Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$120K - $145K *

Shape the future of data collaboration by leading product strategy for clean rooms and data delivery platforms. Drive innovation in privacy-conscious solutions while ensuring scalability and alignment...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Drive strategic transformation by leading Record-to-Report functions, enhancing service quality, and implementing best practices across Financial Systems Consulting to achieve world-class operational...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $150K *

Elevate your career by leading a dynamic team in transforming cloud and application security. Drive innovative AI-driven DevSecOps strategies while ensuring compliance and fostering collaboration acro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Advance your career by architecting and implementing production-grade software systems for high-stakes operational tools, ensuring clarity and usability for critical decision-making processes...

3 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$130K - $150K *

Optimize critical infrastructure operations by managing MEP systems and leading maintenance efforts for data centers, ensuring maximum uptime and seamless collaboration across teams to drive business...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$178K - $210K *

Empower your career by driving value for customers through data-driven insights and strategic engagement. Collaborate across teams to articulate and measure the financial impact of our AI platform, en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Help us redefine insurance technology by leading a product team focused on complex, regulated systems. Drive platform strategies, enhance operational capabilities, and collaborate with cross-functiona...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Advance your career by driving market intelligence and product strategy for RUO oncology and transplant products. Collaborate with cross-functional teams to enhance customer relationships and ensure s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dynamic team to evaluate strategic investments and growth opportunities in healthcare. Leverage market insights and financial modeling to shape multi-year business strategies, collaborating acr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $135K *

Join us to lead and enhance healthcare staffing operations, driving growth and performance through strategic recruitment, client management, and team leadership. Collaborate across departments to achi...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Staffing

$75K - $95K *

Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Join a dynamic team to shape the future of multifamily debt strategy, ensuring asset protection and optimizing financing across acquisitions and refinances while driving investor returns through disci...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$164K - $246K *

Unlock potential by driving customer transformation and success in strategic accounts. Leverage your leadership skills to enhance value across deployments, ensuring satisfaction and optimizing the ado...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$180K - $220K *

Drive clinical excellence by providing medical expertise across therapeutic areas, ensuring safety and integrity in clinical trials. Collaborate with project teams and senior management to enhance cli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$121K - $155K *

Lead integrated campaigns and client relationships, driving strategy and execution across teams. Foster collaboration, optimize performance, and ensure client satisfaction while managing budgets and t...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Media

$160K - $200K *

Transform service delivery by leading high-performance teams, ensuring client satisfaction, and driving strategic initiatives. Collaborate across departments to enhance practice management and achieve...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$132K - $188K *

Elevate your career by owning product strategy and execution for AI Gateway capabilities, ensuring seamless connectivity across the AI ecosystem while collaborating with cross-functional teams to driv...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$105K - $140K *

Join us to optimize the commercial operating plan for small accounts, enhancing customer experiences and driving measurable growth through hands-on strategies and collaboration across teams...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$125K - $170K *

Lead the charge in managing complex contracts for a major program, ensuring compliance and strategic alignment. Collaborate with teams to develop proposals, negotiate terms, and maintain strong relati...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $100K *

Join a dynamic team to manage complex projects, ensuring quality control and timely deliverables while coordinating with engineers and stakeholders. Drive continuous improvement and provide analytical...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $185K *

Elevate your career by managing a dynamic data engineering team, shaping scalable data pipelines, and driving innovative data solutions to enhance enterprise data strategies and execution efficiency a...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Drive the success of Abacum implementation projects, managing end-to-end delivery while collaborating with sales and partners to ensure client satisfaction and value realization on the platform...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$157K - $212K *

Lead the charge in enhancing AI search functionality, empowering legal professionals to seamlessly find documents. Collaborate with engineering teams to optimize search relevance, performance, and use...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$148K - $256K *

Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$137K - $231K *

Empower your career by shaping design systems that enhance user experience. Collaborate with teams to build high-quality, interactive UI across platforms, ensuring accessibility and performance while...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.