Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Program Manager, AI Enablement
$190K - $210K *
Lead the charge in strategic AI initiatives, coordinating cross-functional teams to drive program success. Utilize your program management expertise to align priorities, manage risks, and enhance AI c...
3 weeks ago
$72K - $115K *
Transform the future of digital products by managing their lifecycle, optimizing user experiences, and collaborating with cross-functional teams to drive engagement and adoption while ensuring alignme...
1 week ago
Managing Supervisor, Health Communications
$71K - $125K *
Champion healthcare communications by leading global PR initiatives, managing client relationships, and driving impactful campaigns that engage diverse stakeholders in the pharmaceutical sector, parti...
Reposted 1 week ago
$65K - $116K *
Drive exceptional client experiences by leading delivery operations, managing relationships, and leveraging analytics to identify service gaps. Collaborate cross-functionally to ensure seamless execut...
1 week ago
Appian Forward Deployed Product Owner
$148K - $247K *
Join a team that's driving digital transformation in financial services. Leverage your expertise in Appian to design and optimize workflows, collaborate with stakeholders, and enhance client-centric s...
4 weeks ago
Project Executive - Mission Critical Construction
$150K - $180K *
Lead the charge in managing large-scale data center projects, ensuring profitability, client satisfaction, and team performance while overseeing safety, quality, and risk management throughout the pro...
4 days ago
Manager, Third-Party Risk Management (TPRM)
$164K - $241K *
Lead a global TPRM program, enhancing vendor security risk management through AI-driven workflows and assessments. Manage a team, ensure compliance, and drive risk decisions while collaborating with c...
Reposted 2 days ago
SAP Project Manager/ Scrum Master
$85K - $124K *
Champion innovative project management solutions, guiding teams through configuration, product demonstrations, and stakeholder collaboration to deliver value-driven consulting services that adapt to e...
1 week ago
SAP Project Manager/ Scrum Master
$86K - $124K *
Champion project success by leading SAP implementations, managing teams, and ensuring alignment with client needs. Drive agile methodologies, facilitate collaboration, and deliver innovative solutions...
2 weeks ago
Electrical OFCI Design Manager - Data Center Construction
$170K - $210K *
Lead the design management of owner-furnished electrical equipment for a hyperscale data center, ensuring integration, compliance, and quality standards while guiding teams and managing client communi...
4 days ago
1723 - Senior Manager, Strategic Sourcing- D&C
$97K - $190K *
Champion strategic sourcing in Design & Construction, leading procurement initiatives to optimize value and drive cost savings. Collaborate with stakeholders to enhance supplier relationships and ensu...
3 weeks ago
$95K - $115K *
Transform product strategies by leading the launch and lifecycle management of innovative solutions. Collaborate cross-functionally to identify market opportunities and enhance user efficiency through...
2 weeks ago
$150K - $180K *
Transform security operations by leading strategic initiatives, managing incident responses, and guiding a skilled team. Drive technical direction and ensure robust security measures across M&A, testi...
Yesterday
$80K - $95K *
Drive the execution of large-scale field operations, ensuring projects meet budget, schedule, and safety standards while mentoring team members and fostering strong relationships with clients and part...
Reposted 1 week ago
$180K - $220K *
Engage with cross-functional leaders to elevate product strategy and execution. Drive innovation in product development, leveraging AI to enhance customer value and business performance across a diver...
2 weeks ago
$78K - $110K *
Unlock potential by leading resource management initiatives to optimize workforce capacity, align talent with project needs, and drive operational excellence. Collaborate with teams to ensure timely s...
4 days ago
Director, People Strategy & Optimization
$165K - $175K *
Champion strategic people initiatives by advising leadership, crafting executive communications, and leveraging analytics to drive organizational effectiveness and accountability across the People fun...
2 weeks ago
Sr Manager Product Context Engineering
$143K - $165K *
Lead the design and delivery of enterprise technology solutions, driving innovation and growth. Oversee product lifecycles, mentor teams, and collaborate with stakeholders to ensure high-quality, scal...
Reposted 3 days ago
$90K - $110K *
Drive IT operations excellence by leading a hands-on team, enhancing service delivery, and optimizing internal systems while actively engaging in technical troubleshooting and support...
4 weeks ago
Director, Sales Strategy & Operations - Groups
$170K - $230K *
Elevate the sales strategy and operations by partnering with leadership to enhance productivity, implement AI solutions, and drive data-driven decision-making. Lead a team to optimize processes and en...
3 weeks ago
$150K - $200K *
Elevate your career by leading HCP engagement and clinical marketing initiatives. Drive strategic insights and educational content for the HSCT portfolio, fostering impactful connections and enhancing...
1 week ago
$88K - $113K *
Transform proposal management by leading cross-functional teams to deliver high-quality, compliant responses. Drive efficiency through strategic planning, risk management, and collaboration, ensuring...
1 week ago
Software Engineering Manager, Billing
$150K - $180K *
Champion the evolution of our billing systems by leading a dynamic engineering team. Drive strategy, ensure accuracy, and collaborate across departments to enhance customer trust as we scale our usage...
2 weeks ago
Principal Cloud Operations Manager
$165K - $248K *
Lead enterprise-scale operations for cloud services, ensuring performance and customer satisfaction. Drive a multidisciplinary team, manage service transitions, and leverage data-driven metrics to enh...
Reposted 4 weeks ago
$124K - $156K *
Shape the future of AI Services by owning product strategy and execution. Collaborate with engineering teams to define agentic capabilities, drive tool strategies, and establish AI quality standards t...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.