Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Unlock potential by leading complex technology projects and programs, ensuring successful delivery through disciplined management practices, AI-enabled methods, and strong client relationships. Drive...

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Shape the future of technology delivery by leading complex projects and programs. Collaborate with cross-functional teams to drive client outcomes, leveraging AI-enabled methods and fostering strategi...

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$86K - $138K *

Unlock innovative healthcare solutions by leading product strategy and lifecycle management for clinical programs. Collaborate across teams to enhance member experiences and drive business value while...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$99K - $232K *

Transform your career by leading Oracle implementation projects, managing teams, and ensuring quality delivery. Oversee complex workstreams, coach junior staff, and drive client-focused solutions in a...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Inspire and elevate design excellence as you lead a talented team, setting and maintaining visual standards, driving innovative campaigns, and partnering cross-functionally to advance Dandy's brand an...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $220K *

Lead the charge in driving growth across insurance platforms by building strategic alliances, developing executive relationships, and executing market strategies to enhance revenue and expand opportun...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Lead the design and governance of compensation strategies, ensuring market competitiveness and compliance. Oversee a team to deliver innovative solutions that align with business objectives and enhanc...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $150K *

Partner with us to build a scalable sales operations framework across the Americas, enhancing forecast accuracy and pipeline management while fostering strong relationships with field leadership and d...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$125K - $150K *

Transform business operations by leading systems and technology initiatives that enhance efficiency, drive AI enablement, and streamline processes across the organization, ensuring a robust foundation...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Advance your career by leading complex, multi-workstream programs that drive customer transformation and deliver meaningful business value through effective project management and collaboration with d...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$125K - $159K *

Innovate connections between business units and IT, translating goals into actionable tech roadmaps. Manage projects from ideation to execution by fostering collaboration and driving accountability ac...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Manage complex modular construction projects from award to delivery, integrating design, VDC/BIM, and financial performance. Lead teams and engage clients to ensure cohesive execution and successful p...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $150K *

Join a team that's defining strategies to win new business and drive growth. Lead capture development, engage stakeholders, and create compelling proposals to enhance competitive positioning and secur...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Business Services

$90K - $130K *

Drive exceptional client experiences by leading client services strategy and operations across screening services. Empower teams to deliver timely, accurate support while fostering a culture of accoun...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the charge in optimizing our national Revenue Cycle Management sales team, driving performance and market expansion. Collaborate cross-functionally to enhance client relationships and ensure cons...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$174K - $215K *

Architect the future of vulnerability intelligence by owning product strategy, roadmap, and AI integration. Collaborate with engineering and analysts to deliver impactful solutions that enhance custom...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Shape the future of scientific communications by leading global publication strategies in nephrology and hematology. Collaborate with cross-functional teams to ensure timely, high-quality deliverables...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $172K *

Shape global procurement governance and compliance by leading analytics, training, and process excellence initiatives. Drive transformation and data management in a collaborative environment to enhanc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$145K - $170K *

Drive transformative Oracle Cloud P2P solutions for Higher Education, guiding teams and clients through strategic implementations while fostering a collaborative culture and mentoring junior staff to...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$164K - $225K *

Champion enterprise transformation by leading cross-functional initiatives, ensuring governance and execution quality across value-streams. Collaborate with leaders to drive measurable outcomes and bu...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Champion a transformative revenue enablement initiative, leveraging AI to enhance sales effectiveness and streamline coaching. Lead a team to integrate innovative tools and data-driven insights across...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$96K - $133K *

Join a team that's dedicated to delivering high-quality projects on time and within budget. As a key player, you'll coordinate efforts across departments, ensuring effective communication and resource...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Lead the charge in project management by directing construction efforts, ensuring client satisfaction, and overseeing project profitability while coordinating with various stakeholders to achieve stra...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Transform project execution by developing and maintaining comprehensive CPM schedules, integrating multiple stakeholders, and ensuring timely updates to drive successful outcomes in large-scale indust...

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$123K - $164K *

Shape the future of facility management by leading a $59M portfolio across North America and LATAM. Collaborate with cross-functional teams to ensure compliance, optimize budgets, and enhance service...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.