Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$116K - $210K *

Join a dynamic team to lead complex IT program delivery, ensuring operational excellence and stakeholder engagement while managing resources, budgets, and schedules across multiple workstreams in a fa...

RemoteRemote

Today

  •   11 - 15 years exp.  •   Technical Services

$137K - $186K *

Unlock potential by leading cross-functional teams to deliver platform features that enhance global market capabilities. Drive localization efforts and ensure seamless integration across diverse regio...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$148K - $175K *

Unlock your potential as a Director, leveraging insights and expertise to guide clients in navigating complex SaaS negotiations and market trends, while driving impactful strategies that enhance busin...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$150K - $190K *

Help us shape the future of AI operations by leading a dynamic team focused on innovative solutions, strategic partnerships, and technical excellence in agentic environments. Drive growth and operatio...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $141K *

Lead the product direction for membership operations, balancing customer needs and enterprise requirements. Collaborate with teams to enhance workflows, improve operational outcomes, and ensure a seam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$145K - $155K *

Transform customer engagements by leading a dynamic team, ensuring project success through effective management and operational oversight. Drive continuous improvement and enhance client satisfaction...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $190K *

Pioneer innovative strategies in commercial real estate transaction management, leading a dynamic team to negotiate leases and optimize client outcomes while driving operational excellence and fosteri...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in managing retail construction projects, ensuring timely delivery and adherence to brand standards. Collaborate with design and operations teams to create engaging consumer environmen...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$139K - $250K *

Lead the charge in driving strategic product development for a diverse insurance portfolio, collaborating with stakeholders to enhance performance and achieve revenue targets throughout the product li...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Lead and shape a high-performing Security Engineering and Operations team, driving proactive threat management and strategic engineering initiatives across North America while enhancing operational ef...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Media

$150K - $180K *

Empower our team to build innovative security and governance solutions, shaping access management for both human and agent users. Lead a small, dynamic group as we define architectural foundations and...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Drive quality assurance excellence by leading the development of scalable processes that enhance student recruitment and enrollment, ensuring compliance and continuous improvement across all interacti...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Transform the Salesforce CRM platform by driving strategy, enhancements, and adoption, while leading cross-functional collaboration to deliver user-centric solutions that elevate customer engagement a...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $178K *

Accelerate progress at the forefront of cloud security governance, leading a dynamic team to enhance compliance, drive automation, and ensure robust risk management across multi-cloud environments...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$220K - $250K *

Drive the product roadmap for Unify Release Orchestration, enhancing developer experience while coordinating releases across multiple services, engaging customers, and leading initiatives for AI-nativ...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Drive operational excellence across multiple facilities, ensuring compliance and efficiency. Lead Plant Managers and teams to optimize manufacturing processes, implement continuous improvement initiat...

4 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$95K - $115K *

Join a team that's driving impactful proposal and contract management, collaborating across functions to deliver compelling client materials and support clinical research initiatives with a focus on a...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $210K *

Join a dynamic team to shape financial systems that drive growth and innovation. You'll own the strategy for money movement and banking, collaborating across departments to enhance reliability and sca...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Lead cross-functional projects in health plan relations, enhancing revenue cycle performance and outcomes. Utilize strong communication and project management skills to coordinate initiatives, track p...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$212K - $222K *

Champion client success as you lead Aera solution deployments, building trusted relationships with executives to drive value and Decision Intelligence roadmaps while managing project delivery and fost...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Information Technology

$136K - $160K *

Drive transformation by partnering with architecture and engineering firms to enhance workflows through AI-enabled solutions. Collaborate with stakeholders to redefine processes, ensuring operational...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Grow your expertise in workforce management by building and optimizing systems that enhance operational efficiency and member experience. Lead cross-functional initiatives to ensure staffing aligns wi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Optimize procurement processes and vendor management for industrial projects. Collaborate with teams to ensure timely delivery of equipment and materials, while maintaining compliance with safety and...

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$255K - $295K *

Optimize finance transformation strategies by leading enterprise-wide initiatives that unify processes, systems, and governance in a rapidly growing organization, enabling scalability and supporting l...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.