Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director, Product Management | Applied AI
$160K - $190K *
Lead and develop a team of Product Managers to drive AI-powered product strategy, governance, and investment decisions. Shape the organization's AI capabilities while ensuring responsible AI practices...
2 weeks ago
$86K - $119K *
Lead the charge in building and supporting enterprise data solutions that transform business requirements into scalable models, enhancing analytics and reporting capabilities across the organization...
Today
$95K - $115K *
Drive the delivery and maintenance of Interactive Response Technology (IRT) systems, ensuring successful client interactions and project outcomes through effective oversight, training, and support man...
2 weeks ago
Senior Manager, Technology Internal Audit
$243K - $251K *
Join a team that's dedicated to enhancing internal audit processes through innovative risk management strategies, leveraging data analytics and technology to drive efficiency and compliance across the...
Yesterday
Senior Cloud Infrastructure Engineer
$150K - $175K *
Shape the cloud infrastructure landscape by ensuring security, scalability, and efficiency. Collaborate with engineers to build resilient systems and drive best practices, enabling smooth deployment a...
Reposted 2 weeks ago
$78K - $100K *
Lead the end-to-end program management for enterprise clients in financial services, driving alignment and execution across cross-functional teams to achieve measurable business outcomes and ensure se...
4 days ago
Strategic Account Director, Key Accounts
$150K - $180K *
Join a team that's driving enterprise growth by managing key accounts, expanding relationships, and executing strategic plans. Leverage your expertise to enhance customer value and influence major org...
2 weeks ago
Portfolio Design, Analytics, & Risk Principal
$126K - $252K *
Lead the charge in advancing risk management and investment strategies through innovative modeling, comprehensive analysis, and collaboration with top investment teams to drive informed decision-makin...
Reposted 5 days ago
$165K - $220K *
Pioneer innovative solutions by collaborating with defense clients to operationalize real-time intelligence. Design and deploy data pipelines and applications on Palantir Foundry, ensuring mission-cri...
4 weeks ago
$180K - $190K *
Unlock potential by managing and automating cloud infrastructure, ensuring system security, and optimizing CI/CD pipelines. Collaborate with teams to enhance reliability and performance in a dynamic...
3 days ago
$80K - $95K *
Lead the charge in analytical chemistry by conducting experiments and overseeing studies under GLP guidelines. Collaborate with a diverse team to deliver high-quality research while ensuring data accu...
5 days ago
$135K - $150K *
Lead the charge in enhancing cybersecurity operations by managing incident response, mentoring SOC analysts, and developing processes to effectively identify and mitigate threats in a 24/7 Security Op...
Reposted 3 days ago
Principal Researcher, Benchmarks, Evaluation, and Standards
$133K - $197K *
Drive impactful research by leading technical evaluations and benchmarks in AI. Collaborate with diverse stakeholders to ensure principled guidance that integrates social and technical considerations...
1 week ago
$120K - $145K *
Shape the future of EHS&S solutions by architecting scalable digital frameworks, collaborating with stakeholders to define requirements, and guiding technology lifecycles from design to deployment, en...
Yesterday
Enterprise Account Executive - Financial Services
$240K - $330K *
Join a team that’s pioneering growth in revenue intelligence by driving new business opportunities in financial services and healthcare. Leverage your extensive sales expertise to build relationships...
Reposted 5 days ago
$90K - $110K *
Drive transformation by collaborating with stakeholders to analyze and enhance business processes, ensuring effective technology adoption and operational improvements within a dynamic environment...
2 weeks ago
Senior Project Manager, Marketing PMO
$110K - $130K *
Lead complex, cross-functional marketing initiatives from planning to execution, driving accountability and collaboration across teams while enhancing project management processes and methodologies fo...
2 weeks ago
Research Scientist II - Deepfake Detection & Authentication (Video & Audio)
$160K - $185K *
Contribute to groundbreaking research in deepfake detection and identity authentication. Drive innovative projects, collaborate with engineers, and translate complex models into scalable solutions, en...
6 days ago
Senior Compliance Analyst-Advisory Services
$95K - $115K *
Lead the charge in enhancing compliance processes within advisory services, utilizing your expertise to develop efficient oversight procedures, conduct data quality control, and ensure adherence to re...
1 week ago
$139K - $235K *
Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...
4 days ago
Programming & Editorial Manager
$110K - $130K *
Transform your career by leading content strategy and production for dynamic digital channels. Drive audience engagement and performance through compelling storytelling, collaboration, and innovative...
3 weeks ago
Senior Strategic Finance Manager
$190K - $214K *
Drive strategic finance initiatives by leading FP&A processes, collaborating with cross-functional teams, and building financial models to evaluate product profitability and investments. Shape the fut...
2 weeks ago
Senior Site Reliability Engineer
$158K - $234K *
Develop and enhance infrastructure and tools to empower developers in delivering scalable, secure, and reliable software. Collaborate across teams to improve system reliability, automate processes, an...
3 weeks ago
$110K - $130K *
Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...
1 week ago
$120K - $130K *
Elevate your career by leading the design and implementation of complex software solutions. Collaborate with cross-functional teams to drive technical decisions and mentor engineers, ensuring scalable...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.