Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Director, Program Management Jobs in North Carolina

Sort By: Relevance

$180K - $200K *

Accelerate progress at regional Professional Services by leading teams, driving growth and quality in consulting engagements while fostering strategic partnerships and developing innovative service of...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate global post-market surveillance by leading a team focused on safety, compliance, and performance of medical devices. Drive field actions, analyze data, and collaborate cross-functionally to en...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$164K - $314K *

Unlock your potential by leading strategic data initiatives that drive business success. Collaborate with cross-functional teams to enhance analytics capabilities and deliver actionable insights, shap...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$188K - $313K *

Lead the charge in advancing quantitative systems pharmacology through innovative modeling and simulation strategies, driving integration across drug discovery and development to enhance patient outco...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$171K - $245K *

Champion the strategic product lifecycle for healthcare solutions, driving innovation and collaboration across teams to enhance patient access and streamline workflows. Deliver measurable outcomes tha...

Yesterday

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$93K - $159K *

Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$91K - $145K *

Shape the future of data solutions by leading complex pharmacy claims and physician-level data integrations. Collaborate with cross-functional teams to deliver high-quality, scalable solutions that me...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $168K *

Drive impactful medical congress operations by leading planning, execution, and cross-functional collaboration. Own vendor relationships and budgets while ensuring compliance and delivering high-quali...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $213K *

Champion the development of a key platform, driving strategy, success metrics, and technical depth while collaborating across teams to deliver impactful solutions that meet customer needs and enhance...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$99K - $199K *

Join a dynamic team to lead project controls in life sciences, enhancing project delivery through data-driven insights and collaboration. Drive excellence in cost, schedule, and performance management...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$99K - $199K *

Join a team that's dedicated to enhancing patient lives by leading project controls for biomanufacturing. Collaborate with cross-functional teams to deliver high-quality life sciences projects while m...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Drive the development of innovative security systems using AI/ML, managing risk across identity and access management. Collaborate with cross-functional teams to enhance security while maintaining ope...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team to lead proposal and security response efforts, driving innovation and quality. Manage a skilled group, streamline processes, and enhance collaboration across functions to achieve...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$173K - $290K *

Lead product strategy for design systems and accessibility, driving innovation and adoption across teams. Shape integrated roadmaps, enhance product health, and ensure alignment with evolving AI-nativ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Champion strategic sourcing initiatives across diverse categories, leading a high-performing team to drive measurable value. Foster partnerships, negotiate with suppliers, and implement innovative sol...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $140K *

Drive product innovation by leading the development of AI-enabled solutions for public sector agencies, enhancing early childhood systems through strategic vision, technical architecture, and customer...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Drive your career forward as a Senior Project Manager overseeing multi-million dollar projects. Collaborate with cross-functional teams to ensure project success, maintain quality standards, and foste...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$130K - $155K *

Elevate data product experiences by defining metrics that drive value for Mural. Collaborate across teams to shape insights, enhance reporting, and ensure data integrity, empowering organizations to m...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$183K - $215K *

Shape the future of North American inland transportation by leading product strategy and development. Collaborate with cross-functional teams to deliver actionable insights and drive market success in...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $220K *

Shape the future of data-driven solutions by leading our Data, AI & Cloud practice. Drive strategic growth, manage P&L, and inspire cross-functional teams to deliver innovative consulting solutions gl...

1 month ago

  •   8 - 10 years exp.  •   Information Technology

$228K - $342K *

Advance the future of R&D governance and portfolio management by leading strategic decision-making processes, optimizing operational efficiency, and ensuring seamless progression of therapeutic assets...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$227K - $280K *

Lead strategic finance initiatives to empower product decisions, driving financial evaluations and business cases for new product lines. Collaborate with C-suite and product teams to optimize resource...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$130K - $165K *

Lead the charge in managing cost controls for complex construction projects, ensuring accurate financial insights and risk identification. Collaborate with diverse teams to support informed decision-m...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$154K - $196K *

Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$109K - $183K *

Join a team that's driving innovation in product operations. You'll manage program initiatives, streamline processes, and enhance portfolio reporting while collaborating with cross-functional teams to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.