Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$155K - $410K *

Accelerate progress at driving alliance strategy and sales enablement efforts, fostering executive relationships, and translating market insights into actionable solutions to support revenue growth an...

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$155K - $410K *

Transform alliance strategy and sales enablement for Microsoft Dynamics 365, driving revenue growth and client engagement. Lead cross-functional teams to align market insights with actionable sales pl...

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$125K - $150K *

Unlock growth by leading federal capture efforts, developing strategies, and securing contracts. Collaborate with cross-functional teams to align customer needs with capabilities, ensuring compliance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $200K *

Elevate operational excellence by leading transformation initiatives and optimizing Shared Services. Collaborate with senior leaders to drive measurable improvements in productivity, cost efficiency...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$190K - $240K *

Accelerate progress at strategic partnerships in the NAMER region by identifying, onboarding, and managing key partners. Drive revenue growth through collaboration, enablement, and relationship manage...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$137K - $220K *

Lead the charge in managing strategic customer relationships, driving revenue growth, and ensuring account health. Collaborate across teams to deliver innovative hydrogen solutions while navigating co...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

Transform financial planning by developing models, tracking expenses, and conducting analyses. Collaborate with FP&A teams to prepare cash flow projections and monthly reports, driving insights for en...

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Drive the execution of complex capital projects, ensuring safety, budget adherence, and regulatory compliance while collaborating with cross-functional teams to enhance operational efficiency and busi...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by leading integrated marketing programs that drive brand awareness and revenue growth. Collaborate with Sales and executive leadership to translate business goals into impactful m...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $245K *

Elevate your career by leading lifecycle marketing strategies that enhance customer engagement, retention, and monetization. Drive impactful programs while managing a high-performing team and collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$120K - $170K *

Contribute to seamless MEP project execution by managing construction, advocating for owners, and ensuring compliance with standards throughout design, installation, and commissioning phases on divers...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Launch impactful B2B events by developing strategies, managing budgets, and executing flawless experiences. Collaborate with marketing leaders to enhance brand presence and foster relationships throug...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Lead impactful planning and construction projects across multiple healthcare facilities. Drive successful outcomes through effective management, team leadership, and innovative problem-solving while e...

2 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$145K - $175K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them through complex stakeholder environments with predictive intelligence and data-driven insights to drive impactful...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$110K - $130K *

Lead the charge in transforming complex genomic data into compelling narratives that resonate with audiences, driving engagement across diverse channels while collaborating with cross-functional teams...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $225K *

Transform healthcare data into actionable insights by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercia...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$177K - $221K *

Lead the development and execution of global CMC regulatory strategies to support clinical trials and market applications, ensuring compliance with regulatory requirements throughout the product lifec...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform the internal IT landscape by managing employee support, systems administration, and infrastructure scalability. Drive automation and security initiatives while enhancing user experience in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$190K - $237K *

Optimize sourcing strategies and procurement processes for clinical operations, ensuring effective vendor management and governance across global clinical trials. Collaborate with cross-functional tea...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock your potential as a Customer Program Manager, driving strategic objectives and ensuring on-time delivery of high-quality products while fostering strong customer and supplier relationships in a...

4 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$168K - $285K *

Shape the future of financial strategy by leading R&D finance, partnering with executives to drive investment decisions, optimize spending, and enhance forecasting accuracy in a dynamic, AI-driven env...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $140K *

Join a team that's dedicated to designing and implementing resilient infrastructure solutions that enhance operational readiness and supportability while aligning with enterprise architecture standard...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $150K *

Lead financial strategy for M&A initiatives, driving capital deployment and presenting insights to the Board. Collaborate with cross-functional teams to optimize performance and ensure successful inte...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$184K - $200K *

Unlock potential by driving the vision and strategy for innovative products that empower independent candidates and enhance user engagement. Collaborate with cross-functional teams to create scalable...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.