Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$115K - $140K *

Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$166K - $200K *

Drive growth by leading the industrial market sector, leveraging client relationships and market insights to enhance profitability and pipeline health across environmental services. Collaborate with t...

3 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$135K - $160K *

Transform your career by leading the development of foundational components for enterprise compliance solutions. Collaborate across teams to enhance organizational unit management, ensuring scalable...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Shape the future of AI-driven product initiatives that enhance customer innovation and drive revenue growth. Collaborate across teams to translate insights into actionable product strategies and deliv...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Transform client engagement by driving growth in untapped markets, shaping impactful solutions, and delivering measurable results. Collaborate with diverse teams to connect client needs with innovativ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$150K - $180K *

Transform the future of engineering and EHS by leading strategic initiatives, optimizing capital projects, and fostering a culture of safety and compliance across a global manufacturing network...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$109K - $164K *

Transform finance operations by leading back-office processes, enhancing accuracy and compliance, and driving system improvements. Collaborate across teams to optimize financial performance and suppor...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $170K *

Pioneer innovative solutions in P&C insurance by owning the product roadmap for policy administration and commercial underwriting, integrating AI capabilities to enhance decision-making and streamline...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Shape the future of complex industrial projects by leading multidisciplinary design coordination and driving excellence in collaboration between clients, management, and engineering teams for successf...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $120K *

Accelerate sales growth by managing hardware and service functions across a designated territory. Drive project management and customer relationships to meet revenue and profitability goals while ensu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Join a team that's redefining the buyer experience in B2B software. As a Principal Product Manager, you'll lead strategy, drive product delivery, and enhance buyer trust across multiple platforms, ens...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$209K - $349K *

Pioneer the engineering strategy for a transformative platform integration, leading modernization efforts and client transitions while ensuring seamless operations across technology and business teams...

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$80K - $95K *

Transform healthcare delivery by analyzing and enhancing program efficacy for suicide prevention initiatives. Collaborate across teams to ensure Veterans receive critical benefits while navigating a d...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Lead the charge in building long-term customer relationships while optimizing operations. As a Business Manager, you'll drive strategic growth, manage key accounts, and collaborate across teams to enh...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$206K - $343K *

Lead the charge in transforming healthcare operations by delivering innovative performance solutions. Drive profitable growth through strategic program management and client engagement, ensuring measu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$108K - $180K *

Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Champion partner success by leading a dedicated team to enhance customer relationships, drive program delivery, and ensure operational excellence across educational assessments, fostering a culture of...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $125K *

Lead the development and submission of federal proposals, managing teams and resources to deliver compliant, compelling responses. Collaborate with cross-functional teams to ensure alignment with cust...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$108K - $130K *

Transform your career by leading IT development teams, driving product innovation, and ensuring alignment with business goals. Oversee technology initiatives, manage product backlogs, and enhance oper...

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Champion the delivery of innovative data solutions, leading cross-functional teams to modernize platforms and drive AI integration. Ensure project success through effective management of scope, qualit...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$169K - $298K *

Join a team that's driving growth by identifying key opportunities and leading cross-functional initiatives across Marketing, Product, Sales, and Engineering, ensuring teams execute with clarity to ma...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Transform project delivery by leading complex, multi-phase initiatives, ensuring timely completion within budget and quality standards. Collaborate with cross-functional teams and maintain accountabil...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$88K - $105K *

Join our team to oversee project management, ensuring quality, budget adherence, and timely delivery. You'll lead subcontractors, manage estimates, and maintain client relationships while driving proj...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$135K - $210K *

Lead the charge in solving complex carrier connectivity challenges in commercial insurance. Collaborate with cross-functional teams to streamline workflows and enhance product delivery, ensuring seaml...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$142K - $237K *

Lead transformative initiatives in a strategic role, driving international business growth and operational excellence across regions and functions. Collaborate with senior stakeholders to implement a...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.