Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$155K - $410K *

Drive impactful SAP Order to Cash initiatives, guiding client strategies and enhancing operational efficiency while mentoring teams and shaping business growth through innovative solutions and executi...

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$155K - $410K *

Drive client success by leading SAP Order to Cash initiatives, enhancing operational efficiency, and mentoring teams. Shape strategies, oversee engagements, and translate business needs into effective...

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$150K - $180K *

Join a dynamic team to lead the development of innovative Microsoft-based platforms, driving modernization and AI integration while ensuring robust, scalable, and secure solutions in a highly regulate...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Transform business workflows by leading the development of low-code AI products that enhance efficiency and deliver measurable outcomes. Collaborate with teams to identify needs, validate solutions, a...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $180K *

Elevate customer insights by translating data into actionable product capabilities. Collaborate with cross-functional teams to prioritize initiatives, enhance marketing performance, and leverage AI fo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Champion preconstruction initiatives for large-scale commercial projects, ensuring accurate estimates, client satisfaction, and alignment with company goals through effective communication and relatio...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Shape the future of commercial construction by driving preconstruction excellence, managing budgets, schedules, and subcontractor relationships while ensuring client satisfaction and project alignment...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$112K - $236K *

Drive strategic decision-making by evaluating investment alternatives and lifecycle opportunities. Collaborate with cross-functional teams to optimize portfolio value and support program planning thro...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead the charge in AI-driven product innovation, enhancing workflows and productivity while establishing governance for safe, scalable solutions. Collaborate across teams to unlock revenue opportuniti...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Empower teams by translating complex data into actionable insights, guiding strategic financial modeling, and enhancing decision-making processes for portfolio companies through collaborative relation...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $200K *

Join a team that's redefining architectural excellence by leading global projects, driving business growth, and fostering client relationships while overseeing studio operations and strategic initiati...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $95K *

Drive design excellence by leading a talented team, overseeing operations, and ensuring compliance with industry standards while fostering professional growth and collaboration across multiple locatio...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$280K - $300K *

Pioneer innovative AI solutions in workforce management, leading product development from concept to deployment. Collaborate with engineers and executives to create impactful agentic products that enh...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Champion a robust security program, leading a team to achieve SOC 2 Type 2 attestation while ensuring secure engineering practices across diverse products and cloud environments. Drive compliance, ris...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Transform your career by leading enterprise applications and data strategies. Drive innovation, optimize processes, and ensure security across Oracle Fusion Cloud systems while collaborating with cros...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $295K *

Lead the charge in optimizing global delivery operations, ensuring seamless hub economics and resource allocation. Collaborate with finance and commercial teams to drive data-driven decisions and main...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Media

$132K *

Lead the charge in bridging IT and program operations across the Americas, ensuring service delivery aligns with business needs. Build trust with leadership, manage escalations, and enhance communicat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Accelerate client success by owning the onboarding and rollout for enterprise clients, ensuring smooth transitions from purchase to sustained usage. Collaborate with cross-functional teams to drive ad...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$160K - $200K *

Lead the charge in transforming trust administration through strategic oversight, ensuring compliance and operational excellence while enhancing client experiences and fostering cross-functional colla...

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K - $250K *

Shape the future of risk management by leading compliance and quality initiatives. Drive effective implementation of technology solutions while providing operational leadership across key programs and...

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Transform organizational change by leading client engagements, developing tailored OCM plans, and ensuring user adoption with minimal disruption. Collaborate with stakeholders to drive successful chan...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$130K - $155K *

Elevate data product experiences by defining metrics that drive value for Mural. Collaborate across teams to shape insights, enhance reporting, and ensure data integrity, empowering organizations to m...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's dedicated to enhancing client experiences through exceptional facility management. Oversee multiple locations, collaborate on strategic initiatives, and ensure a welcoming atmospher...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $180K *

Transform the agent experience by leading strategy across recruitment, onboarding, and ongoing support. Drive engagement and success through cohesive learning and development initiatives, ensuring age...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$227K - $280K *

Lead strategic finance initiatives to empower product decisions, driving financial evaluations and business cases for new product lines. Collaborate with C-suite and product teams to optimize resource...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.