Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$90K - $120K *
Manage the delivery of security engagements, ensuring alignment among clients, engineers, and internal teams. Oversee project timelines, documentation, and communication to deliver high-quality result...
1 week ago
$135K - $160K *
Champion a team of product managers to drive innovative software solutions. Shape product direction, enhance customer understanding, and elevate product quality while fostering leadership and collabor...
2 weeks ago
$110K - $130K *
Transform the future of product management by leading AI-driven initiatives, collaborating across teams, and shaping strategies that enhance customer experiences and drive business growth in a dynamic...
2 weeks ago
$88K - $105K *
Unlock potential by leading the development of innovative digital products. Collaborate with cross-functional teams to enhance client experiences, drive profitability, and ensure compliance in a dynam...
Yesterday
Regional Director of Business Development
$110K - $130K *
Drive regional growth initiatives by building referral partnerships and executing marketing strategies in the healthcare sector, focusing on long-term care and post-acute networks to enhance organizat...
Yesterday
Mechanical Preconstruction Manager
$95K - $115K *
Unlock potential in preconstruction management by leading mechanical system estimates for advanced manufacturing and mission-critical projects, collaborating with diverse teams to ensure accuracy and...
2 weeks ago
Senior Director, Order-to-Cash (O2C)
$155K - $160K *
Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...
1 week ago
$95K - $100K *
Advance community success by leading operations, ensuring compliance, and fostering a culture of excellence. Drive resident care, financial performance, and team development while building strong exte...
3 weeks ago
Program Director, Ph.D. in Strategic Leadership and Innovation
$100K - $120K *
Shape the future of doctoral education by leading a dynamic program focused on strategic leadership and innovation. Drive curriculum quality, faculty engagement, and student success while ensuring com...
2 weeks ago
Department Manager - Water Resources
$100K - $120K *
Elevate your career by leading a dynamic team in delivering innovative water resources projects. This role combines technical expertise, project management, and staff development to enhance client rel...
3 weeks ago
Contracts and Change Manager - Lake City Microgrid and CHP
$95K - $115K *
Drive project success by managing contracts and changes for federal construction, ensuring compliance and timely documentation while collaborating with stakeholders to maintain project integrity and e...
2 weeks ago
Director, Medical Writing - Market Access Promotional Agency
$120K - $160K *
Drive high-quality medical content development across multiple projects, ensuring strategic alignment and regulatory compliance. Collaborate with teams and clients to deliver compelling communications...
Today
$225K - $265K *
Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...
2 weeks ago
Program Manager, Data Center and AI
$117K - $147K *
Empower multi-site data center and AI infrastructure programs valued at $25M+, leading diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive...
1 week ago
$117K - $158K *
Manage and prioritize the ERP product backlog, translating business needs into actionable requirements. Collaborate with stakeholders to enhance operational effectiveness and drive continuous improvem...
1 week ago
Sr. Engineering Director, Supply Chain and Order Management Systems
$205K - $240K *
Elevate technology strategy and operations for North America's supply chain, leading engineering teams to optimize platforms and processes. Drive innovation in order management and logistics while ens...
Reposted 1 week ago
Mission Critical Project Executive - Construction
$125K - $150K *
Take ownership of large-scale mission-critical construction projects, ensuring safety, quality, and financial performance while cultivating client relationships and team development to drive organizat...
Reposted 3 weeks ago
Project Manager (Customer Facing) - Remote
$80K - $95K *
Transform project delivery by leading cross-functional teams to ensure timely execution of Public Safety product implementations, enhancing client satisfaction and operational efficiency through exper...
1 week ago
$150K - $185K *
Lead cross-functional teams to drive excellence in software development for a SaaS platform, ensuring timely delivery and high-quality outcomes while fostering a collaborative engineering culture. Inn...
Reposted 3 weeks ago
$100K - $135K *
Lead the charge in quality assurance and control for a large-scale data center project. Collaborate with teams to ensure electrical installations meet safety and compliance standards throughout all co...
3 weeks ago
$158K - $213K *
Oversee day-to-day accounting and treasury operations, ensuring accuracy and compliance. Lead month-end close processes, refine internal controls, and develop a high-performing team while integrating...
Reposted 2 weeks ago
Director, Enhanced Care Management
$110K - $130K *
Accelerate healthcare outcomes by leading the Enhanced Care Management program. Oversee operations, drive strategic initiatives, and collaborate with teams to enhance patient care while ensuring compl...
3 days ago
$130K - $175K *
Lead the charge in managing complex Medicare claims processing projects, ensuring seamless integration of Oracle EBS with external systems. Oversee a large team, maintain project schedules, and drive...
Today
FEMA PA Program Delivery Manager
$70K - $150K *
Join a team that's dedicated to supporting disaster recovery efforts through federal funding programs. Collaborate with local governments and nonprofits to ensure compliance and effective project form...
Reposted 1 week ago
$94K - $179K *
Lead the charge in managing complex projects from inception to completion, ensuring timely delivery and stakeholder satisfaction while guiding cross-functional teams through the project lifecycle...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.