Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Operations Manager, Global Strategic Accounts
$130K - $160K *
Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...
1 week ago
Senior Manager, Programs - Global Expansion and New Initiatives
$173K - $255K *
Empower global expansion by leading customer operations strategy, managing complex programs, and driving continuous improvement across international markets. Collaborate with cross-functional teams to...
2 weeks ago
Senior Account Manager, Promotional Medical Education
$85K - $95K *
Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...
6 days ago
Product Manager, New Content Initiatives and Analysis
$140K - $175K *
Transform investment research by evaluating and integrating diverse datasets, enhancing AI-driven workflows, and driving strategic content initiatives to elevate platform value and user experience...
2 days ago
$115K - $168K *
Lead the charge in federal grant management for the 988 Suicide & Crisis Lifeline, overseeing compliance, budgeting, and operations. Collaborate across teams to ensure effective grant administration a...
2 weeks ago
$180K - $200K *
Lead the charge in driving growth marketing strategies across segments, crafting integrated campaigns and events. Ensure alignment with business goals while managing a talented multidisciplinary team...
Reposted 1 month ago
Senior Manager, Strategic Bank Capital
$200K - $300K *
Join a dynamic team to manage bank capital relationships, drive coverage strategies, and support capital formation initiatives. This role offers growth opportunities in a fast-paced environment, focus...
1 week ago
Senior Project Manager - Marine Structures
$110K - $130K *
Join a dynamic team as you lead complex marine inspection projects, ensuring technical excellence and strong client relationships while mentoring staff and managing multi-disciplinary teams across div...
Reposted 1 month ago
Senior Manager, Finance & Strategy - Go-To-Market
$183K - $228K *
Drive strategic financial insights as a key partner to the go-to-market teams, owning revenue forecasts and investment economics. Collaborate with leadership to shape long-term growth strategies and e...
Reposted 2 weeks ago
$100K - $130K *
Support the financial planning and analysis for Executive Leadership, encompassing budgeting, forecasting, and reporting. Collaborate cross-functionally to drive profitability through data-driven insi...
Reposted 1 week ago
AEC Healthcare Project Manager
$110K - $130K *
Shape the future of healthcare by leading complex architectural and facility projects, ensuring optimal client service and regulatory compliance throughout all project phases while guiding multidiscip...
Reposted 3 days ago
$150K - $180K *
Accelerate brand transformation by leading a dedicated creative team, ensuring high-quality visual and verbal expression across global campaigns and touchpoints to create memorable customer experience...
3 weeks ago
Senior Manager, Revenue Operations
$156K - $195K *
Own the end-to-end B2B2C enrollment funnel by transforming data into actionable insights, optimizing processes, and leading cross-functional collaboration to enhance growth and ensure successful membe...
Reposted 3 weeks ago
Senior Technical Manager-Archaeologist
$100K - $130K *
Lead complex archaeological projects, ensuring technical quality and client satisfaction. Mentor staff, develop methodologies, and manage budgets while fostering strong client relationships and suppor...
2 weeks ago
$165K - $175K *
Unlock potential by leading enterprise data engineering initiatives, driving platform modernization, and enhancing operational excellence. Collaborate with cross-functional teams to deliver scalable...
Reposted 3 days ago
Director, Commercial Planning & Excellence
$170K - $180K *
Lead the strategic execution of commercial planning and sales coverage, aligning cross-functional teams to drive profitable growth. Oversee territory design, customer segmentation, and annual planning...
2 weeks ago
Director, Centralized Case Management
$110K - $130K *
Elevate your career by providing strategic leadership for a national remote case management team, ensuring service excellence, operational consistency, and client satisfaction while collaborating with...
2 weeks ago
Product Manager, File and Remit
$120K - $145K *
Transform the future of tax compliance by building a scalable filing platform and remittance infrastructure, enabling seamless global transactions and automation for international sellers. Drive innov...
2 weeks ago
Director, Data & Distribution Partnerships
$190K - $275K *
Advance the Data & Distribution Partnerships function by innovating and scaling data reseller and distribution models, building commercial arrangements, and leading a team to create revenue-generating...
Reposted 2 weeks ago
$120K - $145K *
Drive impactful program management by leading cross-functional initiatives, ensuring alignment with strategic goals, and delivering measurable results in a dynamic environment. Collaborate effectively...
3 days ago
Associate Director, Scheduling- Civil Infrastructure Construction
$175K - $220K *
Join a team that's shaping infrastructure projects through expert scheduling leadership. Your strategic planning and risk management skills will optimize resource use and ensure timely delivery in a c...
Reposted 2 days ago
Sr. Engineering Director, Supply Chain and Order Management Systems
$205K - $240K *
Shape the future of supply chain technology by leading engineering teams in optimizing platforms for logistics and order management. Drive innovation and efficiency while managing a diverse team of ex...
2 days ago
$120K - $145K *
Lead the charge in product strategy and execution for Driver and Rider applications, ensuring a seamless user experience across mobile and web platforms while collaborating closely with engineering an...
2 weeks ago
Internal Communications Manager
$88K - $147K *
Inspire and elevate employee engagement through strategic internal communications. Collaborate with leaders to craft and deliver impactful messaging that drives understanding of company goals and fost...
Reposted 2 weeks ago
Director of Product Management, Early Childhood & Public Sector Solutions
$110K - $140K *
Drive product innovation by leading the development of AI-enabled solutions for public sector agencies, enhancing early childhood systems through strategic vision, technical architecture, and customer...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.