Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$95K - $115K *

Optimize site selection and entitlement strategies for data center projects, evaluating land opportunities and coordinating with utilities. Drive feasibility assessments and maintain project schedules...

Reposted today

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Transform your career by leading onsite commissioning activities for advanced data center projects. Drive coordination across teams, ensuring quality and timely deployment of BMS/EPMS systems in a fas...

4 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$246K - $332K *

Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$93K - $125K *

Lead the charge in managing integrated logistics efforts across military programs, guiding a team of specialists in delivering projects on schedule and within budget while ensuring regulatory complian...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$230K - $290K *

Advance your career by leading procurement strategies that drive efficiency and value creation. Collaborate cross-functionally to optimize processes and foster a culture of operational excellence whil...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Transform initiatives through expert project management, elevating communication and cross-team coordination to ensure operational excellence and drive strategic goals...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Drive impactful projects forward, align stakeholders, and enhance operational efficiency. Collaborate across teams to manage priorities and deliver precise communications in a fast-paced environment...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Business Services

$81K - $100K *

Deliver exceptional client service by managing strategic accounts, driving retention, and fostering growth. Collaborate with cross-functional teams to address customer needs and expand business opport...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$115K - $130K *

Join a team that's redefining clinical engagement by leading strategic initiatives to enhance clinician pipelines, improve hiring processes, and foster partnerships across multiple regions, driving or...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$264K - $296K *

Empower the CEO by translating strategic priorities into actionable outcomes, fostering alignment across the Executive Leadership Team, and ensuring efficient decision-making to enhance organizational...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $218K *

Transform the future of aerospace engineering by leading multi-site teams, enhancing technical capabilities, and driving operational excellence to meet customer demands and improve performance across...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$93K - $155K *

Grow your career with a dynamic role in Federal contract administration, managing high-value subcontracts, advising teams, and driving strategic negotiations to enhance revenue and retention while ens...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$93K - $155K *

Transform contract administration by advising teams on Federal regulations, managing high-value subcontracts, and driving strategic negotiations to enhance revenue and retention. Collaborate with stak...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$86K - $138K *

Lead the charge in defining product vision and strategy, aligning stakeholders, and overseeing execution. Collaborate across teams to prioritize clinical data assets, ensuring maximum business value a...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team to enhance operational workflows for autonomous trucking. Lead process design, maintain quality standards, and drive continuous improvement across multiple workstreams while collab...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$114K - $165K *

Join our dynamic team to lead the development of high-performance backend solutions. Leverage your expertise in Java, microservices, and real-time data streaming to drive innovation and mentor a talen...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $160K *

Join a dynamic team to drive strategic business development for large-scale construction projects, leveraging existing relationships and market insights to create long-term value and influence decisio...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $144K *

Lead the charge in coordinating on-site commissioning activities, ensuring alignment among stakeholders and successful project delivery. This senior role requires strong technical expertise and leader...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$224K - $431K *

Empower innovation by leading a team of engineers to enhance AI infrastructure, ensuring reliability and performance for cutting-edge research. Shape the platform's future while collaborating with div...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$102K - $209K *

Transform data center operations by leading end-to-end capacity delivery programs. Collaborate with diverse teams to ensure timely project execution, quality assurance, and stakeholder engagement, dri...

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$112K - $135K *

Transform platform reliability by leading incident management and operational resilience efforts across critical wealth management systems, ensuring effective communication and governance during high...

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$196K - $210K *

Partner with us to shape the future of semiconductor workforce development by aligning industry needs with educational strategies, fostering partnerships, and leading initiatives that ensure technical...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$54K - $159K *

Lead the charge in integrating CAM capabilities across diverse business lines. Collaborate with cross-functional teams to ensure effective implementation and operational success, driving alignment on...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $275K *

Elevate data strategy and reporting for the System Performance Organization, transforming complex robotics data into compelling narratives for executive stakeholders while fostering team growth and al...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$120K - $140K *

Drive procurement excellence by leading a strategic Grounds S&P team. Collaborate with senior stakeholders to enhance sourcing, optimize performance, and mentor top talent, all while crafting innovati...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.