Are you looking for high-paying Director of Information Systems jobs? You've come to the right place. We host a wide range of jobs in this category that pay $100K or more.
Directors of Information Systems oversee an organization's IT strategy and ensure that systems, infrastructures, and networks operate smoothly.
Typical qualifications include a bachelor's or master's degree in IT or related fields and several years of experience.
$68K - $105K *
Join a team that oversees complex programs, managing cross-functional projects and resources to deliver impactful solutions, while ensuring alignment with business objectives, quality, and budget cons...
4 days ago
Standards Development Organization Liaison / Knowledge Management
$100K - $120K *
Lead the charge in health data standards development by engaging with key organizations, analyzing standards impact, and managing knowledge resources to enhance VHA systems and facilitate interoperabi...
2 weeks ago
Director of Project and Program Management
$160K - $200K *
Optimize your leadership skills by managing a team that drives technology project delivery. Oversee the PMO, streamline processes, enhance AI adoption, and ensure ROI metrics are met, while fostering...
3 days ago
$120K - $160K *
Unlock potential by designing advanced data architectures that enable agentic systems. Collaborate across teams to enhance data flow, governance, and retrieval methods in a dynamic environment focused...
Reposted 1 week ago
Manager, Automation OT Delivery
$110K - $130K *
Advance operational technology systems for data center infrastructure, ensuring reliability, security, and scalability while collaborating cross-functionally to optimize processes and compliance withi...
3 weeks ago
$111K - $150K *
Shape the future of asset management by leading best practices, ensuring accountability, and conducting audits while managing property control processes to support contract requirements and efficiency...
6 days ago
Chief of Staff: AI & Data Transformation & Analytics
$150K - $180K *
Drive strategic initiatives as Chief of Staff, enabling the AI & DT&A Practice Leader to excel while ensuring operational consistency and organizational clarity in a fast-paced, innovation-focused env...
Reposted 1 week ago
System Director Hospital Medicine Operations
$150K - $180K *
Unlock your potential as a strategic leader driving clinical excellence and operational efficiency in hospital medicine programs. Collaborate with cross-functional teams to enhance patient outcomes an...
1 week ago
Director, Advancement Operations & Volunteer
$90K - $110K *
Lead the strategic direction for development operations and volunteer engagement, overseeing impactful fundraising events, optimizing budgets, and enhancing volunteer experiences to drive community co...
3 weeks ago
$150K - $180K *
Champion enterprise sales by driving, managing, and closing new client relationships within the financial services industry, leveraging strong sales skills and industry knowledge to expand business op...
2 weeks ago
$160K - $200K *
Transform healthcare sales by leading strategic initiatives across major US health systems. Drive results through consultative selling, tailored business cases, and robust consensus building with C-su...
1 week ago
Principal Revenue Operations Systems Lead
$125K - $150K *
Drive the optimization of global Deal Desk operations, enhancing efficiency and scalability. Collaborate with cross-functional teams to streamline processes, implement AI solutions, and ensure robust...
2 days ago
Project Manager III - Strategic Business Initiatives
$87K - $157K *
Manage complex projects by leading cross-functional teams, ensuring alignment with strategic objectives, maintaining documentation, and effectively communicating with stakeholders to achieve quality d...
Reposted 4 days ago
Application Sys Analyst IV - Healthy Planet, Primary Architect (Remote)
$97K - $146K *
Take ownership of the Healthy Planet application, guiding design, governance, and strategic direction. Collaborate across Epic platforms, lead initiatives, and ensure alignment with best practices to...
Reposted 1 week ago
Director, FP&A Business Partner
$135K - $160K *
Unlock your potential as you own the financial performance of a dynamic business unit, driving strategic decisions and enhancing visibility to shape impactful processes and outcomes. Join a hands-on l...
Reposted today
$120K - $145K *
Optimize AI security by assessing vulnerabilities, crafting defenses, and collaborating across teams to embed security in AI systems, ensuring safe, responsible deployment in a fast-paced healthcare e...
2 weeks ago
$150K - $180K *
Contribute to AI governance by operationalizing risk controls, managing vendor risks, and leading threat modeling for AI/ML systems. Collaborate across teams to ensure compliance and enhance security...
2 days ago
Director, Innovation & Deployment
$154K - $278K *
Pioneer innovative solutions by leading technology deployment to enhance operational value. Collaborate across teams to identify opportunities, develop working solutions, and ensure successful transit...
Today
$150K - $180K *
Unlock your potential as a key strategist, bridging Zencore's sales and Google Cloud's enterprise teams. Drive co-sell revenue, enhance brand visibility, and secure vital program access in a fast-pace...
3 weeks ago
Lead Director, Coding Audit & Compliance
$100K - $231K *
Join a team that's dedicated to enhancing coding quality and compliance through strategic leadership, oversight, and innovative solutions, ensuring adherence to regulatory standards and driving organi...
4 days ago
Director, New Business Development & Customer Finance
$125K - $150K *
Accelerate business growth by leading new financing initiatives and strategic acquisitions across a defined U.S. territory, while building lasting relationships with independent owners to create impac...
Reposted 2 weeks ago
Advanced Systems Site Engineer
$112K - $125K *
Unlock potential by managing equipment logistics and support activities across diverse environments, ensuring operational readiness through precise inventory control and effective communication with t...
3 days ago
VP, Enterprise Product Management - Enterprise Integration & Platform Modernization
$207K - $392K *
Lead the charge in defining and executing strategic enterprise integration initiatives that modernize core platforms, improve operational transparency, and drive agility across the organization, foste...
3 days ago
Director, Payor Contracting & Population Health
$94K - $148K *
Transform healthcare negotiations by leading payer strategies and optimizing population health incentives. Engage cross-functionally to craft innovative solutions and manage complex relationships nati...
1 week ago
$80K - $95K *
Join a team that's redefining marketing operations by leading project management, integrating AI, and enhancing workflows. Drive cross-functional collaboration and streamline processes to support inno...
2 days ago
What is the role of a Director, Information Systems?
A Director of Information Systems is responsible for overseeing the IT strategy of an organization, ensuring systems, infrastructures, and networks operate smoothly.
What qualifications do I need to be a Director, Information Systems?
Typical qualifications include a bachelor's or master's degree in IT or related fields and several years of experience.
What jobs are available on Ladders for Directors, Information Systems?
Ladders hosts a wide range of high-paying jobs for Directors of Information Systems. All jobs listed pay $100K or more per year.