Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Capture & Business Development Manager
$85K - $110K *
Drive business growth by identifying and qualifying federal procurement opportunities, focusing on healthcare contracts. Collaborate on capture strategies and build partnerships to enhance win probabi...
2 days ago
Vice President, Engineering, EPM
$212K - $265K *
Drive transformative software engineering across EPM products, lead modernization, build innovative SaaS capabilities, and enhance operational excellence in a high-impact role overseeing global teams...
3 weeks ago
$104K - $155K *
Lead the charge in customer-focused project management, ensuring effective delivery of technical solutions while coordinating with diverse stakeholders and fostering strong relationships for successfu...
Reposted 2 days ago
Senior Director, Product Management, Agentic Platform
$192K - $303K *
Empower innovation as you lead the strategy and development of core platform primitives, driving the future of agentic systems and ensuring product teams can rapidly create and deploy advanced agents...
2 weeks ago
Senior Technical Program Manager
$115K - $275K *
Manage the delivery of GPU clusters for AI workloads by coordinating teams across engineering, networking, and operations. Develop strategies, manage risks, and ensure timely, quality launches to scal...
Reposted 3 days ago
Senior Implementation Project Manager
$110K - $130K *
Manage implementation projects, ensuring clear ownership and accountability across complex customer engagements while maintaining rigorous oversight of critical paths and deliverables for timely launc...
Reposted 3 weeks ago
Director, HCS Client Strategy & Product
$140K - $180K *
Unlock potential by leading client strategy and product initiatives, driving growth through market insights and cross-functional collaboration. Shape solutions that enhance client value and optimize H...
1 week ago
$180K - $200K *
Empower partner operations by leading strategy, optimizing processes, and enhancing tools for a diverse global partner ecosystem. Collaborate cross-functionally to ensure scalable infrastructure and m...
1 week ago
Director, Procurement & Vendor Management
$150K - $186K *
Transform procurement strategies by leading vendor management and building strategic partnerships. Drive operational efficiency while optimizing spend and enhancing supplier performance to support lon...
2 weeks ago
$100K - $120K *
Execute comprehensive program management for a critical Air Force contract, leading a diverse team to ensure compliance, quality, and performance across multiple global operations while maintaining 24...
3 days ago
Organizational Change Management (OCM) Senior Consultant
$115K - $135K *
Join a team that's transforming Medicaid agencies through expert OCM strategies. Leverage your project management and change management skills to enhance health outcomes and build stronger communities...
Today
Senior Analyst of Transformation
$95K - $115K *
Join a team that's driving transformative change through strategic analysis and execution. This high-visibility role collaborates with leadership to ensure progress on critical initiatives and enhance...
Reposted 1 week ago
$145K - $175K *
Join a team that's redefining AI-driven solutions by leading product development for an innovative tech concierge. Drive the evolution of agent capabilities, ensuring quality and reliability while col...
5 days ago
$150K - $180K *
Optimize engagement and monetization strategies for an AI-driven product, transforming customer interactions into measurable growth. Lead cross-functional teams to innovate and implement effective use...
5 days ago
$217K - $298K *
Lead the charge in shaping Root's platform and AI engineering strategy, overseeing critical infrastructure and driving operational excellence across teams to deliver intelligent products at scale...
Reposted 4 days ago
Director of Finance - Ancillary Services
$100K - $115K *
Transform your career by leading financial strategy and operations for innovative service lines. Collaborate with senior leaders to enhance profitability, oversee budgeting, and drive growth initiativ...
1 week ago
Global Strategic Partnership Director
$150K - $180K *
Transform global partner strategies to drive revenue and market share through innovative go-to-market models, collaborating with key stakeholders to establish impactful partnerships and optimize sales...
4 days ago
$125K - $169K *
Lead the charge in enhancing customer success initiatives by driving engagement, optimizing processes, and fostering strong relationships. Collaborate with cross-functional teams to ensure exceptional...
Reposted 3 weeks ago
Program Director, Professional Services
$180K - $200K *
Accelerate progress at regional Professional Services by leading teams, driving growth and quality in consulting engagements while fostering strategic partnerships and developing innovative service of...
Reposted 1 week ago
Principal Engineer, Transformation Engineering
$131K - $196K *
Unlock potential by developing AI-driven applications and data pipelines. Collaborate with teams to enhance operational efficiency through innovative technical solutions, ensuring quality and scalabil...
2 days ago
$150K - $180K *
Transform enterprise risk management by leading critical audits and enhancing controls. Maintain relationships with external auditors and foster compliance initiatives to mitigate risk across all oper...
Reposted 2 weeks ago
Director, Learning & Growth (Remote)
$132K - $232K *
Redefine career mobility strategies by integrating talent marketplace capabilities, enabling associates to explore growth opportunities through data-informed solutions and collaborative practices acro...
2 days ago
Principal, AI Transformation Lead
$154K - $193K *
Drive AI transformation by building client relationships, leading engagements, and delivering results. Own the sales process from prospecting to execution, ensuring successful integration of AI soluti...
Reposted 1 week ago
Chief of Staff, Digital & Product
$161K - $242K *
Join a team that's driving strategic initiatives and digital transformation. Collaborate with senior leaders to tackle complex challenges, influence decision-making, and ensure successful execution of...
1 week ago
Director of Insurance Plan Management
$120K - $150K *
Transform the landscape of dental negotiations by leading strategic partnerships with payers, optimizing contracts, and driving revenue growth through data-driven insights and collaborative execution...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.