Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $120K *

Transform data into actionable insights by leading analytics solutions that drive decision-making and improve performance. Collaborate across functions to establish trusted metrics and promote self-se...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$147K - $211K *

Empower business leaders by driving strategic initiatives that enhance performance across Sales and Account Management. Utilize data-driven insights to translate complex challenges into actionable pla...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$294K - $443K *

Lead the development and execution of a global operational risk management strategy, ensuring alignment with business objectives and regulatory requirements while fostering a strong risk culture acros...

3 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $232K *

Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$156K - $202K *

Elevate patient experiences by leading strategic initiatives in governance, intelligence, and hospitality excellence. Drive performance improvement and operational consistency across healthcare servic...

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$95K - $193K *

Lead integrated commercial technology strategy execution across multiple initiatives, ensuring alignment of priorities, governance, and cross-functional collaboration to enhance value realization and...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$210K - $302K *

Execute strategic sales initiatives for Critical Environments, leading a dynamic team to exceed revenue goals, foster customer relationships, and expand market presence across North America in high-st...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Drive strategic growth by supporting project teams in budgeting, estimating, and scheduling throughout the preconstruction process, ensuring accuracy and efficiency in all phases of project delivery...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$165K - $190K *

Lead the charge in shaping financial strategy and operations, overseeing accounting, financial planning, and analysis. Drive integration across revenue models while managing a skilled finance team to...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$150K - $180K *

Shape the future of billing operations by leading a team to enhance accuracy, timeliness, and efficiency. Drive process improvements, manage complex accounts, and collaborate across functions to resol...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$96K - $207K *

Drive your career forward by leading the documentation and funding processes for complex lease transactions. Oversee a dynamic team, ensuring compliance and accuracy while collaborating closely with s...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$173K - $200K *

Elevate rebate product strategy by leading development, driving growth, and enhancing operational performance. Collaborate across teams to ensure compliance and deliver measurable outcomes that align...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$275K - $325K *

Join a team that's redefining financing products through innovative engineering. Lead complex initiatives, modernize systems, and leverage AI tools to enhance software development while ensuring data...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$119K - $186K *

Lead transformative process improvements by leveraging customer insights to enhance operational excellence across Health Systems & Government Services, ensuring scalable, customer-centered execution a...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$199K - $269K *

Grow your career with a leadership role in AI Digital Product Management, driving strategy and innovation across a portfolio of AI products. Collaborate with cross-functional teams to deliver scalable...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $250K *

Help us build a high-performing infrastructure team that drives operational excellence and reliability. Lead a diverse group of engineers, manage budgets, and modernize technology while collaborating...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$225K - $265K *

Shape the future of secure administration by leading a dynamic engineering team focused on backend services, user access, and account management. Drive innovation while ensuring operational excellence...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $110K *

Transform creative visions into reality by leading design projects, mentoring teams, and collaborating with clients. Drive strategic branding initiatives while ensuring high-quality deliverables in a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$180K - $225K *

Lead the architectural strategy and engineering evolution of Salesforce, managing a high-performing team while ensuring scalability, reliability, and security in revenue systems. Drive innovative solu...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$120K - $150K *

Transform subscription retention strategies to drive growth and revenue. Own metrics, analyze data, and collaborate cross-functionally to enhance customer experience and optimize retention initiatives...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$240K - $300K *

Lead the financial reporting and accounting policy functions, ensuring accurate GAAP and SEC compliance. Collaborate with cross-functional teams to enhance reporting processes and maintain robust inte...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Drive procurement excellence by managing vendor networks and asset supply chains for remote work solutions. Collaborate across teams to ensure scalable, compliant, and efficient deployment strategies...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $115K *

Unlock potential by leading workforce development initiatives that align education with labor market needs. Drive partnerships, secure funding, and advocate for students while ensuring compliance and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K - $220K *

Empower the future of financial operations by mastering money movement, ensuring seamless transactions and transparency. Collaborate with cross-functional teams to drive product success and enhance cl...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.