Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$130K - $150K *
Optimize critical infrastructure operations by managing MEP systems and leading maintenance efforts for data centers, ensuring maximum uptime and seamless collaboration across teams to drive business...
Reposted 2 weeks ago
$178K - $210K *
Empower your career by driving value for customers through data-driven insights and strategic engagement. Collaborate across teams to articulate and measure the financial impact of our AI platform, en...
1 week ago
Director of Product, Insurance Platform
$150K - $180K *
Help us redefine insurance technology by leading a product team focused on complex, regulated systems. Drive platform strategies, enhance operational capabilities, and collaborate with cross-functiona...
1 month ago
Director Product Market Development
$135K - $160K *
Advance your career by driving market intelligence and product strategy for RUO oncology and transplant products. Collaborate with cross-functional teams to enhance customer relationships and ensure s...
1 week ago
$110K - $130K *
Join a dynamic team to evaluate strategic investments and growth opportunities in healthcare. Leverage market insights and financial modeling to shape multi-year business strategies, collaborating acr...
3 weeks ago
$125K - $135K *
Join us to lead and enhance healthcare staffing operations, driving growth and performance through strategic recruitment, client management, and team leadership. Collaborate across departments to achi...
3 weeks ago
$75K - $95K *
Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...
2 days ago
Director, Debt Capital Markets
$150K - $180K *
Join a dynamic team to shape the future of multifamily debt strategy, ensuring asset protection and optimizing financing across acquisitions and refinances while driving investor returns through disci...
Yesterday
Principal Managing Partner - State & Local and Higher Ed (SLED)
$164K - $246K *
Unlock potential by driving customer transformation and success in strategic accounts. Leverage your leadership skills to enhance value across deployments, ensuring satisfaction and optimizing the ado...
Reposted 2 weeks ago
Medical Director, General Medicine
$180K - $220K *
Drive clinical excellence by providing medical expertise across therapeutic areas, ensuring safety and integrity in clinical trials. Collaborate with project teams and senior management to enhance cli...
1 week ago
$121K - $155K *
Lead integrated campaigns and client relationships, driving strategy and execution across teams. Foster collaboration, optimize performance, and ensure client satisfaction while managing budgets and t...
2 days ago
$160K - $200K *
Transform service delivery by leading high-performance teams, ensuring client satisfaction, and driving strategic initiatives. Collaborate across departments to enhance practice management and achieve...
Reposted 4 days ago
Senior Product Manager - AI Gateway
$132K - $188K *
Elevate your career by owning product strategy and execution for AI Gateway capabilities, ensuring seamless connectivity across the AI ecosystem while collaborating with cross-functional teams to driv...
Reposted 5 days ago
Senior E-Commerce & Small Account Growth Manager
$105K - $140K *
Join us to optimize the commercial operating plan for small accounts, enhancing customer experiences and driving measurable growth through hands-on strategies and collaboration across teams...
2 days ago
$125K - $170K *
Lead the charge in managing complex contracts for a major program, ensuring compliance and strategic alignment. Collaborate with teams to develop proposals, negotiate terms, and maintain strong relati...
6 days ago
$80K - $100K *
Join a dynamic team to manage complex projects, ensuring quality control and timely deliverables while coordinating with engineers and stakeholders. Drive continuous improvement and provide analytical...
3 weeks ago
$140K - $185K *
Elevate your career by managing a dynamic data engineering team, shaping scalable data pipelines, and driving innovative data solutions to enhance enterprise data strategies and execution efficiency a...
Reposted 4 days ago
$110K - $130K *
Drive the success of Abacum implementation projects, managing end-to-end delivery while collaborating with sales and partners to ensure client satisfaction and value realization on the platform...
1 week ago
$157K - $212K *
Lead the charge in enhancing AI search functionality, empowering legal professionals to seamlessly find documents. Collaborate with engineering teams to optimize search relevance, performance, and use...
Reposted 2 weeks ago
$148K - $256K *
Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...
Reposted 1 week ago
$137K - $231K *
Empower your career by shaping design systems that enhance user experience. Collaborate with teams to build high-quality, interactive UI across platforms, ensuring accessibility and performance while...
1 week ago
Senior Manager, Business Enablement and Delivery
$82K - $182K *
Lead strategic initiatives by connecting technology investments to business goals, ensuring effective governance and measurable outcomes. Collaborate cross-functionally to enhance operational efficien...
Reposted 3 days ago
Cloud Architect, Product Management
$164K - $246K *
Collaborate with cross-functional teams to translate cloud requirements into actionable product strategies, ensuring technical excellence and successful implementations in complex environments...
3 days ago
Manager, Simulation Infrastructure
$181K - $263K *
Manage and develop a high-performing engineering team while overseeing deployment, scaling, and operational health of cloud infrastructure. Drive architectural design of APIs and ensure platform relia...
Reposted 3 weeks ago
$120K - $160K *
Transform communications strategy and execution for a growing organization. Lead branding, messaging, and digital presence to enhance visibility and engagement across diverse audiences, while collabor...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.