Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$180K - $215K *
Transform corporate engagement by leading a high-performing team to integrate nature into business strategies, driving impactful outcomes for conservation and sustainability across diverse sectors and...
2 weeks ago
Director, Process & Operations Management, Medical and Scientific Affairs (MSA)
$150K - $258K *
Elevate your career by leading strategic initiatives in Medical and Scientific Affairs. Drive portfolio governance, enhance operational excellence, and foster cross-functional collaboration to deliver...
1 week ago
Director, Digital Product Management
$150K - $180K *
Empower the future of AI-driven digital products by leading strategy, portfolio management, and cross-functional collaboration to enhance user experiences and drive measurable business impact across d...
3 days ago
Technical Program Manager (TPM)
$115K - $145K *
Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...
1 week ago
Senior Project Manager, Campaign Operations
$180K - $200K *
Manage the campaign calendar and ensure timely launches by transforming customer requests into actionable specs. Collaborate with cross-functional teams to maintain project alignment and drive success...
1 week ago
$122K - $177K *
Unlock potential by leading HRIS strategy and optimization, overseeing a team to enhance Workday and UKG systems. Drive transformation and collaboration across HR, Finance, and Operations for impactfu...
4 days ago
21GRAMS- Senior Project Manager
$110K - $115K *
Join a team that's redefining healthcare project management. Lead integrated initiatives, mentor talent, and drive excellence across diverse campaigns while fostering collaboration and innovation in a...
Yesterday
Product Manager, Growth & Lifecycle
$110K - $130K *
Take ownership of customer-facing products that enhance user journeys. Drive growth through experimentation and data analysis, maximizing conversion and retention while partnering with cross-functiona...
3 weeks ago
$148K - $193K *
Join a dynamic team as a Program Manager, leading complex projects from inception to completion. Collaborate with diverse stakeholders, manage resources, and drive innovation while ensuring client sat...
1 week ago
Project Manager - Engineering Design
$95K - $115K *
Lead the charge in managing complex multi-disciplinary projects across diverse sectors, ensuring alignment with client goals and project scope from initiation to closeout. Foster collaboration and ove...
3 weeks ago
Vice President of Product and Technology PMO
$247K - $321K *
Accelerate progress at a high-growth SaaS organization by leading the Product & Technology PMO, driving execution excellence across R&D initiatives and fostering strategic alignment to scale operation...
Reposted 3 weeks ago
$127K - $203K *
Join the charge in shaping technical solutions by transforming stakeholder needs into actionable requirements, fostering collaboration within teams, and ensuring project success throughout the product...
Reposted 2 weeks ago
$114K - $128K *
Lead the charge in AI-augmented product delivery, ensuring quality and flow across initiatives. Collaborate with cross-functional teams to manage project milestones and facilitate decision-making in a...
3 days ago
Manager - Software Development Engineering S 4D
$80K - $100K *
Unlock potential by leading a dynamic team of developers to deliver high-quality software solutions, collaborating with stakeholders, and driving strategic project initiatives while fostering a cultur...
4 days ago
Senior Project Manager - Engineering Design
$110K - $130K *
Lead the delivery of complex projects across multifaceted industries by managing teams, budgets, and schedules while ensuring quality, safety, and client satisfaction in regulated environments...
3 weeks ago
$90K - $108K *
Drive successful project execution by managing customer projects from quotation to completion. Collaborate with teams and stakeholders to ensure timely delivery, quality standards, and customer satisf...
2 days ago
Senior Project Manager - U.S. Healthcare Programs
$110K - $130K *
Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...
Reposted 3 weeks ago
$175K - $215K *
Pioneer your career by leading financial planning and analysis, driving strategic initiatives, and guiding cross-functional collaboration to impact organizational success at a high level of decision-m...
3 weeks ago
Project Director, Virtual Services
$85K - $105K *
Transform virtual resettlement services by leading a national portfolio that enhances access for refugees. Oversee strategy, implementation, and compliance while fostering partnerships and innovative...
3 days ago
$225K - $275K *
Lead the charge in redefining Total Rewards strategy, enhancing compensation, equity, and benefits to attract and retain top talent while anticipating workforce shifts driven by AI and market trends...
Reposted 3 weeks ago
$235K - $294K *
Lead and mentor a high-performing design team, driving product design strategy and delivering user-centric solutions. Collaborate with stakeholders to enhance customer experiences and foster a culture...
3 weeks ago
Senior Manager, Support Operations
$125K - $140K *
Help us scale and enhance support operations in telehealth by leading managers, optimizing workflows, and integrating technology to improve customer experience while maintaining quality and compliance...
4 weeks ago
$182K - $198K *
Build and lead a robust Service Management Office to enhance IT operations, ensuring effective governance, accountability, and continuous improvement across a complex 24x7 environment, while fostering...
1 week ago
Senior Director of Product Management Aurora Platform
$160K - $200K *
Join a dynamic team to define and drive the product strategy of an enterprise SaaS platform. Lead product managers, collaborate with engineering, and ensure platform coherence while enhancing client e...
1 month ago
Senior Project Manager - SYGMA- US
$108K - $180K *
Execute complex, cross-functional projects that align with strategic objectives. Collaborate with stakeholders and teams to ensure timely delivery, budget adherence, and successful outcomes while driv...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.