Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Development Manager, Site Selection & Predevelopment
$95K - $115K *
Optimize site selection and entitlement strategies for data center projects, evaluating land opportunities and coordinating with utilities. Drive feasibility assessments and maintain project schedules...
Reposted today
$100K - $120K *
Transform your career by leading onsite commissioning activities for advanced data center projects. Drive coordination across teams, ensuring quality and timely deployment of BMS/EPMS systems in a fas...
4 days ago
Executive Director, Translational Medicine & Pediatric Planning
$246K - $332K *
Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...
3 weeks ago
Integrated Logistics Support Manager
$93K - $125K *
Lead the charge in managing integrated logistics efforts across military programs, guiding a team of specialists in delivering projects on schedule and within budget while ensuring regulatory complian...
Reposted 1 week ago
$230K - $290K *
Advance your career by leading procurement strategies that drive efficiency and value creation. Collaborate cross-functionally to optimize processes and foster a culture of operational excellence whil...
1 week ago
Project Management Senior Consultant
$110K - $130K *
Transform initiatives through expert project management, elevating communication and cross-team coordination to ensure operational excellence and drive strategic goals...
Reposted 3 days ago
Project Management Senior Consultant
$100K - $120K *
Drive impactful projects forward, align stakeholders, and enhance operational efficiency. Collaborate across teams to manage priorities and deliver precise communications in a fast-paced environment...
Reposted 3 days ago
$81K - $100K *
Deliver exceptional client service by managing strategic accounts, driving retention, and fostering growth. Collaborate with cross-functional teams to address customer needs and expand business opport...
4 weeks ago
Manager of Clinical Engagement
$115K - $130K *
Join a team that's redefining clinical engagement by leading strategic initiatives to enhance clinician pipelines, improve hiring processes, and foster partnerships across multiple regions, driving or...
Reposted 5 days ago
$264K - $296K *
Empower the CEO by translating strategic priorities into actionable outcomes, fostering alignment across the Executive Leadership Team, and ensuring efficient decision-making to enhance organizational...
Yesterday
Director, Engineering- North America
$140K - $218K *
Transform the future of aerospace engineering by leading multi-site teams, enhancing technical capabilities, and driving operational excellence to meet customer demands and improve performance across...
3 weeks ago
Specialist Manager, Procurement and Category Management
$93K - $155K *
Grow your career with a dynamic role in Federal contract administration, managing high-value subcontracts, advising teams, and driving strategic negotiations to enhance revenue and retention while ens...
1 week ago
Specialist Manager, Procurement and Category Management
$93K - $155K *
Transform contract administration by advising teams on Federal regulations, managing high-value subcontracts, and driving strategic negotiations to enhance revenue and retention. Collaborate with stak...
1 week ago
Product Manager - Clinical Member Data
$86K - $138K *
Lead the charge in defining product vision and strategy, aligning stakeholders, and overseeing execution. Collaborate across teams to prioritize clinical data assets, ensuring maximum business value a...
3 weeks ago
Program Manager, Operations Process
$110K - $130K *
Join a dynamic team to enhance operational workflows for autonomous trucking. Lead process design, maintain quality standards, and drive continuous improvement across multiple workstreams while collab...
3 days ago
$114K - $165K *
Join our dynamic team to lead the development of high-performance backend solutions. Leverage your expertise in Java, microservices, and real-time data streaming to drive innovation and mentor a talen...
Reposted 4 days ago
Strategic Business Developer - Key Projects
$120K - $160K *
Join a dynamic team to drive strategic business development for large-scale construction projects, leveraging existing relationships and market insights to create long-term value and influence decisio...
Yesterday
Commissioning Project Coordinator
$110K - $144K *
Lead the charge in coordinating on-site commissioning activities, ensuring alignment among stakeholders and successful project delivery. This senior role requires strong technical expertise and leader...
1 week ago
$224K - $431K *
Empower innovation by leading a team of engineers to enhance AI infrastructure, ensuring reliability and performance for cutting-edge research. Shape the platform's future while collaborating with div...
3 days ago
Principal Technical Program Manager, Data Centers
$102K - $209K *
Transform data center operations by leading end-to-end capacity delivery programs. Collaborate with diverse teams to ensure timely project execution, quality assurance, and stakeholder engagement, dri...
3 weeks ago
$112K - $135K *
Transform platform reliability by leading incident management and operational resilience efforts across critical wealth management systems, ensuring effective communication and governance during high...
2 days ago
Deputy Director, Partnerships & Technical Integration
$196K - $210K *
Partner with us to shape the future of semiconductor workforce development by aligning industry needs with educational strategies, fostering partnerships, and leading initiatives that ensure technical...
Reposted today
Manager, CAM Business Operations Lead
$54K - $159K *
Lead the charge in integrating CAM capabilities across diverse business lines. Collaborate with cross-functional teams to ensure effective implementation and operational success, driving alignment on...
Yesterday
Principal Business Intelligence Lead, System Performance
$200K - $275K *
Elevate data strategy and reporting for the System Performance Organization, transforming complex robotics data into compelling narratives for executive stakeholders while fostering team growth and al...
Reposted 2 weeks ago
$120K - $140K *
Drive procurement excellence by leading a strategic Grounds S&P team. Collaborate with senior stakeholders to enhance sourcing, optimize performance, and mentor top talent, all while crafting innovati...
Reposted 2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.