Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Director, Program Management Jobs in North Carolina

Sort By: Relevance

$108K - $130K *

Accelerate project execution by leading medium-sized initiatives, ensuring compliance with standards, and guiding cross-functional teams to deliver optimal results while prioritizing strategic alignme...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$131K - $219K *

Grow your career with us as a Principal Engineer, leading Configuration Management processes and driving innovation across Gas Power products. Collaborate with cross-functional teams to enhance produc...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$199K - $258K *

Drive your career forward by leading the CMC development of small molecule drug products. Collaborate cross-functionally to ensure successful formulation, process development, and regulatory submissio...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$206K - $261K *

Accelerate the commercialization of AI-driven solutions by leading strategy and planning efforts. Collaborate cross-functionally to define go-to-market frameworks, enhance retailer experiences, and dr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$200K - $240K *

Engage in strategic initiatives that drive growth and operational excellence. Collaborate with senior leadership to shape enterprise strategy and lead cross-functional programs, ensuring impactful out...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$171K - $338K *

Join a team that's transforming HR and IT service delivery through AI. As a Senior Manager, you'll lead engagements, shape strategies, and advise clients on innovative solutions, driving growth and en...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$171K - $338K *

Lead the charge in transforming HR and IT service delivery through AI. As a Senior Manager, you'll oversee multiple engagements, build client relationships, and drive practice growth while mentoring t...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Innovate product management by leading the evolution of legacy and cloud solutions. Drive customer adoption, improve outcomes, and enhance user experience while collaborating with cross-functional tea...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $158K *

Champion safety excellence by leading enterprise-wide initiatives, enhancing training, and ensuring compliance. Collaborate across departments to drive impactful safety programs and data-driven soluti...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$135K - $160K *

Champion the delivery of large-scale technical programs by leading cross-functional teams, enhancing communication and operational efficiency, and driving strategic decisions to empower users and tack...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's dedicated to delivering high-quality construction projects. Oversee project management, lead teams, and strengthen client relationships while ensuring projects are completed on time...

6 days ago

  •   8 - 10 years exp.  •   Technical Services

$135K - $160K *

Drive customer success and system reliability by leading a high-impact, agile engineering team focused on short-term initiatives that enhance product adoption and solve complex integration challenges...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$235K - $265K *

Champion product innovation by leading a dynamic team to define strategy, drive decisions, and ensure successful launches that align with company growth and customer needs in the health technology sec...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$113K - $165K *

Empower cross-functional teams by leading complex product development projects, ensuring alignment with business goals while driving continuous improvement and optimizing productivity throughout the p...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $200K *

Shape the future of international financial reporting by leading statutory and sustainability reporting for global entities, ensuring compliance and accuracy while collaborating with cross-functional...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in managing complex public safety projects, ensuring timely delivery and high customer satisfaction. Oversee a diverse portfolio while collaborating with cross-functional teams to driv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $246K *

Lead the charge in delivering innovative CSP offerings by managing cross-functional teams, ensuring project execution within budget and timelines, and driving solutions in a dynamic environment. Stron...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$160K - $246K *

Lead cross-functional teams to deliver innovative CSP offerings, focusing on compute, storage, and GPU products. Utilize senior project management skills to ensure timely and budget-compliant executio...

Morrisville, NCRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$180K - $230K *

Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Transform our growth marketing strategy by driving demand generation and managing a high-performing team. Collaborate with cross-functional leaders to optimize pipeline performance and leverage automa...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Shape the future of cybersecurity by leading strategic initiatives and managing complex programs across IT, OT, and IoT. Drive collaboration with diverse stakeholders to enhance security postures and...

Reposted 5 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$124K - $156K *

Shape the future of AI Services by owning product strategy and execution. Collaborate with engineering teams to define agentic capabilities, drive tool strategies, and establish AI quality standards t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Elevate digital experiences by guiding site operations and enhancing user engagement. Collaborate with cross-functional teams to implement innovative features and optimize performance metrics, driving...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $180K *

Drive operational excellence by managing the leadership team's cadence, metrics, and contract operations. This hands-on role blends business judgment with execution, ensuring alignment and efficiency...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Champion a team of product managers to drive innovative software solutions. Shape product direction, enhance customer understanding, and elevate product quality while fostering leadership and collabor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.