Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$125K - $150K *

Unlock your potential by leading the development of innovative DRGV services, enhancing billing and coding optimization. Collaborate across teams to create scalable solutions that drive operational ex...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$198K - $233K *

Lead the charge in developing a robust content management system to enhance cross-functional workflows and publishing capabilities, fostering a high-performing engineering team dedicated to scalabilit...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $160K *

Drive the future of structural engineering by leading complex capital projects, mentoring junior staff, and ensuring technical excellence across diverse markets, particularly in healthcare. Collaborat...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$141K - $208K *

Drive procurement excellence by leading a team focused on process governance, system enhancements, and innovative solutions for contingent workforce management, ensuring efficiency and collaboration a...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Transportation

$180K - $220K *

Lead the integration of complex defense solutions by translating tactical requirements into innovative products. Collaborate with cross-functional teams to optimize performance and drive market adopti...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$86K - $99K *

Champion aggressive sales growth by building strategic relationships and generating leads in the insurance housing sector. Drive market share expansion through effective communication and innovative s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$88K - $105K *

Champion the negotiation and management of clinical trial agreements, ensuring compliance with standards while collaborating with stakeholders to facilitate timely study start-up and budget management...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Transform client relationships by leading customer success strategies, driving utilization, and maximizing retention across enterprise health systems. Oversee a high-performing team to ensure client s...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Lead the charge in defining and executing security architecture strategies, focusing on identity, access, and Zero Trust initiatives. Collaborate across teams to enhance security posture while enablin...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$277K - $350K *

Elevate your career by leading global demand generation strategies, driving enterprise pipeline growth, and optimizing high-impact ABM programs. Collaborate with cross-functional teams to innovate and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$149K - $248K *

Lead the transformation of Workday Financial Management, ensuring effective design and implementation across finance and enterprise processes. Collaborate with cross-functional teams to optimize ERP c...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Business Services

$152K - $173K *

Lead the transformation of identity lifecycle management by optimizing IAM processes, ensuring seamless integration with cloud-native solutions, and driving strategic initiatives that enhance security...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$201K - $251K *

Shape the future of global oncology marketing by leading brand strategy and execution for a groundbreaking pancreatic cancer treatment, collaborating with cross-functional teams to ensure successful m...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$178K - $261K *

Lead the charge in shaping a secure and seamless identity experience for millions globally. Drive strategy for authentication, account management, and recovery while collaborating across teams to prot...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Champion a transformative product vision, leading cross-functional teams to drive strategic outcomes in a dynamic digital health environment. Shape the future of patient care and client experience whi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $185K *

Join a team that's redefining the SaaS landscape by driving strategic growth and closing high-value deals. Engage with senior leaders, develop a robust pipeline, and collaborate cross-functionally to...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Media

$170K - $190K *

Drive the successful delivery of AI-enabled health IT projects by coordinating teams, managing schedules, and ensuring integration into clinical workflows. Collaborate with stakeholders to achieve mea...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$74K - $137K *

Drive client success by managing service delivery and support engagements, ensuring satisfaction and adherence to service level agreements while fostering strong relationships and optimizing operation...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Media

$150K - $180K *

Shape the future of governance by building and managing comprehensive GRC frameworks, ensuring regulatory compliance, policy library development, and strategic vendor risk management, while collaborat...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Transform creative operations by leading production processes and workflows. Oversee the entire creative lifecycle, ensuring timely delivery and high-quality output while enhancing collaboration acros...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$138K - $173K *

Drive cross-functional collaboration to ensure high-quality software delivery. Lead and mentor a team of engineers while optimizing processes and fostering a culture of innovation and continuous impro...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Transform product operations by enhancing collaboration across teams and streamlining the launch processes. Utilize data-driven insights and AI to identify bottlenecks and drive efficiency, ensuring s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Drive successful housing projects from inception to completion, ensuring adherence to design, budget, and schedule. Collaborate with clients and teams to enhance commercial housing expertise and expan...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$164K - $205K *

Elevate scientific rigor in real-world evidence development. Collaborate with cross-functional teams to ensure agent conceptualization and evaluation meet scientific standards, driving impactful solut...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $170K *

Champion the future of customer engagement by leading lifecycle marketing strategies. Drive retention and loyalty through data-driven personalization across multiple channels, maximizing customer life...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.