Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$113K - $158K *

Lead and optimize digital media delivery across consulting, technology, and client engagement. Drive strategic growth, operational excellence, and team development, ensuring innovative solutions in Go...

RemoteRemote

1 month ago

  •   8 - 10 years exp.  •   Media

$78K - $95K *

Join a team that's driving project success in commercial environments. Support project management tasks, coordinate resources, and ensure compliance while collaborating with diverse stakeholders to ac...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Technical Services

$135K - $160K *

Elevate our deal desk function by transforming processes into a scalable model. You'll implement AI tools, streamline order forms, and ensure efficient deal structuring while collaborating with cross...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$200K - $352K *

Shape the future of marketing compliance by leading automation initiatives, overseeing review processes, and driving collaboration across teams. This hands-on role combines strategic oversight with di...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$105K - $163K *

Lead and manage client-facing teams to deliver high-quality card processing projects, ensuring successful implementations and client satisfaction through effective project management and strategic ove...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $230K *

Manage staffing, capacity planning, and talent development to enhance operational efficiency. Collaborate with cross-functional teams to optimize processes and ensure best practices in electrical desi...

United StatesRemote

Reposted 1 month ago

  •   11 - 15 years exp.  •   Technical Services

$120K - $193K *

Transform enterprise security by leading product strategy and delivery, focusing on data protection and compliance. Drive innovation through AI integration, ensuring scalable solutions that meet evolv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $250K *

Shape the future of global sales strategy by leading initiatives that drive partner growth and sales enablement. Collaborate with cross-functional teams to optimize processes, enhance capabilities, an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $140K *

Join our team to shape innovative industrial solutions, driving product strategy and execution. You'll lead cross-functional efforts, ensuring compliance and safety while delivering impactful products...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$135K - $160K *

Transform our growth marketing strategy by driving demand generation and managing a high-performing team. Collaborate with cross-functional leaders to optimize pipeline performance and leverage automa...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$202K - $304K *

Shape operational strategies for complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development, budget creation, and client engagement, while mentoring c...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Healthcare

$143K - $179K *

Shape and lead client implementations for a cutting-edge trading platform, guiding asset and wealth managers through system configuration and go-live processes while ensuring client satisfaction and p...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Healthcare

$75K - $105K *

Tackle comprehensive project management for onboarding HME providers, driving digital transformation across healthcare. Collaborate strategically, enhance platform adoption, and leverage data insights...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K *

Lead the charge in driving growth strategies for large omnichannel merchants, while optimizing partnerships and implementing actionable plans. Collaborate with stakeholders to deliver measurable ROI a...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Optimize client success by leading strategic relationships and enhancing revenue cycle performance. Drive measurable improvements, manage escalations, and ensure value realization across healthcare so...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $198K *

Lead architectural vision for luxury developments, guiding projects from acquisition to delivery. Collaborate with teams to ensure design integrity and quality across the portfolio while advising exec...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $145K *

Lead the charge in shaping and expanding bridge design services across New England. Provide strategic direction, oversee project delivery, mentor staff, and strengthen client relationships to enhance...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$112K - $126K *

Join us to lead strategic investments in Service Engineering and Technical Publications, driving innovation through AI technologies. Collaborate with cross-functional teams to enhance product lifecycl...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Unlock potential by leveraging your Salesforce expertise to design, build, and review secure, scalable solutions. Collaborate with clients and teams to ensure seamless integrations and effective deliv...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Join a dynamic team to lead the development of innovative Microsoft-based platforms, driving modernization and AI integration while ensuring robust, scalable, and secure solutions in a highly regulate...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Accelerate product strategy and delivery in an evolving security landscape. Own roadmap execution, collaborate with engineering, and engage with customers to build trust and drive innovation. Measure...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Empower your career by leading a remote team in managing healthcare operations and compliance for a Federal IDRE program. Drive performance, enhance quality, and ensure regulatory adherence while fost...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Champion preconstruction initiatives for large-scale commercial projects, ensuring accurate estimates, client satisfaction, and alignment with company goals through effective communication and relatio...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Transform frontline manager development by leading strategic programs that enhance coaching, deal inspection, and pipeline management. Collaborate cross-functionally to drive consistent team performan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.