Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$78K - $95K *

Help us support project management in commercial and mission-critical environments. Collaborate with teams to ensure compliance, facilitate communication, and assist in project coordination, all while...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Technical Services

$176K - $281K *

Empower your career by leading complex service portfolios, driving strategic initiatives, and delivering measurable value through innovative solutions in a dynamic environment. Collaborate across team...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$200K - $220K *

Lead successful outcomes across complex technology programs and large-scale customer environments. Drive governance, manage risks, and facilitate executive relationships while coordinating multiple cr...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Information Technology

$187K - $257K *

Elevate global sales operations by leading forecasting, pipeline management, and productivity initiatives. Collaborate with sales leaders to enhance clarity and consistency, driving growth through inn...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$145K - $190K *

Unlock your potential by leading transformative Oracle Cloud Procurement initiatives in healthcare. Engage with clients, mentor teams, and drive impactful solutions while enhancing operational efficie...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$170K - $210K *

Drive the end-to-end Order-to-Cash function, enhancing processes and leading a high-performing team to optimize revenue operations, billing, and collections while partnering with key departments for s...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by leading the RPA strategy and AI integration across banking platforms. Drive automation architecture, development, and deployment while mentoring teams and ensuring compliance in a...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$70K - $150K *

Develop strategic business relationships to drive revenue growth and enhance customer satisfaction. Utilize market insights to create tailored business plans and ensure profitable account management w...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$236K - $312K *

Join a team that's shaping the future of AAA game production. Lead cross-functional efforts, mentor senior managers, and define strategies to ensure high-quality, narrative-driven experiences across o...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Media

$190K - $296K *

Advance strategic partnerships by engaging with top tech companies, driving growth through innovative collaborations. Lead negotiations from inception to launch, ensuring impactful results for family...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in optimizing operational activities within the DHMS program, ensuring compliance and driving continuous improvement. Collaborate with stakeholders to implement effective strategies an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $205K *

Join a team that's driving M&A success by leading financial strategy, target evaluation, and integration planning. Collaborate with senior leaders to identify opportunities and execute critical phases...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Develop and execute innovative product strategies for a global Oil-Flooded compressor portfolio, driving profitable growth through customer insights and cross-functional collaboration to enhance marke...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$145K - $160K *

Accelerate product development by managing the software lifecycle, collaborating with cross-functional teams, and driving strategic initiatives to enhance user experience and meet stakeholder needs...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $190K *

Lead the charge in managing the software development lifecycle for innovative products, leveraging low-code platforms to enhance user experience and drive strategic initiatives across cross-functional...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$128K - $160K *

Drive operational excellence and customer satisfaction by managing services teams, optimizing project delivery, and enhancing client engagement strategies for government clients, ensuring alignment wi...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Lead strategic initiatives by coordinating cross-functional teams to drive major partner launches and product developments, ensuring alignment with executive priorities and measurable outcomes for com...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$135K - $160K *

Transform product security by leading strategy, conducting threat modeling, and collaborating across teams to ensure secure design and compliance. Drive innovation in security practices while mentorin...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Champion the execution of a comprehensive compensation strategy across a multi-site organization, ensuring alignment with business goals and operational efficiency while overseeing payroll accuracy an...

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the charge in operationalizing a comprehensive compensation philosophy across a multi-site organization, ensuring effective execution of annual cycles, internal equity, and payroll oversight whil...

Maryland Heights, MORemote

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$134K - $157K *

Empower a creative team to bring innovative design concepts to life while mentoring junior talent and collaborating with clients. Lead presentations and manage multiple projects, ensuring strategic in...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$200K - $270K *

Lead the development and execution of GxP quality systems, ensuring compliance and oversight for clinical and CMC quality. Drive vendor qualification, audits, and training while fostering a culture of...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead and innovate partner marketing strategies across diverse retail segments, managing a team to drive growth and enhance relationships. Collaborate cross-functionally to develop impactful campaigns...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$228K - $285K *

Transform the design landscape by leading a talented team to elevate visual and interaction quality in financial software. Drive innovation, simplify complex workflows, and inspire designers to delive...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$93K - $166K *

Drive transformation initiatives by leading complex projects, collaborating with stakeholders, and implementing strategic recommendations to enhance operational excellence and achieve impactful result...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.