Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$126K - $188K *

Accelerate progress at the forefront of operational risk enablement, leading regional teams to implement enterprise standards, build capabilities, and foster relationships across diverse stakeholders...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$138K - $150K *

Pioneer strategic growth initiatives by managing corporate portfolio and M&A projects. Collaborate with cross-functional teams to analyze markets, evaluate targets, and drive business development in h...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Analyze markets and drive strategic growth initiatives through M&A and business development. Collaborate with cross-functional teams to evaluate opportunities and manage corporate projects, ensuring a...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Analyze and manage corporate portfolio growth through strategic projects and business development. Collaborate with cross-functional teams to drive M&A initiatives and evaluate market opportunities, e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a team that's optimizing warehouse and logistics processes to enhance service quality and compliance. Lead D365 implementation, drive metrics development, and ensure operational excellence across...

3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$135K - $160K *

Lead the evolution of our GTM Systems Architecture, enhancing Salesforce and its tech stack for AI-native workflows. Collaborate with cross-functional teams to build a trusted data foundation and driv...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$185K - $256K *

Elevate the market growth strategy for biologics research, driving software adoption and AI use cases. Collaborate with global teams and engage with industry leaders to shape the future of molecular t...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$163K - $224K *

Join a team that's redefining People Operations by leading global service delivery, enhancing employee experiences, and driving operational excellence across Talent Acquisition and People processes fo...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $125K *

Lead technology operations for global teams, optimizing systems and support. Collaborate on strategic AI solutions, ensuring compliance and enhancing workflows. Drive efficiency and innovation in a dy...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Drive impactful communications strategies that enhance brand messaging and support business goals. Collaborate with experts to create compelling content across various channels while managing complex...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Elevate your career by leading Infor M3 ERP implementations. Drive project success through strategic planning, client management, and cross-functional collaboration while ensuring timely delivery and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Seeking a strategic leader to drive manufacturing engineering excellence across North America, integrating advanced technologies and lean principles to optimize production systems, enhance performance...

3 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Transform customer data integration strategies by leveraging your expertise to guide clients in optimizing data flow into the Fusion platform, ensuring reliability and value across complex environment...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $166K *

Lead the clinical data management process, ensuring quality and compliance from study startup to database lock. Collaborate with teams to develop databases, oversee data integrity, and train personnel...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Transform complex customer implementations into seamless successes by owning the delivery lifecycle, driving technical discussions, and ensuring stakeholder satisfaction from kickoff to go-live. Your...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$61K - $102K *

Transform customer relationships by managing a high-volume portfolio, driving renewals, upsell, and cross-sell opportunities while ensuring exceptional engagement and retention across North America...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$160K - $180K *

Elevate customer success by managing strategic federal programs, ensuring seamless implementation and adoption of innovative solutions. Collaborate with stakeholders to drive project execution and enh...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$149K - $224K *

Drive analytics excellence by leading a team to deliver impactful insights, enhance reporting capabilities, and support strategic decision-making across diverse business functions. Foster collaboratio...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$202K - $289K *

Champion growth in environmental services by leading business development, managing complex projects, and fostering client relationships in the power industry. Leverage your expertise to navigate regu...

United StatesRemote

2 weeks ago

  •   15+ years exp.  •   Technical Services

$209K - $349K *

Drive engineering excellence by leading modernization and integration efforts across technology platforms, ensuring seamless client transitions and operational stability while aligning with strategic...

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$79K - $94K *

Optimize training and workflow processes by leading program development, mentoring trainers, and collaborating with stakeholders to enhance provider experiences and operational efficiency across Care...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$185K - $344K *

Champion the evolution of field intelligence capabilities, driving strategic governance and analytics integration to enhance decision-making and execution support across the organization, ensuring ali...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$133K - $183K *

Join a team that's redefining People Operations by leading global strategies and scalable programs. Drive employee lifecycle enhancements, optimize service delivery, and foster a high-performing cultu...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $140K *

Champion product strategy and innovation, driving enhancements through AI and user insights. Collaborate with teams to deliver measurable outcomes and improve workflows in high-stakes assessment envir...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$168K - $231K *

Analyze financial data and trends to guide strategic decisions, manage budgets, and lead a team in enhancing performance. Collaborate with executives to develop long-term plans and improve organizatio...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.