Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Project Leadership (Clinical Trials) - Homebased
$110K - $130K *
Champion global clinical trials by leading project teams to deliver excellence on time and within budget, ensuring high-quality outcomes that exceed client expectations in the biotech and pharma secto...
2 weeks ago
Principal, Security Operations
$120K - $145K *
Engage in advanced security operations as a Senior Security Analyst, leading incident response, enhancing detection capabilities, and driving process improvements to protect critical assets in a dynam...
Reposted 6 days ago
Director, Acquisitions & Transactions
$150K - $180K *
Lead multifamily transactions from sourcing to closing, ensuring disciplined execution and strategic alignment across teams. Drive outcomes through strong negotiation, relationship management, and a r...
2 weeks ago
$108K - $130K *
Drive the end-to-end release process for enterprise software, ensuring predictable, compliant, and low-risk deployments. Collaborate with cross-functional teams to manage risks, approvals, and communi...
1 week ago
$110K - $130K *
Join a team that's central to coordinating complex enterprise software releases across multiple platforms. You'll lead the release process, ensuring predictability and compliance while collaborating w...
1 week ago
$87K - $120K *
Champion business process excellence by bridging stakeholders and IT teams, driving Salesforce solutions, and optimizing workflows to enhance operational efficiency and user experience across the orga...
2 weeks ago
Forward Deployed Consultant, Manufacturing
$125K - $150K *
Drive AI transformations in manufacturing by collaborating with C-level executives to identify high-impact opportunities, build tailored solutions, and achieve measurable results in core operating pro...
Reposted 3 days ago
Principal Software Engineer, Agentic Data Platform
$255K - $290K *
Drive the technical vision for a complex database platform, ensuring scalability and performance. Lead architecture decisions, mentor engineers, and collaborate across teams to enhance data infrastruc...
3 weeks ago
$165K - $210K *
Drive innovation as you lead a data science team focused on generative AI and machine learning. Shape scalable solutions that address business challenges, leveraging advanced analytics to deliver meas...
4 weeks ago
$116K - $160K *
Accelerate progress at driving strategic initiatives within Operations and Member Experience. Collaborate with cross-functional teams to deliver impactful solutions, enhance operational efficiency, an...
2 weeks ago
Manager, Software Engineering (Resilience Engineering)
$204K - $290K *
Manage the Resilience Engineering team to enhance system reliability through production load testing and chaos engineering while fostering a proactive safety culture across engineering practices...
Reposted 1 week ago
Digital Forensics Engagement Manager
$100K - $120K *
Champion digital forensics projects by managing workflows, budgets, and client expectations. Collaborate with teams to enhance service delivery, ensuring high client satisfaction and adherence to dead...
3 days ago
Associate Scientific Director, Medical Communications
$110K - $140K *
Unlock potential by translating complex scientific data into clear, impactful communication. Collaborate across teams to shape strategy and elevate medical communications that enhance patient outcomes...
Reposted 1 week ago
Senior Advisor, Product Line Management, Maintenance & Managed Services
$176K - $281K *
Join a team that's shaping the future of service portfolios by driving strategic initiatives, enhancing customer outcomes, and optimizing financial performance across complex managed services and tech...
Today
Principal Enterprise Architect
$160K - $190K *
Join a team that's driving architectural excellence and AI adoption. You'll optimize cloud systems, enhance data processing, and lead engineering teams to innovate and scale efficiently, ensuring robu...
Reposted yesterday
$100K - $120K *
Collaborate to drive large-scale business initiatives, enhancing processes and stakeholder engagement. Analyze data and workflows to implement effective strategies, ensuring compliance and operational...
Reposted 6 days ago
Technical Product Manager, Data Platform
$120K - $145K *
Transform the data platform by owning product direction and delivery. Collaborate across teams to prioritize needs, streamline processes, and ensure engineering focuses on impactful projects while enh...
3 weeks ago
$80K - $95K *
Empower your career by leading engineering projects, coordinating teams, and enhancing technical expertise while ensuring compliance with safety standards and managing project performance effectively...
3 weeks ago
$135K - $160K *
Unlock potential by shaping mobile development solutions and guiding implementation teams to deliver projects following your architectural designs, ensuring quality and effectiveness throughout the de...
Reposted today
Program Manager, Commercial Solutions
$135K - $160K *
Innovate and manage large-scale commercial programs, driving cross-functional alignment and revenue growth. Lead end-to-end program development, ensuring operational excellence and strategic execution...
2 weeks ago
Director, Supply Chain Strategy & Excellence
$235K - $270K *
Join a dynamic team to lead transformative improvements in global supply chain operations, focusing on logistics excellence and strategic initiatives that enhance service, cost efficiency, and operati...
Reposted 1 week ago
Senior Strategic Program Manager, Data Center and AI
$132K - $165K *
Accelerate progress at multi-site data center and AI programs valued over $25M. Lead diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive c...
1 month ago
Sr. Director, Digital Pricing Strategy
$140K - $210K *
Shape innovative pricing strategies for a SaaS-first model, driving growth and alignment across teams. Lead transformation initiatives post-acquisition, ensuring competitive positioning and scalable m...
Today
$100K - $125K *
Empower project success by coordinating resources and stakeholders to deliver on time and within scope. Drive effective communication and risk management while ensuring alignment and achieving project...
Reposted 4 days ago
Director, CMS & HHS Business Development
$182K - $250K *
Champion market development strategies to enhance our presence in CMS and HHS. Leverage your expertise to build relationships, identify opportunities, and drive impactful outcomes in federal health IT...
Reposted 3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.