Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$165K - $248K *

Lead enterprise-scale operations for cloud services, ensuring performance and customer satisfaction. Drive a multidisciplinary team, manage service transitions, and leverage data-driven metrics to enh...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$124K - $156K *

Shape the future of AI Services by owning product strategy and execution. Collaborate with engineering teams to define agentic capabilities, drive tool strategies, and establish AI quality standards t...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Elevate preconstruction processes by leading project planning, coordination, and execution. Collaborate with stakeholders to ensure alignment on scope, budget, and timelines while managing cost estima...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$123K - $217K *

Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Execute high-value construction projects, leading renovations and new builds. Oversee multiple projects while collaborating closely with stakeholders to ensure successful delivery and compliance with...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Shape the future of pricing strategy by leading deal governance and commercial frameworks. Collaborate across teams to enhance pricing effectiveness and support ARR growth while guiding complex deal s...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Drive successful industrial construction projects by leading planning, execution, and safety management. Leverage your expertise to ensure quality, cost control, and client satisfaction across multipl...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$123K - $145K *

Optimize product launches by collaborating cross-functionally to ensure timely delivery and high quality. Leverage engineering expertise to manage complex programs, drive continuous improvement, and e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$142K - $196K *

Join a team that's redefining global transfer pricing strategies. Lead compliance, governance, and advisory efforts while collaborating with cross-functional leaders to enhance operational efficiency...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Healthcare

$135K - $160K *

Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$146K - $189K *

Partner with us to enhance our community health provider network. Leverage your expertise in provider relations and network management to drive growth, improve access to care, and support our mission...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$123K - $164K *

Drive end-to-end design execution for major data center projects, leading multidisciplinary teams to ensure alignment with safety, sustainability, and commercial goals throughout the project lifecycle...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$95K - $115K *

Contribute to large-scale projects by leading steel procurement logistics, ensuring timely delivery and quality verification. Collaborate with project teams to resolve issues and mentor junior enginee...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$140K - $165K *

Join a team that's redefining healthcare technology by owning the product roadmap, translating company goals into actionable tasks, and ensuring seamless delivery of AI-driven solutions that enhance p...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Take ownership of facilities management operations, ensuring optimal performance and compliance. Lead a diverse team, manage budgets, and enhance service quality while fostering strong relationships w...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Shape quality standards by leading design and construction oversight, ensuring compliance and continuous improvement across all project phases while mentoring teams and collaborating with stakeholders...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $105K *

Shape the future of talent acquisition by leading a dynamic team, driving innovative recruiting strategies, and partnering with executive leadership to enhance organizational growth and performance in...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$136K - $160K *

Optimize account-based marketing strategies to drive engagement and sales for new products. Lead end-to-end campaign execution, asset production, and pipeline accountability while collaborating closel...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$116K - $167K *

Lead the successful delivery of complex projects, managing resources and stakeholders while ensuring adherence to budget, schedule, and quality standards. Empower teams through mentorship and expert g...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$151K - $199K *

Empower sales teams by designing and delivering innovative training programs that enhance product knowledge and sales techniques, ensuring alignment with marketing strategies and industry trends to dr...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $176K *

Help us redefine clinical development narratives by leading cross-functional teams to create compelling, strategic stories that enhance customer engagement and drive successful bid defenses, ultimatel...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in monitoring transactional risk for banking and treasury services, ensuring effective fraud detection and credit risk management across multiple program layers while driving resolutio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$76K - $130K *

Join a team that's driving change by leading stakeholder engagement and adoption of Agile practices and Atlassian tools. This role blends communication strategy and organizational change management to...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Accelerate fundraising efforts by managing a diverse portfolio of major gift prospects, cultivating relationships, and securing transformative donations to support a national mission focused on ending...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Empower customer success as a Senior Strategic Program Manager, overseeing major contracts, driving growth strategies, and enhancing operational efficiency. Collaborate with teams to ensure excellence...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.