Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$190K - $210K *

Lead the charge in strategic AI initiatives, coordinating cross-functional teams to drive program success. Utilize your program management expertise to align priorities, manage risks, and enhance AI c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$72K - $115K *

Transform the future of digital products by managing their lifecycle, optimizing user experiences, and collaborating with cross-functional teams to drive engagement and adoption while ensuring alignme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$71K - $125K *

Champion healthcare communications by leading global PR initiatives, managing client relationships, and driving impactful campaigns that engage diverse stakeholders in the pharmaceutical sector, parti...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Media

$65K - $116K *

Drive exceptional client experiences by leading delivery operations, managing relationships, and leveraging analytics to identify service gaps. Collaborate cross-functionally to ensure seamless execut...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$148K - $247K *

Join a team that's driving digital transformation in financial services. Leverage your expertise in Appian to design and optimize workflows, collaborate with stakeholders, and enhance client-centric s...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Lead the charge in managing large-scale data center projects, ensuring profitability, client satisfaction, and team performance while overseeing safety, quality, and risk management throughout the pro...

4 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$164K - $241K *

Lead a global TPRM program, enhancing vendor security risk management through AI-driven workflows and assessments. Manage a team, ensure compliance, and drive risk decisions while collaborating with c...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$85K - $124K *

Champion innovative project management solutions, guiding teams through configuration, product demonstrations, and stakeholder collaboration to deliver value-driven consulting services that adapt to e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$86K - $124K *

Champion project success by leading SAP implementations, managing teams, and ensuring alignment with client needs. Drive agile methodologies, facilitate collaboration, and deliver innovative solutions...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $210K *

Lead the design management of owner-furnished electrical equipment for a hyperscale data center, ensuring integration, compliance, and quality standards while guiding teams and managing client communi...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$97K - $190K *

Champion strategic sourcing in Design & Construction, leading procurement initiatives to optimize value and drive cost savings. Collaborate with stakeholders to enhance supplier relationships and ensu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Transform product strategies by leading the launch and lifecycle management of innovative solutions. Collaborate cross-functionally to identify market opportunities and enhance user efficiency through...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Transform security operations by leading strategic initiatives, managing incident responses, and guiding a skilled team. Drive technical direction and ensure robust security measures across M&A, testi...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Drive the execution of large-scale field operations, ensuring projects meet budget, schedule, and safety standards while mentoring team members and fostering strong relationships with clients and part...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $220K *

Engage with cross-functional leaders to elevate product strategy and execution. Drive innovation in product development, leveraging AI to enhance customer value and business performance across a diver...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$78K - $110K *

Unlock potential by leading resource management initiatives to optimize workforce capacity, align talent with project needs, and drive operational excellence. Collaborate with teams to ensure timely s...

4 days ago

  •   5 - 7 years exp.  •   Media

$165K - $175K *

Champion strategic people initiatives by advising leadership, crafting executive communications, and leveraging analytics to drive organizational effectiveness and accountability across the People fun...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $165K *

Lead the design and delivery of enterprise technology solutions, driving innovation and growth. Oversee product lifecycles, mentor teams, and collaborate with stakeholders to ensure high-quality, scal...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $110K *

Drive IT operations excellence by leading a hands-on team, enhancing service delivery, and optimizing internal systems while actively engaging in technical troubleshooting and support...

4 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$170K - $230K *

Elevate the sales strategy and operations by partnering with leadership to enhance productivity, implement AI solutions, and drive data-driven decision-making. Lead a team to optimize processes and en...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $200K *

Elevate your career by leading HCP engagement and clinical marketing initiatives. Drive strategic insights and educational content for the HSCT portfolio, fostering impactful connections and enhancing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $113K *

Transform proposal management by leading cross-functional teams to deliver high-quality, compliant responses. Drive efficiency through strategic planning, risk management, and collaboration, ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Champion the evolution of our billing systems by leading a dynamic engineering team. Drive strategy, ensure accuracy, and collaborate across departments to enhance customer trust as we scale our usage...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$165K - $248K *

Lead enterprise-scale operations for cloud services, ensuring performance and customer satisfaction. Drive a multidisciplinary team, manage service transitions, and leverage data-driven metrics to enh...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$124K - $156K *

Shape the future of AI Services by owning product strategy and execution. Collaborate with engineering teams to define agentic capabilities, drive tool strategies, and establish AI quality standards t...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.