Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$176K - $293K *

Develop and implement strategic account plans to drive sales growth and build relationships with key decision-makers in healthcare. Collaborate with cross-functional teams to achieve business goals an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Transform complex cybersecurity narratives into engaging content that captivates audiences across various formats. Collaborate with cross-functional teams to enhance brand storytelling and drive conve...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $175K *

Join a dynamic team to drive the strategy and roadmap for Sales and Marketing platforms, focusing on Salesforce and marketing automation. Collaborate with stakeholders to prioritize initiatives and de...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$199K - $370K *

Lead a dynamic team of Sales Specialists to drive growth and revenue in the Risk sector. Collaborate with leadership to enhance customer engagement, implement strategic solutions, and achieve sales ta...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$150K - $251K *

Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$238K - $357K *

Transform growth strategies by leading AI initiatives, targeting key customers, and driving adoption through innovative partnerships and market insights. Collaborate across teams to enhance product of...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$145K - $156K *

Optimize resource allocation in a dynamic creative studio, ensuring efficient talent management and fostering strong relationships with artists and project leads. Drive proactive planning and problem...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$232K - $348K *

Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's shaping global regulatory strategy for rare disease therapies. In this pivotal role, you'll lead submissions and agency interactions across the US, EU, UK, and Japan, driving execut...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Staffing

$130K - $140K *

Join a team that leads innovative research and policy analysis to advance a clean, affordable, and resilient electricity future. Collaborate with policymakers and stakeholders, translating complex fin...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Energy & Utilities

$155K - $165K *

Help us build and enhance our go-to-market launch system, driving customer engagement and adoption for impactful releases. Collaborate cross-functionally to ensure alignment and seamless communication...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$175K - $210K *

Join a team that's shaping the future of innovation in cancer research by leading financial planning and commercialization efforts to support strategic growth and decision-making across an impactful o...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Hospitals & Medical Centers

$207K - $277K *

Lead the charge in enhancing global ERP delivery excellence, driving governance, quality, and continuous improvement across teams. Foster collaboration and optimize resource utilization to ensure pred...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$190K - $230K *

Lead and enhance brand storytelling across campaigns. Collaborate with teams to ensure cohesive brand presence, drive creative direction, and develop a high-performing creative team to elevate brand i...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Champion global clinical trials by leading project teams to deliver excellence on time and within budget, ensuring high-quality outcomes that exceed client expectations in the biotech and pharma secto...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Engage in advanced security operations as a Senior Security Analyst, leading incident response, enhancing detection capabilities, and driving process improvements to protect critical assets in a dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$143K - $193K *

Empower global clinical operations by leading process management initiatives, ensuring compliance and efficiency. Collaborate with cross-functional teams to enhance quality and drive innovations in cl...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead multifamily transactions from sourcing to closing, ensuring disciplined execution and strategic alignment across teams. Drive outcomes through strong negotiation, relationship management, and a r...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$87K - $120K *

Champion business process excellence by bridging stakeholders and IT teams, driving Salesforce solutions, and optimizing workflows to enhance operational efficiency and user experience across the orga...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$255K - $290K *

Drive the technical vision for a complex database platform, ensuring scalability and performance. Lead architecture decisions, mentor engineers, and collaborate across teams to enhance data infrastruc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$165K - $210K *

Drive innovation as you lead a data science team focused on generative AI and machine learning. Shape scalable solutions that address business challenges, leveraging advanced analytics to deliver meas...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$116K - $160K *

Accelerate progress at driving strategic initiatives within Operations and Member Experience. Collaborate with cross-functional teams to deliver impactful solutions, enhance operational efficiency, an...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$160K - $190K *

Join a team that's driving architectural excellence and AI adoption. You'll optimize cloud systems, enhance data processing, and lead engineering teams to innovate and scale efficiently, ensuring robu...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate customer success in the Americas by leading a growing team of CSMs. Drive adoption, value realization, and customer health while shaping playbooks and strategies for scalable growth. Collabora...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform the data platform by owning product direction and delivery. Collaborate across teams to prioritize needs, streamline processes, and ensure engineering focuses on impactful projects while enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.