Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Director, 211 Manufacturing Quality and Regulatory Affairs
$190K - $228K *
Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...
Reposted 2 weeks ago
Director, SAP Technology Lead - Merchandising
$160K - $240K *
Lead the transformation of SAP merchandising solutions, ensuring seamless integration across finance, supply chain, and digital platforms. Drive scalable, high-performing solutions that enhance operat...
Yesterday
$140K - $175K *
Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...
2 weeks ago
$162K - $238K *
Design and optimize R&D operations to enhance organizational effectiveness through data-driven insights, collaboration, and governance. Partner cross-functionally to drive continuous improvement and e...
4 weeks ago
Project Manager - Life Sciences Construction
$110K - $130K *
Shape project success by leading complex initiatives from conception to completion. Ensure projects are safely executed on time and within budget while fostering client relationships and enhancing ope...
Reposted 2 weeks ago
Executive Director of Client Delivery
$150K - $180K *
Partner with us to lead complex software implementations, ensuring client success through hands-on technical guidance, effective communication, and cross-functional coordination. Drive delivery excell...
1 week ago
$140K - $185K *
Transform project delivery by managing IT initiatives for California agencies. Collaborate with state staff to ensure timely, budget-compliant outcomes while leveraging Agile methodologies and large s...
1 week ago
Senior Strategic Program Manager, Data Center and AI
$132K - $165K *
Accelerate progress at multi-site data center and AI programs valued over $25M. Lead diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive c...
2 weeks ago
Manager, Service Delivery Management
$130K - $140K *
Lead the charge in operational excellence across multiple schools, enhancing leadership effectiveness and ensuring compliance. Collaborate with teams to drive enrollment growth and academic improvemen...
Today
$188K - $245K *
Empower innovation by leading a UX design team focused on clinical workflows. Collaborate across functions, drive strategic direction, and enhance AI integration while advancing design quality in heal...
4 weeks ago
$130K - $155K *
Optimize your career by leading enterprise data governance initiatives. Drive data quality, compliance, and AI readiness across divisions, transforming governance into a strategic business enabler whi...
Yesterday
Senior Director I, Umbrella Product Management
$160K - $190K *
Join a team that's redefining the Umbrella line of business by overseeing P&L, driving innovative strategies, and collaborating across departments to achieve profitable growth and enhance customer sat...
1 week ago
Product Manager, Clinical Programs & Case Management
$86K - $138K *
Unlock innovative healthcare solutions by leading product strategy and lifecycle management for clinical programs. Collaborate across teams to enhance member experiences and drive business value while...
1 week ago
Program Manager, Quality & Commissioning, NA
$120K - $130K *
Champion quality and commissioning excellence across diverse construction projects, ensuring compliance and safety while fostering collaboration among teams and stakeholders to drive impactful results...
1 week ago
Event Project Manager, Corporate Meetings & Events
$75K - $94K *
Shape exceptional client experiences by leading AV production and design projects. Collaborate across sectors to ensure successful event execution while building lasting relationships and maintaining...
Reposted today
Symphony Project Manager PMO/IT
$95K - $115K *
Champion project success by coordinating business and technology initiatives, ensuring adherence to quality and regulatory standards while managing cross-functional teams to deliver on time and within...
2 weeks ago
$150K - $190K *
Unlock potential by managing complex technical programs that drive innovation and operational excellence. Collaborate with cross-functional teams and clients to ensure successful delivery of large-sca...
2 weeks ago
$110K - $130K *
Lead the charge in managing a large-scale FHWA communications program, ensuring effective contract leadership, quality management, and stakeholder engagement across a multidisciplinary team to deliver...
3 weeks ago
$110K - $130K *
Elevate product execution by translating client needs into actionable requirements, collaborating with engineering and data science teams to deliver standardized measurement solutions across various c...
4 days ago
Executive Director, System Software Development
$160K - $200K *
Transform engineering productivity by leading global systems software development, ensuring quality and efficiency across Linux, SKY, and Android platforms. Drive innovation through automation, AI, an...
3 weeks ago
Director of Product , Data Flywheel
$200K - $245K *
Pioneer data-driven engineering for our Autonomy Data Flywheel initiative, overseeing the entire lifecycle to enhance AI-driven operations. Collaborate with cross-functional teams to achieve quality a...
Reposted 3 weeks ago
Director, Marketing Process & Technology
$200K - $352K *
Shape the future of marketing compliance by leading automation initiatives, overseeing review processes, and driving collaboration across teams. This hands-on role combines strategic oversight with di...
3 weeks ago
Director, Product Management - Infrastructure Automation
$200K - $220K *
Lead product management for an innovative infrastructure automation platform, driving strategy and vision while managing a team of senior product managers. Collaborate cross-functionally to enhance cu...
Yesterday
Executive Director, Clinical Supply Consulting & Intelligence
$250K - $350K *
Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...
2 weeks ago
Director, SAP Technology Lead - Finance
$160K - $240K *
Lead the SAP Finance transformation strategy, architecting solutions for a multi-billion-dollar retail organization. Drive enterprise finance capabilities, ensuring alignment with business goals and d...
Yesterday
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.