Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$221K - $368K *

Join a team that's dedicated to advancing oncology through leadership and collaboration. Drive strategic initiatives, mentor a high-performing team, and ensure compliance while fostering a culture of...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Lead the strategic operations of a centralized litigation docketing team, optimizing processes and technology to ensure accurate, consistent service across jurisdictions while mentoring staff and enha...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$136K - $214K *

Lead the charge in optimizing revenue operations by managing a dynamic team, enhancing forecasting processes, and ensuring data integrity across systems. Collaborate closely with sales leadership to d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive impactful preconstruction processes, delivering competitive bids and fostering client relationships. Lead project teams, enhance profitability, and promote a collaborative culture while ensuring...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$213K - $243K *

Champion the development of a robust commercial data strategy, ensuring high-quality, AI-ready data solutions that drive impactful decision-making and enhance commercial performance across the organiz...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $180K *

Create impactful strategies that connect business goals to technology solutions. Collaborate across teams to manage a comprehensive Martech roadmap, ensuring alignment and measurable growth through an...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Media

$101K - $174K *

Elevate your career by joining a dynamic team to design, deploy, and optimize a secure cloud-native platform. Collaborate across functions to enhance delivery pipelines and ensure reliability in a fas...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$92K - $158K *

Join a team that's dedicated to enhancing a secure PaaS for federal applications. You'll troubleshoot complex issues, support tenant operations, and collaborate on platform improvements, ensuring reli...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Champion process engineering excellence in petfood and meat production. Lead design projects, collaborate across teams, and ensure safe, innovative solutions that support client goals. Ideal for entre...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$116K - $181K *

Tackle the challenges of pricing management by leading a dynamic team in developing competitive cost proposals, ensuring compliance with regulations, and driving profitability through strategic analys...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$200K - $300K *

Analyze and execute complex tax and preferred equity transactions in renewable energy. Lead underwriting, model development, and investment analysis while mentoring team members and driving projects f...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $167K *

Join a team that's redefining growth operations by architecting systems and workflows that drive our go-to-market engine. Lead initiatives, collaborate across functions, and innovate with data to enha...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $90K *

Shape the future of production operations by leading a dynamic team to ensure safety, efficiency, and quality. Drive continuous improvement while managing schedules, performance, and compliance in a f...

4 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$80K - $95K *

Drive innovative HVAC procurement strategies, collaborating with teams to ensure optimal performance, budget adherence, and timely delivery of mechanical systems while fostering strong supplier relati...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$144K - $210K *

Drive compliance excellence by leading a team focused on identifying and addressing control gaps and violations across financial services, ensuring adherence to regulatory standards while enhancing su...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $150K *

Innovate your career with a strategic role focused on omnichannel marketing. Lead data-driven insights and creative recommendations for a top financial services brand, collaborating across teams to en...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $238K *

Build and scale the Partner Operations function, turning complexity into leverage by designing systems and processes that enhance partnerships and align with revenue goals for measurable impact and st...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Join a team that's driving excellence in production planning and scheduling. Lead a dedicated group to optimize manufacturing processes, enhance operational efficiency, and ensure customer satisfactio...

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Unlock potential by leading Health and VA claims operations, driving strategic initiatives, enhancing recovery outcomes, and ensuring operational excellence across multiple teams and client portfolios...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $169K *

Transform customer outcomes by leading a high-performing team dedicated to leveraging Samsara's solutions. Drive strategic growth while ensuring enterprise clients realize sustained value from their i...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$76K - $148K *

Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $140K *

Pioneer GxP compliance in digital quality management, ensuring software and AI products meet regulatory standards. Collaborate with stakeholders to enhance quality processes and support audits, drivin...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$315K - $370K *

Join a team that's redefining offensive security by leading engineering efforts to transform research into scalable, customer-facing products. Drive strategy, execution, and innovation across multiple...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Join our team to drive growth by reactivating lapsed accounts and expanding our advertising measurement solutions across various sectors. This sales-focused role combines prospecting and program manag...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.