Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$206K - $413K *

Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$190K - $215K *

Champion the future of energy development by leading regional strategies, managing utility relationships, and driving contract negotiations. This role balances strategic oversight with tactical execut...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$164K - $205K *

Elevate scientific rigor in real-world evidence development. Collaborate with cross-functional teams to ensure agent conceptualization and evaluation meet scientific standards, driving impactful solut...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Grow your career by driving sales and developing strategic relationships within major sectors across the AMER region, ensuring revenue maximization and effective execution of account strategies...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$140K - $170K *

Champion the future of customer engagement by leading lifecycle marketing strategies. Drive retention and loyalty through data-driven personalization across multiple channels, maximizing customer life...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $115K *

Advance the payroll function for a diverse workforce, ensuring compliance and accuracy across multiple states. This hands-on role requires expertise in payroll systems and regulations, driving process...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$110K - $145K *

Champion innovative solutions as a Senior Business Analyst, driving requirements gathering and Agile processes to enhance custom applications for DHS. Collaborate with teams to streamline operations a...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Shape high-impact growth in retail partnerships by overseeing field operations, driving application volume, and enhancing point-of-sale conversion rates. Collaborate with teams to optimize strategies...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Join our team as a Senior Value Engineer, where you'll drive strategic deals by building economic cases that resonate with CFOs, blending financial modeling with executive engagement to deliver impact...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Lead the charge in designing and executing rail projects, ensuring compliance and quality. Collaborate with multidisciplinary teams and strengthen client relationships while managing project delivery...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $105K *

Partner with us to provide exceptional administrative support to a VP, managing complex calendars, travel logistics, and cross-functional relationships while ensuring smooth operations and effective c...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $180K *

Drive operational excellence by managing the leadership team's cadence, metrics, and contract operations. This hands-on role blends business judgment with execution, ensuring alignment and efficiency...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$98K - $120K *

Join a dynamic team as you lead engineering initiatives, drive process improvements, and collaborate across functions to enhance manufacturing efficiency and quality. Your expertise will shape project...

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Champion strategic HR initiatives that drive organizational design, talent development, and change management. Collaborate with senior leaders to enhance employee experience and align workforce planni...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$137K - $202K *

Shape the future of compensation products by owning the development and management of a comprehensive range-setting tool and analytics roadmap that enhances productivity for Compensation Partners and...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$185K - $205K *

Shape the future of customer success by leading complex SaaS solutions, driving strategic partnerships, and mentoring teams to enhance value delivery and accelerate growth across enterprise accounts...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's redefining payment solutions! Drive strategic product management, leading innovative card offerings and fostering high-performing teams while shaping market-leading strategies and e...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Optimize our Dayforce systems strategy while managing stakeholder relationships. You'll guide HRIS functions, lead an offshore analyst, and ensure effective implementations to drive organizational eff...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$149K - $173K *

Lead quality and food safety initiatives across North America, ensuring compliance and audit readiness. Drive continuous improvement and operational excellence through technical expertise and collabor...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$110K - $130K *

Explore a pivotal role overseeing financial management, budgeting, and compliance. Collaborate with leadership to provide insights that drive operational decisions and ensure organizational sustainabi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$105K - $115K *

Engage with us to lead multiple client implementations, ensuring seamless transitions and high satisfaction. Collaborate cross-functionally, manage project timelines, and mentor team members while dri...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform digital growth strategies by overseeing website, SEO, and campaigns. Drive content distribution, partner marketing, and harness AI for analytics, ensuring effective buyer engagement and meas...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$149K - $173K *

Champion partner success by driving strategic programs, enablement, and cross-functional operations. You'll turn channel strategies into measurable outcomes to expand our partner ecosystem and enhance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Champion product marketing by driving launches, pricing strategies, and sales enablement for key therapy lines. Collaborate cross-functionally to ensure compliance and optimize performance metrics, pa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform strategic initiatives by coordinating and executing projects that enhance organizational effectiveness, support leadership communication, and drive process excellence across departments, ens...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.