Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$125K - $190K *
Accelerate progress at a leading Customer Success team, driving renewal outcomes and enhancing team effectiveness through innovative engagement strategies and AI-driven solutions for a diverse portfol...
2 weeks ago
Corporate Finance Manager, Fundraising and Investor Relations
$133K - $166K *
Champion the fundraising efforts of a dynamic corporate finance team, managing complex debt and equity processes while collaborating with senior leadership to craft compelling narratives for investors...
3 weeks ago
Director, Technology Alliances
$190K - $275K *
Join a team that's driving strategic technology alliances to transform integrations into robust commercial partnerships, focusing on co-selling, joint marketing, and stakeholder alignment while leadin...
Reposted 4 weeks ago
$110K - $166K *
Lead the charge in managing site contract negotiations and agreements, ensuring alignment with clinical study timelines. Collaborate with cross-functional teams to enhance contract processes and mento...
Reposted 1 week ago
Director, Cost of Care Solutions
$129K - $162K *
Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...
Reposted 2 weeks ago
$170K - $190K *
Elevate business systems by leading NetSuite management and integrations. Collaborate with cross-functional teams to ensure scalable, reliable processes while leveraging AI for development. Mentor a t...
3 weeks ago
$100K - $115K *
Advance the payroll function for a diverse workforce, ensuring compliance and accuracy across multiple states. This hands-on role requires expertise in payroll systems and regulations, driving process...
2 weeks ago
$100K - $120K *
Shape the future of branch operations by leading a dynamic team, driving financial success, and fostering strong customer relationships while ensuring safety and quality in project execution...
2 weeks ago
Director, Shared Services - Order to Cash
$120K - $145K *
Elevate the Order-to-Cash operations by leading a high-volume team, ensuring billing accuracy and cash application efficiency. Drive automation and continuous improvement while collaborating cross-fun...
Yesterday
$110K - $125K *
Elevate product strategy and delivery by leading a multidisciplinary team to ensure alignment with stakeholder needs and mission-critical outcomes in a fully remote environment...
2 weeks ago
Travel Project Manager - Mission Critical
$88K - $105K *
Drive project success by managing construction initiatives, ensuring quality, safety, and profitability while meeting client expectations. Collaborate with teams to deliver predictable outcomes and up...
Today
Sr. Director of Web and Digital Strategy
$135K - $160K *
Lead the charge in shaping and executing enterprise digital strategy, overseeing web platforms and social media while aligning business goals with audience needs to enhance brand presence and performa...
4 weeks ago
$99K - $232K *
Transform the future of custom application development by leading teams in designing, building, and testing innovative solutions across cloud-native and on-premise environments, while mentoring junior...
Today
Vice President of Product Management
$235K - $265K *
Champion product innovation by leading a dynamic team to define strategy, drive decisions, and ensure successful launches that align with company growth and customer needs in the health technology sec...
4 weeks ago
Test Manager, Professional Services
$132K - $198K *
Elevate quality assurance practices by leading test strategy and execution for customer implementations. Collaborate with teams to enhance product quality, mitigate risks, and establish scalable testi...
Reposted 1 week ago
Human Resources Project Manager
$100K - $120K *
Transform the employee experience by leading impactful HR initiatives, managing events, and enhancing organizational culture. Collaborate across teams to drive engagement, support leadership developme...
3 weeks ago
Manager, Strategic Client Solutions
$100K - $120K *
Accelerate client relationships by managing strategic accounts, driving revenue growth, and expanding service lines. Collaborate with internal teams to ensure client satisfaction and deliver tailored...
1 week ago
$95K - $115K *
Join a team that's leading multi-functional efforts in major defense acquisition programs. Drive program performance assessments and provide expert technical guidance while collaborating with key stak...
Yesterday
Associate Director, Integrated Planning & Strategy
$96K - $120K *
Join a team that's redefining brand engagement by architecting full-funnel ecosystems. Lead strategic initiatives across diverse channels, driving growth through innovative connections and insights wh...
Yesterday
12 - Director, Business Development 1
$140K - $195K *
Engage in strategic business development, overseeing global projects and teams. Drive long-term planning, policy formation, and customer negotiations while fostering collaboration with senior manageme...
Reposted today
$115K - $135K *
Optimize product delivery in fintech by leading cross-functional teams, translating strategic vision into actionable requirements, and ensuring high-quality outcomes. Drive technical engagement and ma...
Yesterday
$113K - $125K *
Drive product strategy and outcomes in a senior role, focusing on educational equity and data-driven impact. Collaborate with cross-functional teams to shape product direction, prioritize initiatives...
1 week ago
Operations Manager, Global Strategic Accounts
$130K - $160K *
Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...
3 weeks ago
Senior Manager, Programs - Global Expansion and New Initiatives
$173K - $255K *
Empower global expansion by leading customer operations strategy, managing complex programs, and driving continuous improvement across international markets. Collaborate with cross-functional teams to...
4 weeks ago
Senior Account Manager, Promotional Medical Education
$85K - $95K *
Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.