Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$90K - $120K *

Manage the delivery of security engagements, ensuring alignment among clients, engineers, and internal teams. Oversee project timelines, documentation, and communication to deliver high-quality result...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Champion a team of product managers to drive innovative software solutions. Shape product direction, enhance customer understanding, and elevate product quality while fostering leadership and collabor...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Transform the future of product management by leading AI-driven initiatives, collaborating across teams, and shaping strategies that enhance customer experiences and drive business growth in a dynamic...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $105K *

Unlock potential by leading the development of innovative digital products. Collaborate with cross-functional teams to enhance client experiences, drive profitability, and ensure compliance in a dynam...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive regional growth initiatives by building referral partnerships and executing marketing strategies in the healthcare sector, focusing on long-term care and post-acute networks to enhance organizat...

Yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $115K *

Unlock potential in preconstruction management by leading mechanical system estimates for advanced manufacturing and mission-critical projects, collaborating with diverse teams to ensure accuracy and...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$155K - $160K *

Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $100K *

Advance community success by leading operations, ensuring compliance, and fostering a culture of excellence. Drive resident care, financial performance, and team development while building strong exte...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Shape the future of doctoral education by leading a dynamic program focused on strategic leadership and innovation. Drive curriculum quality, faculty engagement, and student success while ensuring com...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Elevate your career by leading a dynamic team in delivering innovative water resources projects. This role combines technical expertise, project management, and staff development to enhance client rel...

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Drive project success by managing contracts and changes for federal construction, ensuring compliance and timely documentation while collaborating with stakeholders to maintain project integrity and e...

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $160K *

Drive high-quality medical content development across multiple projects, ensuring strategic alignment and regulatory compliance. Collaborate with teams and clients to deliver compelling communications...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$225K - $265K *

Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$117K - $147K *

Empower multi-site data center and AI infrastructure programs valued at $25M+, leading diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$117K - $158K *

Manage and prioritize the ERP product backlog, translating business needs into actionable requirements. Collaborate with stakeholders to enhance operational effectiveness and drive continuous improvem...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$205K - $240K *

Elevate technology strategy and operations for North America's supply chain, leading engineering teams to optimize platforms and processes. Drive innovation in order management and logistics while ens...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Take ownership of large-scale mission-critical construction projects, ensuring safety, quality, and financial performance while cultivating client relationships and team development to drive organizat...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Transform project delivery by leading cross-functional teams to ensure timely execution of Public Safety product implementations, enhancing client satisfaction and operational efficiency through exper...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $185K *

Lead cross-functional teams to drive excellence in software development for a SaaS platform, ensuring timely delivery and high-quality outcomes while fostering a collaborative engineering culture. Inn...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$100K - $135K *

Lead the charge in quality assurance and control for a large-scale data center project. Collaborate with teams to ensure electrical installations meet safety and compliance standards throughout all co...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$158K - $213K *

Oversee day-to-day accounting and treasury operations, ensuring accuracy and compliance. Lead month-end close processes, refine internal controls, and develop a high-performing team while integrating...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Accelerate healthcare outcomes by leading the Enhanced Care Management program. Oversee operations, drive strategic initiatives, and collaborate with teams to enhance patient care while ensuring compl...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $175K *

Lead the charge in managing complex Medicare claims processing projects, ensuring seamless integration of Oracle EBS with external systems. Oversee a large team, maintain project schedules, and drive...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$70K - $150K *

Join a team that's dedicated to supporting disaster recovery efforts through federal funding programs. Collaborate with local governments and nonprofits to ensure compliance and effective project form...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$94K - $179K *

Lead the charge in managing complex projects from inception to completion, ensuring timely delivery and stakeholder satisfaction while guiding cross-functional teams through the project lifecycle...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.