Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
1 week ago
Strategic Account Manager - Southeast
$125K - $150K *
Drive strategic growth as you build relationships with C-level executives, lead complex sales cycles, and exceed quotas in selling enterprise-level SaaS solutions to $20bn+ clients while managing a de...
Reposted 3 weeks ago
Manager, Emerging Defense & Sustainment Sales
$164K - $201K *
Drive strategic engagement with key defense contractors while cultivating impactful relationships at all levels, creating competitive plans, and leading mutual opportunities to enhance market presence...
4 weeks ago
$120K - $145K *
Unlock potential by leading qualitative research projects, managing teams, and fostering client relationships. Drive strategic insights and innovative methodologies to enhance research quality and ens...
2 days ago
$100K - $130K *
Partner with us to deliver strategic financial insights that drive business success through effective forecasting, budgeting, and performance analysis, enabling informed decision-making and enhancing...
Reposted 1 week ago
Workday Financials Senior Principal Consultant - Global Application Managed Services (AMS)
$129K - $192K *
The Workday Financials Security Senior Principal Consultant is a dynamic professional responsible for leading HCM workstreams and ensuring operational efficiency within the Workday practice. This role...
Reposted 1 week ago
Capital Originations, Director
$150K - $195K *
Join a dynamic team as you cultivate investor relationships and drive capital growth. Leverage your LIHTC expertise to expand our investor base, manage key accounts, and contribute to impactful afford...
3 weeks ago
$110K - $130K *
Join a dynamic team as a strategic HR Business Partner, supporting global entities. Drive employee relations, performance management, and culture integration while guiding HR initiatives across divers...
Reposted 1 week ago
Associate Director, Enterprise Information Architecture
$143K - $193K *
Accelerate progress at the forefront of data-driven transformation in life sciences. Collaborate with leadership to shape and execute enterprise data architecture initiatives, ensuring scalable, trust...
1 week ago
Sr. Director - Product Operations
$160K - $200K *
Lead the charge in developing and scaling the product operating model, ensuring organizational effectiveness, agile execution, and strategic alignment. Collaborate across teams to foster a culture of...
Reposted 2 weeks ago
Senior Director, Aftermarket Channel-North America
$176K - $220K *
Lead the charge in developing high-performing partnerships and teams to drive growth in North America's aftermarket channel, collaborating across functions to enhance partner performance and customer...
1 week ago
$90K - $100K *
Join a team that's dedicated to enhancing business continuity and operational resilience. Collaborate across departments to develop and maintain effective continuity plans, ensuring readiness for disr...
2 days ago
eHealth Exchange Onboarding Program Manager
$100K - $120K *
Unlock potential by guiding health systems through the eHealth Exchange onboarding process. Ensure seamless implementation, provide exceptional customer service, and enhance interoperability in health...
2 days ago
Managing Director, Go-to-Market Value Creation
$210K - $250K *
Drive portfolio value creation through strategy execution, leveraging your extensive experience in revenue growth and go-to-market capabilities to lead engagements and mentor GTM teams across technolo...
Reposted 1 week ago
Project Manager, Client Services (Fri-Mon ET or CT 10 hour days)
$90K - $110K *
Optimize eDiscovery project management by driving workflows, ensuring quality, and meeting litigation requests. Collaborate with teams to enhance processes and maintain stakeholder communication for s...
1 week ago
Senior Director, Corporate FP&A | United States | Remote
$260K - $312K *
Elevate your career by leading Corporate FP&A initiatives in a high-growth environment. Drive strategic financial planning, forecasting, and reporting while building a robust financial infrastructure...
Today
Strategic Account Manager, Business Clients (FX & Payments)
$85K - $98K *
Transform client relationships by owning a portfolio of B2B accounts, driving growth through tailored solutions in FX and payments, and leveraging technology for impactful service delivery...
1 week ago
Director, Global Business Resiliency
$150K - $180K *
Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...
Reposted 3 days ago
$150K - $180K *
Lead a high-performance engineering team, driving strategy and innovation for Corporate Payments services while aligning technology with business goals. Foster collaboration and continuous improvement...
Reposted 3 days ago
Workday Financials Senior Principal Consultant, Accounting Center - Global AMS
$128K - $192K *
The Workday Financials Senior Principal Consultant, Record to Report is a seasoned professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday Financi...
Reposted 1 week ago
Director, NDD Business Development: Neurology Clinics
$162K - $224K *
Drive growth in the Neurodegenerative Disease sector by developing strategic partnerships with health systems and academic centers, leveraging existing relationships to create innovative solutions tha...
1 week ago
$170K - $180K *
Transform quality management across renewable energy projects by leading initiatives that enhance processes, ensure compliance, and drive continuous improvement. Collaborate with cross-functional team...
2 days ago
Senior Manager, Corporate Strategy
$125K - $150K *
Empower strategic decision-making by driving data analysis and recommendations. Collaborate with senior leadership to shape initiatives, build financial models, and leverage AI tools, ensuring impactf...
5 days ago
Principal, Global PX Operations Lead
$126K - $276K *
Drive impactful transformation in People Experience operations by leading the redesign of HR service delivery through ServiceNow and AI automation. Own the reporting and service model architecture tha...
Reposted 1 week ago
Manager, Software Engineering (Loans Lifecycle)
$204K - $264K *
Lead the charge in shaping technical strategy and fostering a culture of quality within your team, ensuring operational excellence and collaboration across product development to drive impactful busin...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.