Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director, AWS AI Application Engineering
$155K - $410K *
Lead the design and modernization of AWS-native applications, guiding teams through architecture decisions and client relationships while driving AI-enabled engineering and strategic growth across mul...
2 weeks ago
Staff Engineer, Project Engineering
$110K - $130K *
Optimize manufacturing capabilities by managing capital projects up to $5MM. Collaborate with cross-functional teams to ensure compliance with GMP standards and drive project success through effective...
Reposted 2 days ago
Infrastructure Architecture Manager
$110K - $130K *
Join a dynamic team to design and optimize enterprise infrastructure, leading initiatives in network architecture, virtualization, and cloud services while ensuring reliability and security across sys...
5 days ago
$143K - $169K *
Drive strategic revenue forecasting and reporting for hardware, collaborating with cross-functional teams to enhance decision-making and insights. Engage with executive leadership to shape narratives...
Yesterday
Global HSE Industrial Hygiene Manager
$94K - $224K *
Shape the future of industrial hygiene by leading global programs, ensuring compliance, and fostering a culture of safety. Collaborate with stakeholders to enhance health and safety practices while dr...
1 week ago
$110K - $130K *
Elevate client outcomes by managing complex AI and data programs. Serve as the primary contact for multi-geo teams, ensuring technical delivery aligns with business goals. Foster strong relationships...
Reposted 3 weeks ago
Senior Engineering Manager - GTM
$239K - $298K *
Discover a pivotal role in shaping the future of our engineering function. Lead a small team to enhance our GTM engine, integrating product and marketing efforts while driving innovation in technology...
1 week ago
Lead Change, Release and Deployment Analyst
$102K - $190K *
Elevate change management processes by leading operational execution and quality assurance. Oversee complex change reviews, coach teams, and ensure compliance with governance standards while enhancing...
Today
Program Analyst (Earned Value Management)
$80K - $95K *
Transform project outcomes by analyzing performance data, forecasting costs, and ensuring compliance. Collaborate with contractors to identify risks and present actionable insights to leadership, driv...
5 days ago
Experienced Senior Turbine Aerodynamicist
$150K - $190K *
Unlock your potential as a Senior Turbine Aerodynamicist, leading innovative turbine design and analysis for aircraft and industrial engines. Collaborate across teams to drive strategic improvements a...
3 weeks ago
$90K - $110K *
Advance your career by delivering critical cost estimates for federal programs. Collaborate with a dynamic team to enhance national security through effective budgeting and analysis of advanced commun...
1 week ago
Software Test Engineer (Engineer III)
$95K - $115K *
Join a dynamic team to elevate software quality through innovative testing strategies, ensuring robust performance and scalability. Collaborate cross-functionally to drive testing initiatives and enha...
6 days ago
$95K - $115K *
Join a team that's enhancing employee separation processes through expert Workday configuration. Leverage your skills in Termination and Offboarding to ensure seamless transitions while collaborating...
5 days ago
$104K - $166K *
Optimize your career by ensuring the performance and scalability of critical AWS platforms. Collaborate with cross-functional teams to deliver secure, automated solutions while enhancing operational e...
6 days ago
$104K - $166K *
Elevate the performance and reliability of critical AWS cloud platforms. Collaborate with cross-functional teams to optimize infrastructure, automate processes, and ensure secure, scalable solutions t...
1 week ago
Principal Technical Program Manager, Data Centers
$102K - $209K *
Transform data center operations by leading end-to-end capacity delivery programs. Collaborate with diverse teams to ensure timely project execution, quality assurance, and stakeholder engagement, dri...
2 weeks ago
Lead Customer Insights & Data Analyst
$115K - $125K *
Lead transformative customer insights initiatives, integrating complex data to enhance marketing strategies. Shape data processes and develop analytical solutions to empower decision-making and drive...
Reposted 5 days ago
Principal Sales Solutions Consultant
$160K - $195K *
Engage with healthcare payer clients to architect integrated solutions, driving revenue growth through strategic discovery, technical leadership, and value engineering. Collaborate across teams to del...
1 week ago
Member of Engineering, Backend - AI
$250K - $250K+*
Pioneer the future of developer AI by architecting scalable backend systems that enhance real-world product experiences through developer-centric cloud infrastructure...
Reposted 3 days ago
Project Engineer (Rail Project Engineer)
$100K - $140K *
Lead the charge in designing and executing rail projects, ensuring compliance and quality. Collaborate with multidisciplinary teams and strengthen client relationships while managing project delivery...
3 weeks ago
$110K - $130K *
Elevate incident response capabilities by developing dashboards and alerts, optimizing cloud performance, and ensuring security compliance. Collaborate with product teams to enhance IAM needs while dr...
1 week ago
Senior Manager, EPC Estimation
$120K - $145K *
Oversee global EPC proposal processes for Battery Energy Storage Systems, collaborating with cross-functional teams to deliver innovative, customer-centric solutions while driving continuous improveme...
2 weeks ago
Senior Manufacturing & Automation Engineer
$100K - $120K *
Lead and develop a dynamic engineering team to enhance manufacturing processes, establish standards, and drive cross-functional collaboration, ensuring alignment with business objectives in high-preci...
3 weeks ago
Senior Engineer, Agentic Engineering Governance, Open Source
$153K - $166K *
Join a team that's shaping the future of AI governance in software development. As a Senior Engineer, you'll design policies and tools that ensure safe, effective use of AI coding agents, empowering d...
2 weeks ago
$150K - $180K *
Join a team that's redefining customer success by leveraging AI to enhance the post-sale journey. Lead and scale a dynamic team while driving retention and expansion for enterprise clients in a fast-p...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.