Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$116K - $210K *
Join a dynamic team to lead complex IT program delivery, ensuring operational excellence and stakeholder engagement while managing resources, budgets, and schedules across multiple workstreams in a fa...
Today
Senior Product Manager, International Platform and Globalization
$137K - $186K *
Unlock potential by leading cross-functional teams to deliver platform features that enhance global market capabilities. Drive localization efforts and ensure seamless integration across diverse regio...
2 days ago
Director, Analyst, Workday Contract Negotiations & Licensing
$148K - $175K *
Unlock your potential as a Director, leveraging insights and expertise to guide clients in navigating complex SaaS negotiations and market trends, while driving impactful strategies that enhance busin...
3 weeks ago
Sr. Practice Manager -- AI Agentic Ops
$150K - $190K *
Help us shape the future of AI operations by leading a dynamic team focused on innovative solutions, strategic partnerships, and technical excellence in agentic environments. Drive growth and operatio...
2 weeks ago
Product Manager, Ignite Member Operations
$125K - $141K *
Lead the product direction for membership operations, balancing customer needs and enterprise requirements. Collaborate with teams to enhance workflows, improve operational outcomes, and ensure a seam...
1 week ago
Program Manager (Data Center Hardware)
$145K - $155K *
Transform customer engagements by leading a dynamic team, ensuring project success through effective management and operational oversight. Drive continuous improvement and enhance client satisfaction...
4 days ago
Transaction Management Director
$150K - $190K *
Pioneer innovative strategies in commercial real estate transaction management, leading a dynamic team to negotiate leases and optimize client outcomes while driving operational excellence and fosteri...
Reposted yesterday
$110K - $130K *
Lead the charge in managing retail construction projects, ensuring timely delivery and adherence to brand standards. Collaborate with design and operations teams to create engaging consumer environmen...
Yesterday
$139K - $250K *
Lead the charge in driving strategic product development for a diverse insurance portfolio, collaborating with stakeholders to enhance performance and achieve revenue targets throughout the product li...
3 weeks ago
Senior Manager, Security Engineering & Operations
$160K - $200K *
Lead and shape a high-performing Security Engineering and Operations team, driving proactive threat management and strategic engineering initiatives across North America while enhancing operational ef...
1 week ago
Engineering Manager, Governance & Access
$150K - $180K *
Empower our team to build innovative security and governance solutions, shaping access management for both human and agent users. Lead a small, dynamic group as we define architectural foundations and...
4 weeks ago
$80K - $95K *
Drive quality assurance excellence by leading the development of scalable processes that enhance student recruitment and enrollment, ensuring compliance and continuous improvement across all interacti...
2 weeks ago
Technical Product Manager - Salesforce CRM Platform
$120K - $145K *
Transform the Salesforce CRM platform by driving strategy, enhancements, and adoption, while leading cross-functional collaboration to deliver user-centric solutions that elevate customer engagement a...
Reposted 2 days ago
Manager, Infrastructure Governance
$125K - $178K *
Accelerate progress at the forefront of cloud security governance, leading a dynamic team to enhance compliance, drive automation, and ensure robust risk management across multi-cloud environments...
1 week ago
$220K - $250K *
Drive the product roadmap for Unify Release Orchestration, enhancing developer experience while coordinating releases across multiple services, engaging customers, and leading initiatives for AI-nativ...
Reposted yesterday
Associate Director of Operations
$110K - $130K *
Drive operational excellence across multiple facilities, ensuring compliance and efficiency. Lead Plant Managers and teams to optimize manufacturing processes, implement continuous improvement initiat...
4 weeks ago
Proposals and Contract Manager
$95K - $115K *
Join a team that's driving impactful proposal and contract management, collaborating across functions to deliver compelling client materials and support clinical research initiatives with a focus on a...
Reposted yesterday
$160K - $210K *
Join a dynamic team to shape financial systems that drive growth and innovation. You'll own the strategy for money movement and banking, collaborating across departments to enhance reliability and sca...
Reposted 4 days ago
Project Mgr, Strategic Initiatives
$80K - $95K *
Lead cross-functional projects in health plan relations, enhancing revenue cycle performance and outcomes. Utilize strong communication and project management skills to coordinate initiatives, track p...
Reposted 1 week ago
Senior Engagement Principal | Software Delivery
$212K - $222K *
Champion client success as you lead Aera solution deployments, building trusted relationships with executives to drive value and Decision Intelligence roadmaps while managing project delivery and fost...
Reposted 6 days ago
Principal AI Transformation Consultant
$136K - $160K *
Drive transformation by partnering with architecture and engineering firms to enhance workflows through AI-enabled solutions. Collaborate with stakeholders to redefine processes, ensuring operational...
1 week ago
Executive Director, Manufacturing
$175K - $210K *
Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...
1 week ago
Senior Manager, Workforce Management
$110K - $130K *
Grow your expertise in workforce management by building and optimizing systems that enhance operational efficiency and member experience. Lead cross-functional initiatives to ensure staffing aligns wi...
5 days ago
Procurement and Expediting Manager - Lake City Microgrid and CHP
$95K - $115K *
Optimize procurement processes and vendor management for industrial projects. Collaborate with teams to ensure timely delivery of equipment and materials, while maintaining compliance with safety and...
2 weeks ago
VP, Finance Excellence and Transformation
$255K - $295K *
Optimize finance transformation strategies by leading enterprise-wide initiatives that unify processes, systems, and governance in a rapidly growing organization, enabling scalability and supporting l...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.