Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Lead a dynamic team to enhance service delivery, drive employee development, and ensure high customer satisfaction while managing operational needs and fostering a positive organizational culture...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Shape the future of federal financial operations by driving user adoption and change management for a new tool. Collaborate with stakeholders to enhance user experience, streamline processes, and ensu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $180K *

Join a team that's dedicated to enhancing non-clinical product performance through data-driven insights. Lead KPI optimization and collaborate with stakeholders to improve user experiences across vari...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Transform project execution by leading on-site coordination, ensuring budget adherence, and fostering team development. Drive profitability and safety while managing subcontractors and optimizing sche...

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Lead the charge in managing complex construction projects, overseeing field operations, ensuring safety and quality, and mentoring junior staff while driving project performance from mobilization to c...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$181K - $225K *

Lead the charge in operationalizing complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development and manage global lab relationships, ensuring strategic...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$100K - $150K *

Shape impactful health initiatives by providing expert project management support to the CDC's Office of the Director, ensuring effective prioritization, coordination, and execution of programs in a d...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$170K - $243K *

Transform product innovation by leading AI-driven strategies and experiments, collaborating across teams to enhance software solutions and improve employee experiences in a dynamic, fast-paced environ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$107K - $159K *

Lead the charge in developing and implementing global compensation programs, ensuring alignment with business objectives and compliance. Collaborate with cross-functional teams to design innovative so...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $172K *

Unlock potential by leading product initiatives for 360e Facility Coding, collaborating with diverse teams to enhance customer experiences and drive business value through innovative solutions and eff...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$202K - $253K *

Drive the development of AI-driven coaching solutions, overseeing multiple squads from prototype to production. Ensure quality delivery, manage resources effectively, and foster team growth while main...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in managing and maintaining physical assets, ensuring safety and compliance while overseeing strategic planning and budget management for facility operations...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$127K - $175K *

Shape the future of data solutions as you lead the development of a unified data model, harmonizing diverse stakeholder needs into a cohesive strategy that enhances data operations and drives innovati...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Drive project success by leveraging technical expertise to lead multidisciplinary teams in delivering industrial and infrastructure projects, enhancing client relationships, and advancing your project...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Transform project delivery by leading multidisciplinary teams in industrial and infrastructure projects. Leverage your engineering expertise to enhance client relationships and drive project success a...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$202K - $346K *

Pioneer strategic growth and operational excellence in our OneStream consulting practice. Lead business development, enhance client relationships, and cultivate a high-performing team to deliver excep...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Legal & Accounting

$118K - $190K *

Lead the charge in delivering innovative solutions by managing complex technical projects. Collaborate with cross-functional teams to ensure successful implementation while promoting best practices an...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $185K *

Transform strategic sourcing for HR and Benefits, leading complex engagements and driving cost savings while ensuring high supplier performance and stakeholder satisfaction across diverse client needs...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$115K - $135K *

Lead mechanical engineering projects from scope to design, ensuring optimal performance and compliance with University standards. Collaborate with architects and engineers, shaping the future of campu...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$164K - $284K *

Lead and inspire a high-performing software engineering team, driving product innovation and technical excellence while fostering a culture of collaboration and continuous improvement in a fully remot...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$183K - $215K *

Shape the future of North American inland transportation by leading product strategy and development. Collaborate with cross-functional teams to deliver actionable insights and drive market success in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$158K - $237K *

Accelerate progress at the forefront of aerospace innovation by leading the B-2 program and Air Combat Systems portfolio, managing all phases from inception to completion while fostering customer rela...

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$158K - $237K *

Lead major aircraft repair efforts as a Program Manager, overseeing all phases from inception to completion. Manage resources, cultivate customer relationships, and ensure compliance while driving pro...

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$188K - $245K *

Drive innovative UX design strategies in clinical settings, leading a talented team to enhance decision support and care coordination. Collaborate across functions to integrate AI and elevate user exp...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.