Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$150K - $180K *
Lead the charge in driving strategic growth by managing a high-performing sales team, refining sales strategies, and fostering a culture of excellence to achieve ambitious revenue goals...
6 days ago
Program Manager, Onsite Data Collection
$110K - $130K *
Explore the dynamic role of a Program Manager, overseeing end-to-end data collection programs. Drive operational excellence, client satisfaction, and strategic execution in a fast-paced environment, e...
3 days ago
$111K - $150K *
Transform product strategy and execution by leveraging data insights, leading cross-functional teams, and prioritizing customer needs to drive product success and business growth in a dynamic environm...
2 weeks ago
Product Management Senior Advisor
$113K - $188K *
Champion the development of innovative tools for customer service teams, enhancing agent efficiency and service quality. Collaborate across departments to drive product strategy, leveraging data and u...
Yesterday
Senior Director, Client Operations
$192K - $266K *
Drive best-in-class travel support through strategic leadership and operational excellence. Oversee lodging, flights, and customer advocacy, fostering a culture of continuous improvement and exception...
Reposted 6 days ago
Senior MEP Construction Manager I
$120K - $144K *
Advance large-scale mission-critical projects from design to completion. As a seasoned leader, oversee cross-functional teams, manage budgets, schedules, and ensure quality and safety standards while...
Reposted 1 month ago
$80K - $95K *
Advance cross-functional project management efforts by leading strategic initiatives that drive business objectives and enhance care programs while ensuring timely delivery and stakeholder alignment...
Reposted 3 weeks ago
$100K - $120K *
Shape the future of project management by leading software implementations, enhancing efficiency, and collaborating with diverse teams. Drive success through strategic planning and effective communica...
2 weeks ago
$160K - $235K *
Pioneer impactful change as you lead structured management initiatives, engaging clients with strategies that enhance technology and process adoption, while leveraging strong analytical skills and fos...
Reposted 3 weeks ago
Principal Delivery Manager, Portfolio
$145K - $188K *
Elevate delivery excellence by shaping strategies for Portfolio Management, ensuring seamless execution across teams while adapting to evolving technologies and processes. Lead the charge in establish...
2 weeks ago
$178K - $245K *
Drive end-to-end digital transformation for enterprise supply chains, managing high-stake programs while leading cross-functional teams. Ensure delivery excellence, foster client relationships, and op...
3 weeks ago
Senior Project Manager Product
$110K - $130K *
Shape the future of product development by leading cross-functional teams to deliver innovative solutions from concept to launch, ensuring alignment with business goals and quality standards...
1 week ago
Group Project Manager, Healthcare and Pharmaceutical Advertising
$120K - $150K *
Lead complex project management initiatives across multiple channels in the pharmaceutical advertising sector. Oversee cross-functional teams, ensuring timely delivery within budget while mentoring ju...
2 days ago
$170K - $185K *
Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...
Yesterday
$83K - $155K *
Contribute to the success of hygienic sensors by owning product strategy, collaborating with engineering, and driving market insights into actionable requirements. Lead product launches and manage lif...
3 days ago
$101K - $139K *
Drive impactful projects by leading cross-functional teams to ensure timely, on-budget delivery. Engage with stakeholders to enhance strategic planning and process improvement, contributing to major o...
Today
Account Director, Promotional Medical Education
$100K - $120K *
Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...
Reposted 1 week ago
$180K - $270K *
Shape the future of product management by leading strategic direction for key initiatives, driving execution through cross-functional collaboration, and optimizing outcomes via data-driven insights to...
4 weeks ago
Senior Director, Data Architecture
$150K - $180K *
Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...
1 week ago
Director, Software Engineering
$150K - $180K *
Innovate by leading software engineering excellence and AI adoption; manage cross-functional teams to develop impactful tech solutions while maintaining hands-on involvement with proof-of-concept proj...
4 weeks ago
$110K - $130K *
Engage your expertise to lead complex HL7 integrations across healthcare systems, enhancing interoperability and data-sharing capabilities. Collaborate with stakeholders to ensure successful implement...
3 weeks ago
$110K - $130K *
Optimize our product suite to elevate financial advisory capabilities through innovative AI solutions. Lead the entire product lifecycle, collaborating with diverse teams to transform complex workflow...
Reposted 4 weeks ago
Hybrid: Construction Project Manager
$100K - $110K *
Lead complex construction projects, ensuring compliance and timely delivery while managing multiple stakeholders and technical challenges. Foster relationships with contractors and government represen...
3 weeks ago
$100K - $150K *
Lead the charge in managing complex, technically sophisticated projects, focusing on data centers. Collaborate with diverse stakeholders to ensure project alignment with client goals, budgets, and sch...
Yesterday
$195K - $230K *
Drive growth by leading go-to-market strategies for TMC partnerships, building and executing plans from the ground up. Collaborate cross-functionally to influence product development and represent the...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.