Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$135K - $145K *

Lead the charge in strategic account management, driving growth and strengthening customer partnerships. Collaborate cross-functionally to align business objectives with customer needs while overseein...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$114K - $190K *

Drive project success as a Senior Project Controller, leading complex schedules and ensuring timely delivery across major infrastructure projects while collaborating with cross-functional teams to man...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Business Services

$110K - $200K *

Transform clinical research by leading operational oversight of studies, ensuring compliance with protocols and regulations. Collaborate with teams to drive site feasibility, manage budgets, and enhan...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $200K *

Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$188K - $235K *

Unlock potential by shaping and driving the People Systems roadmap, translating business needs into scalable processes, and managing technology vendors to enhance the employee lifecycle through innova...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$205K - $231K *

Champion the Athena member experience by leading cross-functional teams to enhance vulnerability management and remediation processes, ensuring a seamless workflow for enterprise customers in a fast-p...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a team that's shaping the future of utility-scale transmission projects. Oversee contractor activities, ensure quality installations, and foster strong relationships while managing project logist...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$90K - $96K *

Join a dynamic team to support program management and evaluation efforts, ensuring effective collaboration across departments. Contribute to monitoring, reporting, and learning activities that drive i...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$128K - $192K *

The Workday Financials/Professional Services Automation Senior Principal Consultant is a dynamic professional responsible for leading Workday Professional Services Automation and Financials workstream...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$205K - $256K *

Transform your career by leading Apollo's data strategy, ensuring the highest quality B2B data for GTM success. Drive product vision, collaborate cross-functionally, and enhance customer experiences t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $190K *

Empower nonprofit organizations to maximize their impact by leading product strategy and execution for innovative fundraising solutions. Drive growth through deep customer insights, collaborative part...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$127K - $243K *

Lead the charge in driving P&C product strategy and growth across the Northeast, leveraging data analytics and market insights to enhance profitability and market share while collaborating with stakeh...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $135K *

Lead the maintenance function at a large automated fulfillment center. Drive reliability and safety for all equipment and systems while overseeing a skilled team. Collaborate with departments to enhan...

Reposted today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$122K - $183K *

Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $225K *

Manage the valuation process for private equity investments, ensuring accuracy and compliance. Collaborate with investment teams and external providers while leading initiatives to enhance valuation p...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Champion the accounts payable process by leading a dynamic team, ensuring accuracy and efficiency from invoice receipt to payment. Collaborate across departments to enhance workflows and drive automat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $130K *

Champion quality and commissioning excellence across diverse construction projects, ensuring compliance and safety while fostering collaboration among teams and stakeholders to drive impactful results...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$146K - $224K *

Elevate clinical development by leading the strategy for biopharma platforms. Drive product lifecycles, collaborate with cross-functional teams, and ensure compliance while transforming workflows into...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$225K - $275K *

Lead the charge in transforming FP&A through automation and AI, enhancing financial insights and strategic partnerships across the organization. Drive efficient planning, forecasting, and reporting to...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$200K *

Lead the charge in driving enterprise growth marketing strategies, optimizing pipeline performance, and orchestrating cross-functional initiatives to scale demand generation and revenue outcomes acros...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $145K *

Elevate your career by managing complex IT programs from inception to completion. Lead teams, oversee budgets, and drive business development while ensuring technical performance and customer satisfac...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Lead the charge in organizational change management for complex life sciences transformations, focusing on global Veeva CRM implementations. Drive strategy, execution, and stakeholder engagement acros...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$119K - $142K *

Join a team that's redefining digital operations by leading strategic initiatives, enhancing customer experiences, and driving growth in a fast-paced environment. Shape the future of MODAL Digital whi...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$77K - $135K *

Join us to manage a diverse portfolio of 90-120 real estate assets, ensuring lease compliance and fostering strong landlord relationships while solving complex challenges across North America...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.