Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Partner Brand Strategy
$110K - $130K *
Champion brand strategy for a diverse portfolio of university partners. Lead a team to develop positioning, messaging, and creative briefs, ensuring alignment across marketing functions while leveragi...
Today
Senior Technical Product Manager, IT Service Management
$143K - $169K *
Lead the transition to a modern, AI-native ITSM platform, enhancing service management across teams. Drive employee-centric design, streamline workflows, and ensure seamless integration while maintain...
Reposted 1 week ago
$235K - $291K *
Champion strategic leadership across diverse digital and marketing initiatives, guiding cross-disciplinary teams and fostering client relationships to drive impactful solutions and business growth in...
5 days ago
Staff Product Manager, Agentic Planning
$168K - $285K *
Elevate the future of software planning by leading a team that integrates human and AI collaboration. Shape product direction, connect work to business priorities, and drive strategic decisions in a d...
3 days ago
Digital Product Manager - Billings & Payments
$110K - $181K *
Champion impactful technical product strategies, driving customer and business outcomes by collaborating with diverse stakeholders to prioritize solutions, enhance platform performance, and ensure sea...
Reposted 4 days ago
Director, Strategy and Special Projects
$141K - $204K *
Drive strategic growth for DSD by leveraging data, analytics, and tools to enhance operational performance and achieve expansion goals. Collaborate with leadership to support initiatives that elevate...
3 days ago
Executive Director GPO Delivery and Optimization
$164K - $305K *
Champion excellence by leading a high-performing team to optimize GPO delivery, ensuring strategic alignment and value realization across multiple accounts while fostering strong relationships with se...
Reposted today
$144K - $195K *
Innovate and lead the design of identity management solutions, ensuring security and integration across platforms. Collaborate with teams to enhance user experience and manage critical issues in a dyn...
1 week ago
Quality Manager, QMS & Process Excellence
$110K - $172K *
Unlock potential by leading the design and deployment of a global Quality Management System, ensuring compliance and operational excellence across multiple aerospace sites while fostering collaboratio...
2 weeks ago
Senior Manager, Resource Planning: Content
$110K - $130K *
Pioneer operational excellence by driving staffing visibility and standardized planning across diverse content teams. Collaborate with stakeholders to enhance resource management and optimize project...
1 week ago
$115K - $130K *
Transform the contracting process by managing the lifecycle of agreements, ensuring efficient execution while balancing risk and compliance. Collaborate with cross-functional teams to support business...
2 weeks ago
Director, Sales & Operations Planning
$150K - $180K *
Drive operational excellence by leading the S&OP strategy, aligning resources with business goals, and optimizing capacity planning across the network to enhance efficiency and service delivery...
4 days ago
Senior Director, Clinical Quality Assurance (CQA)
$245K - $286K *
Elevate clinical quality assurance through strategic leadership and oversight of global trials, ensuring compliance with GCP regulations. Drive quality culture and inspection readiness while mentoring...
Reposted 3 weeks ago
Lead Software Solutions Architect
$135K - $160K *
Engineer innovative cloud-native solutions by leading architecture design and implementation. Collaborate with cross-functional teams to drive technical strategies while mentoring talent, ensuring pro...
Reposted 3 weeks ago
Digital Product Manager, Tissue Acquisition Experience
$114K - $142K *
Elevate the product roadmap for tissue acquisition by collaborating with stakeholders to enhance user experience and streamline processes. Drive innovation and data-driven decisions to support operati...
5 days ago
Senior Technical Program Manager - Credit & Lending
$162K - $202K *
Oversee end-to-end technology program delivery for credit and lending products, collaborating across multiple teams to ensure compliance and operational readiness while driving strategy and managing r...
Reposted 3 weeks ago
$140K - $187K *
Lead the charge in strategic and operational excellence for substation engineering, overseeing project execution, team development, and client relationships to drive growth and ensure high-quality del...
5 days ago
Senior Director of Growth, Production & Capture
$160K - $200K *
Champion revenue growth by leading proposal operations and capture strategies. Drive compliance and execution across multiple concurrent pursuits while building scalable infrastructure to enhance mark...
3 days ago
$125K - $150K *
Transform product strategy by leading impactful initiatives that enhance user experience and drive growth. Collaborate with cross-functional teams to deliver innovative solutions that delight customer...
5 days ago
Senior Manager, Compliance Advisory & Change Management
$172K - $238K *
Shape compliance strategies by operationalizing key frameworks, guiding stakeholders, and ensuring adherence to regulations. Collaborate across teams to enhance risk management and support product com...
Reposted 5 days ago
Director, GCP Inspection Management- Americas
$172K - $232K *
Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...
2 weeks ago
$280K - $330K *
Empower a dynamic engineering team by leading technical architecture, enhancing system reliability, and driving scalable solutions that support rapid growth in a fast-paced fintech environment. Foster...
Reposted 3 weeks ago
$108K - $162K *
Champion customer support by managing maintenance services and operations. Lead a team to ensure timely resolutions and enhance product performance while utilizing technical expertise and strategic pl...
2 weeks ago
$176K - $293K *
Develop and implement strategic account plans to drive sales growth and build relationships with key decision-makers in healthcare. Collaborate with cross-functional teams to achieve business goals an...
2 weeks ago
$80K - $95K *
Transform complex cybersecurity narratives into engaging content that captivates audiences across various formats. Collaborate with cross-functional teams to enhance brand storytelling and drive conve...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.