Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$110K - $130K *
Shape multi-year commodity strategies for electrical equipment, ensuring robust supplier negotiations and capacity management. Collaborate with engineering to optimize designs and mitigate risks throu...
1 week ago
Director of Provider Analytics
$138K - $201K *
Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...
2 weeks ago
$129K - $177K *
Lead a dynamic sales team to drive growth, enhance customer relations, and achieve profitability goals. Collaborate across functions to execute strategies and cultivate talent while ensuring top-tier...
3 weeks ago
Head of Software Systems & Business Enablement
$180K - $220K *
Unlock potential by leading software systems management and optimization across a global portfolio. Collaborate with business and technology leaders to enhance operational efficiency, drive innovation...
1 week ago
Manager, Client Onboarding & Operations
$145K - $160K *
Shape exceptional client experiences by leading onboarding and operations. Collaborate with cross-functional teams to manage complex projects, ensuring timely delivery and exceeding client expectation...
3 weeks ago
Principal, Cloud Solutions Architect
$208K - $235K *
Join a dynamic team to architect scalable cloud solutions, ensuring high engineering standards while collaborating with cross-functional stakeholders to drive innovation and governance in a fast-paced...
3 weeks ago
Director, Group Leader, BeOne Institute - San Carlos, California
$236K - $295K *
Lead the charge in advancing breakthrough discoveries by guiding a high-performing research team. Set strategic goals, foster collaboration, and translate innovative ideas into transformative medicine...
2 weeks ago
$125K - $220K *
Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...
2 weeks ago
$105K - $110K *
Transform quality management across multiple facilities by driving compliance, enhancing food safety, and leading improvement initiatives. Collaborate with diverse teams to ensure product excellence a...
2 weeks ago
$149K - $248K *
Champion client engagement and operational excellence by managing consulting teams, driving quality standards, and fostering relationships within Military Health Systems. Lead new business development...
1 week ago
Senior Director of Commercial Excellence
$192K - $256K *
Oversee high-impact initiatives driving productivity gains in Sales and CS. Blend strategic thinking with hands-on leadership to ensure effective execution of cross-functional programs aligned with AG...
2 days ago
$200K - $240K *
Drive strategic M&A initiatives by leading complex transactions, evaluating opportunities, and collaborating with executives to enhance corporate growth and value creation. Shape the future through ef...
5 days ago
Marketing Manager (Entertainment & Commercial)
$80K - $95K *
Lead the marketing strategy for our Entertainment and Commercial team, managing projects from conception to execution. Collaborate with cross-functional teams to create impactful sales materials, supp...
1 week ago
Manager/Senior Manager, Autonomous Enterprise Consulting
$135K - $160K *
Transform client businesses by leading AI strategy and implementation. Drive impactful consulting engagements, build trusted relationships, and leverage emerging technologies to deliver measurable out...
3 days ago
Transaction Advisory Services Manager
$117K - $158K *
Help us advance financial analysis by evaluating deal structures, managing projects, and delivering insights. Engage with clients, enhance value through collaboration, and lead junior team members to...
Reposted 1 week ago
Director, Skills & Marketplace Ecosystem
$119K - $186K *
Lead the charge in shaping a skills-powered talent ecosystem, driving strategy and governance for enterprise skills and talent marketplace initiatives that enhance workforce planning and career growth...
Reposted 2 weeks ago
Manager FP&A - Private Equity Advisory
$110K - $130K *
Elevate your career by partnering with clients to enhance FP&A processes, build financial models, and drive operational improvements in a dynamic Private Equity environment. Collaborate with teams to...
5 days ago
$110K - $130K *
Drive go-to-market strategy for AI-powered healthcare solutions, collaborating cross-functionally to enhance product positioning, messaging, and performance. Own marketing execution and leverage insig...
6 days ago
$90K - $110K *
Grow your career with a dynamic team driving revenue through strategic business development in diverse markets. Build relationships, lead pursuits, and analyze trends to secure projects that shape com...
2 weeks ago
Manager, Efficacy and Insights
$100K - $120K *
Champion strategic research initiatives to enhance product efficacy and student success. Collaborate cross-functionally to drive impactful studies, mentor a growing team, and translate findings into a...
2 weeks ago
Senior Manager of Strategic Staffing
$161K - $189K *
Drive the hiring engine for high-volume staffing engagements, leading a team to optimize recruitment processes, ensure client satisfaction, and meet ambitious fill-rate and time-to-fill goals while ma...
2 weeks ago
Manager, Market Intelligence & Commercial Analytics
$110K - $130K *
Lead the charge in market intelligence and sales support, bridging teams to drive insights and strategies in U.S. power markets. Collaborate cross-functionally to identify opportunities and enhance cu...
1 week ago
Delivery Director-Telecommunications-ServiceNow TSOM, CSM, TI, FSM, OSS, BSS
$150K - $180K *
Lead the charge in driving operational excellence and portfolio growth, ensuring customer satisfaction and seamless delivery across innovative projects. Collaborate with sales and project teams to ele...
Reposted 1 week ago
Director, Ohio Transportation Infrastructure
$157K - $283K *
Unlock your leadership potential as you drive innovative transportation projects in Ohio. Collaborate with stakeholders to enhance infrastructure, optimize project delivery, and lead a dynamic team to...
Reposted 2 weeks ago
$171K - $269K *
Lead the charge in defining and evolving data architecture and engineering standards for scalable, secure enterprise data platforms. Collaborate across teams to deliver reliable, actionable data produ...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.