale to ownership transfer, ensuring project feasibility, risk management, and effective communication. Collaborate with teams to optimize site execution and delive...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$250K - $275K *

Transform the future of drug development by leading Analytical Development for small molecules and oligonucleotides. Drive scientific strategy, build a high-performing team, and ensure regulatory read...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $130K *

Lead the charge in overseeing field installation activities, ensuring safety and quality while coordinating with project managers and stakeholders to drive successful project execution and adherence t...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Join a dynamic team to optimize clinical operations, ensuring compliance and performance excellence. Lead and develop Clinical Research Associates while managing resources and enhancing training initi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$171K - $251K *

Drive the future of email integrations by leading strategic initiatives, collaborating with cross-functional teams, and transforming complex challenges into scalable solutions that enhance customer ex...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Transportation

$112K - $195K *

Accelerate progress at digital modernization initiatives by leading human-centered product design. Collaborate with diverse teams to enhance workflows, automate processes, and create AI-enabled experi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K - $170K *

Transform the Energy Storage landscape by driving innovative product solutions and fostering strategic partnerships. Leverage your expertise to identify market opportunities and lead initiatives that...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Help us enhance federal human capital operations through independent analysis, strategic recommendations, and effective program delivery. Collaborate on data-driven insights to improve efficiency and...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$157K - $184K *

Empower secure software delivery by designing and maintaining robust CI/CD pipelines, enhancing cloud-native product security, and implementing best practices in software supply chain security. Collab...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.