Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$110K - $130K *

Shape multi-year commodity strategies for electrical equipment, ensuring robust supplier negotiations and capacity management. Collaborate with engineering to optimize designs and mitigate risks throu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$129K - $177K *

Lead a dynamic sales team to drive growth, enhance customer relations, and achieve profitability goals. Collaborate across functions to execute strategies and cultivate talent while ensuring top-tier...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$180K - $220K *

Unlock potential by leading software systems management and optimization across a global portfolio. Collaborate with business and technology leaders to enhance operational efficiency, drive innovation...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$145K - $160K *

Shape exceptional client experiences by leading onboarding and operations. Collaborate with cross-functional teams to manage complex projects, ensuring timely delivery and exceeding client expectation...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$208K - $235K *

Join a dynamic team to architect scalable cloud solutions, ensuring high engineering standards while collaborating with cross-functional stakeholders to drive innovation and governance in a fast-paced...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$236K - $295K *

Lead the charge in advancing breakthrough discoveries by guiding a high-performing research team. Set strategic goals, foster collaboration, and translate innovative ideas into transformative medicine...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $220K *

Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $110K *

Transform quality management across multiple facilities by driving compliance, enhancing food safety, and leading improvement initiatives. Collaborate with diverse teams to ensure product excellence a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$149K - $248K *

Champion client engagement and operational excellence by managing consulting teams, driving quality standards, and fostering relationships within Military Health Systems. Lead new business development...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$192K - $256K *

Oversee high-impact initiatives driving productivity gains in Sales and CS. Blend strategic thinking with hands-on leadership to ensure effective execution of cross-functional programs aligned with AG...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$200K - $240K *

Drive strategic M&A initiatives by leading complex transactions, evaluating opportunities, and collaborating with executives to enhance corporate growth and value creation. Shape the future through ef...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the marketing strategy for our Entertainment and Commercial team, managing projects from conception to execution. Collaborate with cross-functional teams to create impactful sales materials, supp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Transform client businesses by leading AI strategy and implementation. Drive impactful consulting engagements, build trusted relationships, and leverage emerging technologies to deliver measurable out...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$117K - $158K *

Help us advance financial analysis by evaluating deal structures, managing projects, and delivering insights. Engage with clients, enhance value through collaboration, and lead junior team members to...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$119K - $186K *

Lead the charge in shaping a skills-powered talent ecosystem, driving strategy and governance for enterprise skills and talent marketplace initiatives that enhance workforce planning and career growth...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by partnering with clients to enhance FP&A processes, build financial models, and drive operational improvements in a dynamic Private Equity environment. Collaborate with teams to...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Drive go-to-market strategy for AI-powered healthcare solutions, collaborating cross-functionally to enhance product positioning, messaging, and performance. Own marketing execution and leverage insig...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Grow your career with a dynamic team driving revenue through strategic business development in diverse markets. Build relationships, lead pursuits, and analyze trends to secure projects that shape com...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $120K *

Champion strategic research initiatives to enhance product efficacy and student success. Collaborate cross-functionally to drive impactful studies, mentor a growing team, and translate findings into a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$161K - $189K *

Drive the hiring engine for high-volume staffing engagements, leading a team to optimize recruitment processes, ensure client satisfaction, and meet ambitious fill-rate and time-to-fill goals while ma...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in market intelligence and sales support, bridging teams to drive insights and strategies in U.S. power markets. Collaborate cross-functionally to identify opportunities and enhance cu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Lead the charge in driving operational excellence and portfolio growth, ensuring customer satisfaction and seamless delivery across innovative projects. Collaborate with sales and project teams to ele...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$157K - $283K *

Unlock your leadership potential as you drive innovative transportation projects in Ohio. Collaborate with stakeholders to enhance infrastructure, optimize project delivery, and lead a dynamic team to...

RemoteRemote

Reposted 2 weeks ago

  •   15+ years exp.  •   Real Estate & Construction

$171K - $269K *

Lead the charge in defining and evolving data architecture and engineering standards for scalable, secure enterprise data platforms. Collaborate across teams to deliver reliable, actionable data produ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.