Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Manager - APR DRG Concept Development Analyst
$100K - $125K *
Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...
2 weeks ago
$110K - $130K *
Elevate global post-market surveillance by leading a team focused on safety, compliance, and performance of medical devices. Drive field actions, analyze data, and collaborate cross-functionally to en...
2 weeks ago
$198K - $233K *
Shape AI product strategy by synthesizing trends, customer needs, and tech capabilities. Collaborate with engineering and design to drive innovation, enabling AI solutions that deliver genuine custome...
2 weeks ago
Customer Project Manager, Imaging Systems/Construction (Seattle / Western Washington)
$92K - $147K *
Drive successful customer installation projects in the Seattle area, ensuring quality and timely execution through expert coordination and technical expertise while fostering strong relationships with...
1 week ago
Director, PB Coding Operations & Education
$122K - $177K *
Lead coding operations and education initiatives to ensure compliance, accuracy, and optimal reimbursement across the organization. Manage staff training and oversee coding standards while collaborati...
2 weeks ago
VP, Technology and Strategy (Job 1513)
$230K - $285K *
Champion technology strategy and innovation across Health and Defense sectors. Lead enterprise technology direction, drive execution of solutions, and establish strategic partnerships to enhance compe...
Reposted yesterday
$135K - $160K *
Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...
3 weeks ago
Project Engineer - Solar and Storage
$95K - $115K *
Lead solar resource assessments and performance analytics for utility-scale projects. Engage with clients, optimize energy yield, and enhance methodologies while ensuring operational excellence in sol...
4 days ago
$150K - $180K *
Unlock potential by leading multidisciplinary engineering teams to design and deploy complex power generation systems. Drive strategic initiatives, ensure technical excellence, and foster collaboratio...
3 days ago
Global Program Operations Manager
$80K - $110K *
Shape the future of operational excellence by partnering with leadership to enhance program standards, drive performance metrics, and foster cross-regional alignment in a dynamic environment focused o...
Today
Senior Director, Clinical Operations
$270K - $280K *
Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...
3 weeks ago
Director, North American B2B Secular Shift – Property & Casualty Insurance
$150K - $180K *
Drive growth in the Property & Casualty Insurance sector by spearheading innovative B2B payment strategies. Collaborate across teams to forge partnerships, enhance solutions, and lead transformative c...
Reposted 1 week ago
Product Owner - Professional Coding
$110K - $130K *
Transform product vision into reality by leading the Encoder solution, managing backlogs, and collaborating with stakeholders to maximize value and user satisfaction. Drive strategic decisions and ens...
1 month ago
Geotechnical Senior Project Manager
$100K - $120K *
Empower your career by leading geotechnical projects, ensuring quality, mentoring teams, and driving business development while fostering a positive workplace culture and community engagement...
3 weeks ago
Senior Director, Marketing (Global Home Care Division)
$150K - $180K *
Unlock potential by driving Brand P&L through strategic leadership and marketing execution across the Home and Garden division, achieving ambitious sales, GM, and EBITDA goals through integrated omnic...
Reposted 2 days ago
Director, Advisor Solutions Group
$90K - $100K *
Join a team that's dedicated to driving client success through strategic sales initiatives, relationship management, and innovative investment solutions, while fostering growth and collaboration withi...
Today
Senior Director, Innovation and Delivery
$200K - $250K *
Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...
Reposted 4 days ago
$109K - $183K *
Join a team that's driving innovation in product operations. You'll manage program initiatives, streamline processes, and enhance portfolio reporting while collaborating with cross-functional teams to...
3 weeks ago
Director, RevOps Strategy & Operations
$150K - $180K *
Drive operational excellence by leading revenue operations strategy, optimizing processes, and enhancing cross-functional alignment to support scalable growth and measurable outcomes in a dynamic envi...
4 days ago
Senior Manager, Customer Success
$110K - $130K *
Lead a dynamic team to enhance customer success, drive retention, and maximize revenue growth. Shape strategies and workflows while collaborating cross-functionally to deliver exceptional value and ou...
1 week ago
BAS / Controls Assistant Project Manager
$78K - $95K *
Help us support project management in commercial and mission-critical environments. Collaborate with teams to ensure compliance, facilitate communication, and assist in project coordination, all while...
Yesterday
Senior Advisor, Product Line Management, Implementation Services
$176K - $281K *
Empower your career by leading complex service portfolios, driving strategic initiatives, and delivering measurable value through innovative solutions in a dynamic environment. Collaborate across team...
3 days ago
Sr. Technical Delivery Manager - Infrastructure/Data Center (General)
$200K - $220K *
Lead successful outcomes across complex technology programs and large-scale customer environments. Drive governance, manage risks, and facilitate executive relationships while coordinating multiple cr...
Reposted yesterday
Director, Global Field Sales Operations
$187K - $257K *
Elevate global sales operations by leading forecasting, pipeline management, and productivity initiatives. Collaborate with sales leaders to enhance clarity and consistency, driving growth through inn...
3 weeks ago
Digital Consulting Senior Manager, Oracle Cloud SCM
$145K - $190K *
Unlock your potential by leading transformative Oracle Cloud Procurement initiatives in healthcare. Engage with clients, mentor teams, and drive impactful solutions while enhancing operational efficie...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.