Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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650

Director, Program Management Jobs in North Carolina

Sort By: Relevance

$148K - $195K *

Empower global clinical trial delivery through robust stakeholder management, overseeing complex studies from design to report. Foster collaboration, ensure compliance, and optimize operations for suc...

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$200K - $250K *

Champion product security initiatives by leading a skilled team, architecting compliance frameworks, and managing incident response to enhance trust across all products and stakeholders...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $321K *

Lead complex, large-scale private cloud programs, ensuring seamless integration across multiple technologies and teams. Drive alignment, manage risks, and deliver innovative solutions while engaging w...

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform dealer operations by leading product strategy for Layered Apps, enhancing service planning and technician productivity through AI-driven solutions. Collaborate across teams to deliver impact...

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$128K - $178K *

Lead the charge in shaping the future of destination marketing through data-driven insights and innovative product strategies. Collaborate with cross-functional teams to enhance customer experiences a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$169K - $313K *

Oversee and execute strategic technology initiatives, ensuring effective program delivery and stakeholder collaboration to drive impactful business solutions and organizational change...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Technical Services

$175K - $210K *

Transform the Platform organization by owning roadmap planning, development processes, and cross-functional coordination. Drive execution and ensure alignment with business goals while providing leade...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$145K - $190K *

Lead the charge in designing and optimizing scalable data pipelines using Azure, PySpark, and Airflow. Collaborate with teams to ensure data quality and performance while mentoring engineers and drivi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Execute comprehensive program management for a critical Air Force contract, leading a diverse team to ensure compliance, quality, and performance across multiple global operations while maintaining 24...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$95K - $115K *

Elevate project delivery by leading cross-functional teams in Interactive Response Technology, ensuring client satisfaction and timely execution while managing risks and fostering continuous improveme...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$216K - $236K *

Join a team that's redefining AI product management by driving ROI through innovative solutions. Lead the development of AI capabilities that enhance Alteryx workflows, ensuring faster, better, and ch...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$160K - $200K *

Transform the Software Business Model by leading strategic initiatives, optimizing processes, and fostering innovation. Collaborate across teams to enhance customer experiences and drive operational e...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$195K - $230K *

Drive growth by leading go-to-market strategies for TMC partnerships, building and executing plans from the ground up. Collaborate cross-functionally to influence product development and represent the...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$180K - $220K *

Empower a dynamic team of software engineers to innovate and deliver impactful tech solutions, collaborating with cross-functional partners to enhance pediatric healthcare for children with special ne...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$150K - $180K *

Join a dynamic team to drive operational excellence across Business Units, ensuring accurate forecasting, insightful reporting, and effective execution. Collaborate closely with GMs to enhance perform...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $240K *

Drive cross-domain visibility and coordination in a dynamic engineering environment. As the sole TPM, you'll ensure programs are on track, dependencies are mapped, and automation enhances efficiency a...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Shape the future of healthcare by leading complex implementations across provider and payor organizations. Drive project success through collaboration, strategic planning, and innovative solutions whi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$152K - $209K *

Explore innovative technology solutions as you define and govern enterprise architecture for Commercial & Medical domains, ensuring alignment with business strategy and regulatory compliance while dri...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$113K - $189K *

Drive enterprise-scale delivery by leading Agile initiatives and managing programs. Collaborate with cross-functional teams to align roadmaps, ensure operational excellence, and provide executive-leve...

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$147K - $220K *

Drive the success of clinical study projects by managing timelines, budgets, and quality standards. Collaborate with teams and clients to ensure project objectives are met while fostering a culture of...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$147K - $220K *

Optimize project delivery by leading clinical study initiatives, ensuring quality, budget, and timelines are met. Collaborate with teams and clients to drive success in complex global trials while man...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $215K *

Shape the future of value-based payments by leading product strategy, overseeing team development, and driving market innovations within a collaborative, cross-functional environment...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$500K+*

Lead the transformation of media ingestion and distribution systems, driving automated, AI-powered workflows that enhance efficiency and accelerate content delivery to a global audience. Collaborate a...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$170K - $200K *

Lead the charge in managing complex Life Sciences programs, ensuring alignment with customer commitments. Drive delivery across teams, proactively addressing risks and building a PMO as the business s...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Transform your career by driving new business growth in enterprise accounts. Leverage your expertise in IT sales to identify key opportunities, build trusted relationships, and deliver strategic solut...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.